Complexation of Organic Substances in Aqueous Solution by Hydroxyaromatic Acids and Their Salts II.

Binding Specificity between Small Organic Solutes in Aqueous Solution: Classification of Some Solutes into Two Groups According to Binding Tendencies

“…The observed binding between organic molecules in water is, however, firmly believed to be strictly physical in nature. As pointed out earlier (1,5,6), the observed intensity of binding cannot be rationalized on the basis of simple charge-transfer-type interactions (the binding constants are extremely low in alcohol, dioxane, and purely nonpolar solvents), dispersion forces (little or no interactive tendency is evident among systems of low polarizability), hydrophobic associations (very small contributions from flexible alkyl side chains), or hydrogen bonding alone. The matter is, of course, complicated by the possible interplay of different interacting forces.…”

The metabolism of 5,5‘-methylenedisalicylic acid in various species

“…It forms complexes with drugs such as phenacetin, theophylline and prednisolone (Higuchi & Pisano, 1964) and salts with organic bases. It forms complexes with drugs such as phenacetin, theophylline and prednisolone (Higuchi & Pisano, 1964) and salts with organic bases.…”