Complexation of Apple Antioxidants: Chlorogenic Acid, Quercetin and Rutin by β-Cyclodextrin (β-CD)

́Álvarez-Parrilla, Emilio; Rosa, Laura A. de la; Torres-Rivas, Francisco; Rodrigo-García, Joaquín; González‐Aguilar, Gustavo A.

doi:10.1007/s10847-005-1620-z

Cited by 85 publications

(61 citation statements)

References 37 publications

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“…However, as shown in Figure 2a, and in agreement with Pulido et al (2000) and Alvarez-Parrilla et al (2005), the reduction of Fe 3+ to Fe 2+ in the presence of the mushroom extract follows a slow kinetic mechanism, and even after 30 min the reaction was not totally completed. For this reason, FRAP values were determined at 30 min, as suggested in the literature (Pulido et al, 2000;Alvarez-Parrilla et al, 2005). When the FRAP values determined at 4 and 30 min were compared, a 32-97 % increment was observed.…”

Section: Antioxidant Activitysupporting

confidence: 83%

“…Antioxidant capacity Antioxidant capacity was determined by the ferric reducing/antioxidant power assay (FRAP) according to Benzie and Strain (1996) and modified by Alvarez-Parrilla et al (2005), with slight modifications. FRAP reagent was daily prepared and kept at 37 °C, by mixing 0.3 M acetate buffer, pH 3.6 with 10 mM 2,4,6-tripyridyl-s-triazine (TPTZ, Acrôs Organics, USA) solution in 40 mM HCl plus 20 mM FeCl 3 ·6H 2 O, at a 10:1:1 ratio.…”

Section: Portabellamentioning

confidence: 99%

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Total Phenols and Antioxidant Activity of Commercial and Wild Mushrooms From Chihuahua, Mexico Fenoles Totalesy Capacidad Antioxidante De Hongos Comercialesy Silvestres De Chihuahua, México

́Álvarez-Parrilla

Rosa

Martínez

et al. 2007

Ciencia y Tecnologia Alimentaria

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Three wild edible mushrooms (Agaricus sp., Boletus sp., and Macrolepiota sp.) from the North of Mexico (Chihuahua state) and two commercial species (Agaricus bisporus white strain and Portabella: Agaricus bisporus brown strain) were analyzed to determine their proximate composition, total phenols and antioxidant activity. Wild mushrooms presented lower humidity values with respect to commercial species. Other proximate parameters such as total protein, lipids, ashes and carbohydrates were similar to those reported for edible mushrooms. Total phenols and antioxidant activity (Ferric Reducing/ Antioxidant Power assay, FRAP) were determined from 80 % methanol extracts. Wild Mushrooms had higher phenol content and antioxidant capacity than commercial mushrooms. A direct correlation between phenols and antioxidant activity (r 2 = 0.986) was observed. Due to these characteristics, wild mushrooms could be considered as a complement in the diet for the health benefits they present. ResumenSe analizó la composición proximal, fenoles totales y capacidad antioxidante, de tres hongos silvestres (Agaricus sp., Boletus sp., and Macrolepiota sp.) del norte de México (Chihuahua) y dos comerciales (Agaricus bisporus cepa blanca and Portalella: Agaricus bisporus cepa café). Los hongos silvestres presentaron valores menores de humedad que los comerciales. Los demás parámetros proximales (proteínas, lípidos, cenizas y carbohidratos totales) fueron similares a los reportados para hongos silvestres. La concentración de fenoles totales y actividad antioxidante (Ferric Reducing/Antioxidant Power assay, FRAP) se determinaron a partir de extractos con metanol al 80 %. Los hongos silvestres presentaron valores más altos en fenoles totales y actividad antioxidante, frente a los hongos comerciales. Se observó una correlación directa (r 2 = 0,986) entre fenoles totales y actividad antioxidante. Estas características de los hogos silvestres hacen que puedan ser considerados, como complemento de la dieta ya que puede presentar buenos beneficios en la salud.

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Section: Antioxidant Activitysupporting

confidence: 83%

Section: Portabellamentioning

confidence: 99%

Total Phenols and Antioxidant Activity of Commercial and Wild Mushrooms From Chihuahua, Mexico Fenoles Totalesy Capacidad Antioxidante De Hongos Comercialesy Silvestres De Chihuahua, México

́Álvarez-Parrilla

Rosa

Martínez

et al. 2007

Ciencia y Tecnologia Alimentaria

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“…By contrast, exceptionally high PR was displayed mainly by the extracts obtained with aqueous ethanol (Figure 3), and no consistency with AAR was found. The role of β-CD in the expression of antioxidant effects should not be overlooked, because it has been demonstrated that β-CD complexes with rosmarinic acid [37], quercetin and rutin [38], but also hydroxypropyl β-CD complexes with polyphenols such as chlorogenic acid [39] and quercetin [36], showed significantly higher antioxidant activity compared with the non-encapsulated polyphenols. This phenomenon has also been demonstrated for chlorogenate-rich coffee extracts [40].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Combination of Lactic Acid-Based Deep Eutectic Solvents (DES) with β-Cyclodextrin: Performance Screening Using Ultrasound-Assisted Extraction of Polyphenols from Selected Native Greek Medicinal Plants

et al. 2017

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Abstract:A series of novel L-lactic acid-based deep eutectic solvents (DES) were tested for polyphenol extraction performance, using organically grown, native Greek medicinal plants. The extractions were ultrasonically-assisted and the effect of the addition of β-cyclodextrin (β-CD) as extraction booster was also tested, at a concentration of 1.5% (w/v). The estimation of total polyphenol yield (Y TP ) suggested that DES composed of L-lactic acid and nicotinamide and L-lactic acid and L-alanine, both at a molar ratio of 7:1, are promising solvents giving significantly higher yields compared with 60% (v/v) aqueous ethanol and water. However, when β-CD was combined with DES comprised of L-lactic acid and ammonium acetate (molar ratio 7:1), the extraction yields obtained in some instances were equal of even higher. The pattern was not consistent when the yield in total flavonoids (Y TFn ) was considered, indicating water, 60% (v/v) aqueous ethanol and L-lactic acid:sodium acetate (molar ratio 7:1) to be the most efficient solvents. In this case, the effect of β-CD was of rather lower magnitude. The examination of the antioxidant activity of the extracts generated showed that there is a close correlation mainly with their concentration in total polyphenols.

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“…Most quercetin/β-cyclodextrin solid complexes are prepared in liquid media, (aqueous solution submitted to freeze-drying (12,14,18), co-evaporation (11,16), or thin layer (11) methods) or semisolid media (kneading method (11,14,16,19)). However, no study to date has used a factorial design to assess the influence of operating conditions such as temperature, stirring time, and excess amount of quercetin on the complexation of quercetin with β-cyclodextrin.…”

Section: Introductionmentioning

confidence: 99%

Quercetin/β-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture

et al. 2009

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Abstract. The present study was designed to investigate the influence of operating conditions (temperature, stirring time, and excess amount of quercetin) on the complexation of quercetin with β-cyclodextrin using a 2 3 factorial design. The highest aqueous solubility of quercetin was reached under the conditions 37°C/24 h/6 mM of quercetin. The stoichiometric ratio (1:1) and the apparent stability constant (Ks=230 M −1 ) of the quercetin/β-cyclodextrin complex were determined using phase-solubility diagrams. The semi-industrial production of a 1:1 quercetin/β-cyclodextrin solid complex was carried out in aqueous solution followed by spray-drying. Although the yield of the spray-drying process was adequate (77%), the solid complex presented low concentration of quercetin (0.14%, w/w) and, thus, low complexation efficiency. The enhancement of aqueous solubility of quercetin using this method was limited to 4.6-fold in the presence of 15 mM of β-cyclodextrin. Subsequently, an inclusion complex was prepared via physical mixture of quercetin with β-cyclodextrin (molar ratio of 1:1 and quercetin concentration of 23% (w/w)) and characterized using infrared spectroscopy, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and scanning electron microscopy analyses. The enhancement of aqueous solubility of quercetin using this method was 2.2-fold, similar to that found in the complex prepared in aqueous solution before the spray-drying process (2.5-fold at a molar ratio of 1:1, i.e., 6 mM of quercetin and 6 mM of β-cyclodextrin).

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Complexation of Apple Antioxidants: Chlorogenic Acid, Quercetin and Rutin by β-Cyclodextrin (β-CD)

Cited by 85 publications

References 37 publications

Total Phenols and Antioxidant Activity of Commercial and Wild Mushrooms From Chihuahua, Mexico Fenoles Totalesy Capacidad Antioxidante De Hongos Comercialesy Silvestres De Chihuahua, México

Total Phenols and Antioxidant Activity of Commercial and Wild Mushrooms From Chihuahua, Mexico Fenoles Totalesy Capacidad Antioxidante De Hongos Comercialesy Silvestres De Chihuahua, México

Combination of Lactic Acid-Based Deep Eutectic Solvents (DES) with β-Cyclodextrin: Performance Screening Using Ultrasound-Assisted Extraction of Polyphenols from Selected Native Greek Medicinal Plants

Quercetin/β-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture

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