Complexation and oxidation of Flutamide with Fe 3+ and 1,10-phenanthroline: Few analytical applications

Abstract

A simple and sensitive spectrophotometric method has been proposed for the determination of flutamide (FLD). The method is based on its complexation and oxidation of FLD by Fe 3+ and 1,10-phenanthroline. Two sets of condition were established. In the first set only FLD reacted with Fe 3+ ion, while in the second one FLD was oxidized by Fe 3+ in the presence of 1,10-phenanthroline. The complexation and oxidation methods were monitored spectrophotometrically. All variables affecting the development of the color were investigated and the conditions obeying Beer's law were optimized. Plots of absorbance against concentration in both methods were rectilinear over the ranges 0.5-10 and 0.5-1.5 lg mL À1 , with mean recoveries of 99.51 and 99.83 for methods A and B respectively. The limits of detection for procedures 1 and 2 are 0.332 and 0.726 lg mL À1 1, respectively. Both the methods were successfully applied for the determination of the FLD in its dosage form.

A facile graphene oxide based sensor for electrochemical detection of prostate anti-cancer (anti-testosterone) drug flutamide in biological samples

“…In addition to this, a comparison of the proposed sensor with other reported methods (including electrochemical methods) for the detection of utamide has also been carried out, and the results are summarized in Table S1. † [40][41][42][43][44][45] Compared to other electrochemical methods, the proposed method demonstrated higher sensitivity, wide linear response range, lower LOD and very simple electrode fabrication process. Moreover, the proposed sensor was applied in real samples such as in rat brain, kidney and human blood serum samples.…”

Stability of Vanadium Chalcone Complexes

“…Chalcones use for the treatment of chronic diseases which involve inflammatory processes, for example, diabetes mellitus [2]. The study of chalcone derivatives has become of much interest in recent years on account of their antibacterial, antiviral activities [3]. Many chalcones based have been recognized in a number of screening assays for modulating important pathways or molecular targets in cancer [4,5].…”