Complexation of drug amifampridine with Cu(ii), Zn(ii) and Cd(ii) ions, and its dimerization with the magic of Mn(ii) salts. Potential anti-COVID-19 and anticancer activities

Abstract

Dimerization via C–H activation with Mn(ii) ions, Complexation with Cu(ii), Zn(ii) and Cd(ii) ions.

A new Cu(ii) complex derived from the reaction between tris(2-aminoethyl)amine and Cu(i)-activated acetonitrile with potent anticancer activity against some cell lines and high affinity for the essential proteins of SARS-CoV-2

“…25 Furthermore, the exposure of copper to the human coronavirus 229E destroyed the viral genomes and irreversibly affected virus morphology, including the disintegration of the envelope and the dispersal of surface spikes. 26 In this work, similar to our previous works, 27,28 we aimed to synthesize the tris(2-aminoethyl)aminebased Cu(I) complex of drug amifampridine (AMP) as a drug vehicle. But interestingly, a new Cu(II) complex was formed without coordination of the AMP.…”