Complexation of tropane alkaloids by cyclodextrins

Asztemborska, Monika; Ceborska, Magdalena; Pietrzak, Mariusz

doi:10.1016/j.carbpol.2019.01.011

Cited by 15 publications

(5 citation statements)

References 26 publications

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“…2 and S2) indicated that the two components are not physically mixed but have undergone a significant alteration of their vibration properties (mainly atropine and scopolamine) following their inclusion in the CD cavity with the subsequent restricted dynamic motion. This observation is in accordance with other studies that have been performed in CD inclusion complexes and by a MD and docking simulations performed in this study (Asztemborska et al 2019;Mansouri et al 2013;Wszelaka-Rylik and Gierycz 2015).…”

Section: Ft-ir Characterization Of Hpβcd-tropane Alkaloids Inclusion Complexsupporting

confidence: 94%

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

et al. 2021

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Datura stramonium L. (Solanaceae) possesses a rich tropane alkaloids (TAs) spectrum. The plant contains, in particular, the allelopathic compounds scopolamine and atropine, which are poorly soluble in water, thus limiting their use in agrochemical formulations as biocidal and deterrent agents against herbivore insects. The efficacy of the hydrophobic TAs extracts could be increased with the improvement of their dissolution/leaching properties. This is important for improving screening and test performance and for elucidating the activity of environmentally friendly agricultural approaches, with new perspectives for the production and use of those biodegradable insecticidal products. The present study explores the aspects of atropine and scopolamine complexation with cyclodextrin (CDs) through FT-IR and UV–Vis spectroscopies. In addition, the structures of the inclusion complex of atropine, scopolamine and β-CD have been investigated by molecular modeling techniques. The results obtained indicate that β-CDs are a promising carriers for improving the properties of TAs, therefore increasing their application potential in agrochemical formulations. Graphic abstract

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Section: Ft-ir Characterization Of Hpβcd-tropane Alkaloids Inclusion Complexsupporting

confidence: 94%

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

et al. 2021

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“…Scientists all over the world have thoroughly examined and characterized the entrapment of pure natural compounds (e.g., polyphenols [ 19 , 20 ], flavonoids [ 21 , 22 ], alkaloids [ 23 , 24 , 25 ], terpenoids [ 26 ]), EOs [ 27 , 28 ] (e.g., tee tree oil [ 29 ], oregano [ 30 ], Eucalyptus staigeriana [ 31 ]) and extracts (e.g., propolis [ 32 , 33 ], olive leaves [ 34 ], Chimonanthus praecox extract [ 35 ]) in α-, β- or γ-CDs or modified CDs for several applications, revealing significantly improved properties to the final complexes [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

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Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers’ formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

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“…The improvement of electrophoretic separation may be achieved by addition of cyclodextrins (CD). Asztemborska et al [ 26 ] used native cyclodextrins (α, β and γ) and their non-ionic derivatives to investigate complex formation with Atr and Sco. The results indicate that the separation of particular enantiomers of Atr and Sco is challenging, but CDs may be used to increase the separation ability of the BGEs.…”

Section: Resultsmentioning

confidence: 99%

Development of CE-C4D Method for Determination Tropane Alkaloids

et al. 2021

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A fast method for the determination of tropane alkaloids, using a portable CE instrument with a capacitively coupled contactless conductivity detector (CE-C4D) was developed and validated for determination of atropine and scopolamine in seeds from Solanaceae family plants. Separation was obtained within 5 min, using an optimized background electrolyte consisting of 0.5 M acetic acid with 0.25% (w/v) β-CD. The limit of detection and quantification was 0.5 µg/mL and 1.5 µg/mL, respectively, for both atropine and scopolamine. The developed method was validated with the following parameters—precision (CV): 1.07–2.08%, accuracy of the assay (recovery, RE): 101.0–102.7% and matrix effect (ME): 92.99–94.23%. Moreover, the optimized CE-C4D method was applied to the analysis of plant extracts and pharmaceuticals, proving its applicability and accuracy.

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Complexation of tropane alkaloids by cyclodextrins

Cited by 15 publications

References 26 publications

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Development of CE-C4D Method for Determination Tropane Alkaloids

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