Complexation of Ca2+ and Mg2+ with aminopropylidenebisphosphonic acids in aqueous and micellar solutions of cetylpyridinium chloride

Cong, Hoan Le; Boichenko, Alexander P.; Levin, I. V.; Матвеева, А. Г.; Loginova, Lidia P.

doi:10.1016/j.molliq.2010.03.014

Cited by 12 publications

(1 citation statement)

References 24 publications

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“…The dissociation of the cationic species H 6 A + , leading to the neutral zwitterion form H 5 A 0,± (p K a1 = 1.33), has been reported despite its minor presence in the equilibrium state H 5 A . The first work presenting the dissociation constants of H 5 A is dated at the end of the 1970, which is reproduced by referral databases such as the Merck Index despite the existence of further references. ,− ,− The values present in a more recent work are p K a2 = 2.24(1), p K a3 = 6.38(3), p K a4 = 10.68(6), and p K a5 = 11.4(2). Therefore, at the physiological pH (6–8) of the small intestine, the predominate species is H 3 A 2−,± (pH > 6.38) or H 4 A −,± (pH < 6.38).…”

Section: Introductionmentioning

confidence: 99%

Solid-State Phase Transition Mechanism and Physical–Chemical Study of the Crystal Forms of Monosodium Alendronate: Trihydrate versus Anhydrate

Gonzaga

Viana

2016

Crystal Growth & Design

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Alendronic acid is one of the most effective diphosphonate compounds used for clinical treatment of bone disorders. It is administered orally as its monosodium salt, for which hydrate and anhydrous crystal forms are known. The monosodium alendronate trihydrate form (NaH 4 A•3H 2 O) is incorporated into medicines as the Active Pharmaceutical Ingredient (API). The NaH 4 A•3H 2 O form can be dehydrated at temperatures above 115 °C, resulting in the anhydrous form (NaH 4 A). Although the crystal structures of both forms have already been reported, an investigation of the reversible dehydration/hydration solid-phase transition is presented here for the first time. A solid-state mechanism for the phase transition, which involves the reversible dehydration−hydration of the NaH 4 A•3H 2 O and NaH 4 A forms, is also proposed. A systematic study comparing the equilibrium solubility and discriminatory intrinsic dissolution of the NaH 4 A•3H 2 O and NaH 4 A forms is included. To achieve this goal, an alternative method of quantifying alendronate anions released from the crystal forms into solution, flame photometry, is proposed and validated. The stability and interconversion of the NaH 4 A•3H 2 O and NaH 4 A forms are probed by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy−attenuated total reflectance (FTIR-ATR), and powder X-ray diffraction (PXRD).

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Section: Introductionmentioning

confidence: 99%

Solid-State Phase Transition Mechanism and Physical–Chemical Study of the Crystal Forms of Monosodium Alendronate: Trihydrate versus Anhydrate

Gonzaga

Viana

2016

Crystal Growth & Design

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Insight into the Mechanisms of Scale Inhibition: A Case Study of a Task‐Specific Fluorescent‐Tagged Scale Inhibitor Location on Gypsum Crystals

Oshchepkov

Kamagurov²,

Tkachenko

et al. 2019

ChemNanoMat

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Scaling in reverse osmosis facilities, boilers, heat exchangers, evaporation plants, and oilfield applications is a serious problem worldwide. In order to provide a new insight into the mechanism of the scale formation and inhibition, a novel fluorescent‐tagged bisphosphonate scale inhibitor 1‐hydroxy‐7‐(6‐methoxy‐1,3‐dioxo‐1H‐benzo[de]isoquinolin‐2(3H)‐yl)heptane‐1,1‐diyl‐di(phosphonic acid), (HEDP−F) was synthesized and used for fluorescent microscope visualization of gypsum crystal formation in supersaturated aqueous solutions. The visualization of HEDP−F location on gypsum crystals has demonstrated that the bisphosphonate molecules do not act as they are expected to do according to the current scale inhibition theory. At ambient temperature the gypsum macrocrystals are found to form, and then to grow without visible sorption of bisphosphonate on the crystal edges or any other gypsum crystal growth centers. A tentative nonconventional mechanism of scale inhibition in the bulk supersaturated aqueous solutions of gypsum is proposed.

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Electrochemical and spectroscopic investigations of selected N -heteroalkylaminomethylenebisphosphonic acids with Pb(II) ions

Dobosz

Spychała

Ptak

et al. 2016

Coordination Chemistry Reviews

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Complexation of Ca2+ and Mg2+ with aminopropylidenebisphosphonic acids in aqueous and micellar solutions of cetylpyridinium chloride

Cited by 12 publications

References 24 publications

Solid-State Phase Transition Mechanism and Physical–Chemical Study of the Crystal Forms of Monosodium Alendronate: Trihydrate versus Anhydrate

Solid-State Phase Transition Mechanism and Physical–Chemical Study of the Crystal Forms of Monosodium Alendronate: Trihydrate versus Anhydrate

Insight into the Mechanisms of Scale Inhibition: A Case Study of a Task‐Specific Fluorescent‐Tagged Scale Inhibitor Location on Gypsum Crystals

Electrochemical and spectroscopic investigations of selected N -heteroalkylaminomethylenebisphosphonic acids with Pb(II) ions

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