Complexation studies on inositol-phosphates. V. Cu2+, Zn2+, Fe2+ and Fe3+ complexes of some myo-inositol triphosphates

Inframolecular acid–base and coordination properties towards Na+and Mg2+of myo-inositol 1,3,4,5,6-pentakisphosphate: a structural approach to biologically relevant species

“…There are few studies that focus on the protonation and complexation abilities of Ins P s at the inframolecular level, and only a few reports on Ins P s analyzed from a structural point of view, with Ins P 3 and Ins P 6 being the most studied so far. 12 – 18 …”

“…There are few studies that focus on the protonation and complexation abilities of InsPs at the inframolecular level, and only a few reports on InsPs analyzed from a structural point of view, with InsP 3 and InsP 6 being the most studied so far. [12][13][14][15][16][17][18] For the second most abundant member of the InsPs family, myo-inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P 5 , Fig. 1), the structural information published is still scarce.…”

Inositol Phosphates Influence Iron Uptake in Caco-2 Cells

“…The 1,2,3 (equatorial-axial-equatorial) triphosphate grouping has been shown to be the orientation forming the strongest complex with Fe 3+ (Hawkins et al, 1993). Stronger binding of cations (Cu 2+ , Zn 2+ , Fe 2+ , Fe 3+ ) was shown for InsP 3 with three vicinical phosphates (Ins(1,2,6)P 3 ) than three alternated phosphates (Ins(1,3,5)P 3 or Ins(2,4,6)P 3 ) (Mernissi-Arifi et al, 1994). In the case of three alternated phosphate groups, one group in axial position (Ins(2,4,6)P 3 ) largely contributed to complex stabilization.…”

“…Brune et al (1992) and Rossander et al (1992) found a strong negative correlation between Fe and Zn absorption and the sum of InsP 3 -InsP 6 in processed foods, suggesting a contributing negative effect of the less phosphorylated inositol phosphates on mineral absorption. The binding affinity of cations (Cu 2+ , Zn 2+ , Fe 2+ , Fe 3+ ) to inositol phosphates has been shown to be affected by the orientation of the phosphate groups (Hawkins et al, 1993;Mernissi-Arifi et al, 1994). Since the positions of the phosphate groups on the inositol ring plays an important role in the binding of minerals, this might affect mineral absorption as well.…”

Insight into the protonation and K(I)-interaction of the inositol 1,2,3-trisphosphate as provided by 31P NMR and theoretical calculations

“…There are few studies focusing on the protonation state at an inframolecular level and/or the intrinsic 0022-2860/$ -see front matter Ó 2010 Elsevier B.V. All rights reserved. doi:10.1016/j.molstruc.2010.11.050 metal complexation properties of myo-inositol phosphates [9][10][11][12]. In particular for Ins(1,2,3)P 3 , a molecule whose biological function is still controversial, some information regarding the intrinsic acid-base properties has been reported [12], although the data were acquired in the presence of large amounts of K(I), which substantially interacts with this ligand in weakly acid to basic media [4].…”