Complexation of carboxylic acids and anions by alpha and beta cyclodextrins

Thermodynamic investigation of the interaction between cyclodextrins and preservatives — Application and verification in a mathematical model to determine the needed preservative surplus in aqueous cyclodextrin formulations

“…Making the same titration at e.g. pH 7 was not possible due to the low complexation constant of the charged form of benzoic acid, reported to be 10 to 60 M −1 in the literature (Siimer et al, 1987;Larsen et al, 1998;Gelb and Schwartz, 1989;Dhillon et al, 1995). The complexation constants determined in the present work were located in the range of 410-3544 M −1 , which were comparable with the reported values from the literature given the above-mentioned prerequisites.…”

“…d Determined by calometry in flow-mix cells at 30°C from Siimer and Kurvits (1989). e Determined by potentiometric titration from Gelb and Schwartz (1989). f Determined by UV-spectrophotometry from Belyakova and Lyashenko (2008).…”

Spontaneous association of hydrophobized dextran and poly-β-cyclodextrin into nanoassemblies.

“…No change in the surface tension was observed: obviously the native β-CDs were unable to sequestrate the hydrophobic anchors of the hydrophobized dextran and to solubilize the polymer into the subphase. Since it was previously demonstrated that CD cavities do interact with alkyl moieties [43,59,60], it may be inferred from this experiment that the interaction between the C 12 chains grafted to the polysaccharide and the native CDs did not result in a sufficiently strong driving force allowing extraction of the polymer from the air/water interface. This failure of the native β-CDs to modify the interface of the MD solution allowed understanding the mechanism of dextran depletion by pβCD from the interface.…”

How does β-cyclodextrin affect oxygen solubility in aqueous solutions of sodium perfluoroheptanoate?

“…Cyclodextrins originate a large variety of supramolecular host-guest inclusion compounds with a diversity of organic and inorganic guests including aromatic and aliphatic hydrocarbons [11][12][13][14][15][16], aromatic compounds containing varying degrees of fluorine substitution [17], and perfluorocarbon-substituted surfactants [18][19][20][21]. In the last case, studies have concluded that the inclusion strongly depends on the cavity diameter [22][23][24].…”