Complexation of resveratrol with cyclodextrins: Solubility and antioxidant activity

Lu, Zhong; Cheng, Bo; Hu, Yunjie; Zhang, Youhong; Zou, Guolin

doi:10.1016/j.foodchem.2008.04.042

Cited by 174 publications

(99 citation statements)

References 18 publications

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“…However, due to hydrophobicity, dissolution is a ratelimiting step for in vivo absorption, which constitutes the serious problem for oral bioavailability (18), the extensive research has been carried out to overcome this problem (19,20).…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

et al. 2011

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Abstract. The aim of this work was to increase the solubility, stability and permeation of resveratrol by complexation with cyclodextrin-based nanosponges (NS). Nanosponges are recently developed hypercross-linked cyclodextrin polymers nanostructured to form three-dimensional networks; they are obtained by reacting cyclodextrin with a cross-linker such as carbonyldiimidazole. They have been used to increase the solubility and stability of poorly soluble actives. This study aimed at formulating complexes of resveratrol with β-cyclodextrin nanosponges in different weight ratios. DSC, FTIR and Xray powder diffraction (XRPD) studies confirmed the interaction of resveratrol with NS. XRPD showed that the crystallinity of resveratrol decrease after encapsulation. The particle sizes of resveratrol-loaded NS are in between 400 to 500 nm with low polydispersity indices. Zeta potential is sufficiently high to obtain a stable colloidal nanosuspension. TEM measurement also revealed a particle size around 400 nm for NS complexes. The in vitro release and stability of resveratrol complex were increased compared with plain drug. Cytotoxic studies on HCPC-I cell showed that resveratrol formulations were more cytotoxic than plain resveratrol. The permeation study indicates that the resveratrol NS formulation showed good permeation in pigskin. The accumulation study in rabbit mucosa showed better accumulation of resveratrol NS formulation than plain drug. These results signify that resveratrol NS formulation can be used for buccal delivery and topical application.

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Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

et al. 2011

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“…[8][9][10][11][12] RSV has demonstrated potential cancer chemopreventive properties by suppressing the proliferation process at the initiation, promotion, and progression stages of several cancer cell lines, such as lymphocytes, breast, glia, and skin and prostate tumor cells. [12][13][14] Despite promising results in preclinical settings, the extensive use of RSV has met only limited success, largely due to its instability, 15 poor solubility, 16 inefficient systemic delivery, and low bioavailability. 17 RSV is more biologically active compared to its cis (Z)-isoform, and therefore requires the formulation of a finished protecting product, able to retain the structural integrity of the bioactive molecules until consumption or administration.…”

Section: Introductionmentioning

confidence: 99%

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Sanna¹,

Roggio²,

Siliani³

et al. 2012

IJN

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Background:Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may be achieved via suitable carriers able to associate controlled release and protection. In this context, nanotechnology is proving to be a powerful strategy. In this study, we developed novel cationic chitosan (CS)-and anionic alginate (Alg)-coated poly(d,l-lactide-co-glycolide) nanoparticles (NPs) loaded with the bioactive polyphenolic trans-(E)-resveratrol (RSV) for biomedical applications. Methods: NPs were prepared by the nanoprecipitation method and characterized in terms of morphology, size and zeta potential, encapsulation efficiency, Raman spectroscopy, swelling properties, differential scanning calorimetry, and in vitro release studies. The protective effect of the nanosystems under the light-stressed RSV and long-term stability were investigated. Results: NPs turned out to be spherical in shape, with size ranging from 135 to about 580 nm, depending on the composition and the amount of polyelectrolytes, while the encapsulation efficiencies increased from 8% of uncoated poly(d,l-lactide-co-glycolide) (PLGA) to 23% and 32% of Alg-and CS-coated PLGA NPs, respectively. All nanocarriers are characterized by a biphasic release pattern, and more effective controlled release rates are obtained for NPs formulated with higher polyelectrolyte concentrations. Stability studies revealed that encapsulation provides significant protection against light-exposure degradation, by reducing the trans-cis photoisomerization reaction. Moreover, the nanosystems are able to prevent the degradation of trans isoform and the leakage of RSV from the carrier for a period of 6 months. Conclusion: Our findings indicated that the newly developed CS-and Alg-coated PLGA NPs are suitable to be used for the delivery of bioactive RSV. The encapsulation of RSV into optimized polymeric NPs provides improved drug loading, effective controlled release, and protection against light-exposure degradation, thus opening new perspectives for the delivery of bioactive related phytochemicals to be used for (nano)chemoprevention/chemotherapy.

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“…Recently, Res has drawn great attentions because of its beneficial effects against many diseases such as cancer (Signorelli & Ghidoni, 2005), cardiovascular disease (Vella, Bowen, & Fenning, 2008), inflammatory disease (Kang et al, 2009), and platelet aggregation (Pace-Asciak, Hahn, Diamandis, Soleas, & Goldberg, 1995). However, Res has some drawbacks of unstabilization (Signorelli & Ghidoni, 2005), poorly water soluble (Lu, Cheng, Hu, Zhang, & Zou, 2009), and short biological half time (Juan, Buenafuente, Casals, & Planas, 2002), all of which limit the utilisation of Res in food and pharmaceutical industries. In order to overcome such drawbacks, incorporation of Res into a polymer matrix is one of the useful methods available.…”

Section: Introductionmentioning

confidence: 99%

Vanillin cross-linked chitosan microspheres for controlled release of resveratrol

et al. 2010

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Complexation of resveratrol with cyclodextrins: Solubility and antioxidant activity

Cited by 174 publications

References 18 publications

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Vanillin cross-linked chitosan microspheres for controlled release of resveratrol

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Complexation of resveratrol with cyclodextrins: Solubility and antioxidant activity

Cited by 174 publications

References 18 publications

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study

Development of novel cationic chitosan- and anionic alginate&ndash;coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Vanillin cross-linked chitosan microspheres for controlled release of resveratrol

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Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol