Complex Tuning of Physical Properties of Hyperbranched Polyglycerol‐Based Bioink for Microfabrication of Cell‐Laden Hydrogels

Hong, Jisu; Shin, Yoonkyung; Kim, Suntae; Lee, Jiseok; Cha, Chaenyung

doi:10.1002/adfm.201808750

Cited by 31 publications

(24 citation statements)

References 53 publications

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“…The maximum reported printing speeds are ~150 mm/s for extrusion bioprinting, ~200 mm/s for inkjet bioprinting, and ~20 mm/s–~500 mm/s for laser-based bioprinting[ 84 ]. Droplet and laser-assisted bioprinting technologies[ 85 - 87 ] also show higher resolution and precision capabilities than the extrusion bioprinting[ 88 ]. However, the cost and required expertise for operation may be preventing the widespread use of droplet and laser-based methods[ 89 , 90 ].…”

Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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This scientometric analysis of 393 original papers published from January 2000 to June 2019 describes the development and use of bioinks for 3D bioprinting. The main trends for bioink applications and the primary considerations guiding the selection and design of current bioink components (i.e., cell types, hydrogels, and additives) were reviewed. The cost, availability, practicality, and basic biological considerations (e.g., cytocompatibility and cell attachment) are the most popular parameters guiding bioink use and development. Today, extrusion bioprinting is the most widely used bioprinting technique. The most reported use of bioinks is the generic characterization of bioink formulations or bioprinting technologies (32%), followed by cartilage bioprinting applications (16%). Similarly, the cell-type choice is mostly generic, as cells are typically used as models to assess bioink formulations or new bioprinting methodologies rather than to fabricate specific tissues. The cell-binding motif arginine-glycine-aspartate is the most common bioink additive. Many articles reported the development of advanced functional bioinks for specific biomedical applications; however, most bioinks remain the basic compositions that meet the simple criteria: Manufacturability and essential biological performance. Alginate and gelatin methacryloyl are the most popular hydrogels that meet these criteria. Our analysis suggests that present-day bioinks still represent a stage of emergence of bioprinting technology.

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Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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“…Taking advantage of these properties, Hong et al recently developed a bioink based on acrylic HPG that allows control of mechanical properties of hydrogels with degree of acrylate substitution, molecular weight, and concentration of HPG (Figure 12). 80 The degree of acrylate substitution (i.e., acrylate/HPG ratio) changed the hydrophobic/hydrophilic character of the polymer, while the molecular weight changed the chain length of HPG branches. These tunable physical properties could in turn influence the interaction with other gel-forming monomers (or macromers), leading to controlling the mechanical properties of resulting hydrogels.…”

Section: Poly(ethylene Glycol)mentioning

confidence: 99%

Advanced Polymer-Based Bioink Technology for Printing Soft Biomaterials

Lee

Cha

2020

Macromol. Res.

Self Cite

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Remarkable advancement in 3D printing technology in recent years has already transformed many aspects of industrial manufacturing. The immense potential of 3D printing is already being explored in state-of-the-art biomedical research field. Often termed "bioprinting", 3D printing is utilized to generate biological structures with high resolution and specificity for tissue engineering and regenerative medical applications. With the maturation of bioprinting apparatus, now the focus is shifting to engineering "bioinks" that can accommodate the versatility of biological systems, while still maintaining their printability. In this review, bioink technologies based on various polymers to produce soft biomaterials, such as hydrogels and elastomers, having a diverse array of physicochemical and bioactive properties are introduced and highlighted.

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“…The mechanical properties of hydrogels used for tissue engineering are generally controlled by different factors such as the cross-link density [4,5] and molecular weight distribution [6]. To solve this problem, many researchers have studied strategies for enhancing the mechanical properties of hydrogels with physical or chemical methods [7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Mechanically Reinforced Gelatin Hydrogels by Introducing Slidable Supramolecular Cross-Linkers

et al. 2019

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Tough mechanical properties are generally required for tissue substitutes used in regeneration of damaged tissue, as these substitutes must be able to withstand the external physical force caused by stretching. Gelatin, a biopolymer derived from collagen, is a biocompatible and cell adhesive material, and is thus widely utilized as a component of biomaterials. However, the application of gelatin hydrogels as a tissue substitute is limited owing to their insufficient mechanical properties. Chemical cross-linking is a promising method to improve the mechanical properties of hydrogels. We examined the potential of the chemical cross-linking of gelatin hydrogels with carboxy-group-modified polyrotaxanes (PRXs), a supramolecular polymer comprising a poly(ethylene glycol) chain threaded into the cavity of α-cyclodextrins (α-CDs), to improve mechanical properties such as stretchability and toughness. Cross-linking gelatin hydrogels with threading α-CDs in PRXs could allow for freely mobile cross-linking points to potentially improve the mechanical properties. Indeed, the stretchability and toughness of gelatin hydrogels cross-linked with PRXs were slightly higher than those of the hydrogels with the conventional chemical cross-linkers 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS). In addition, the hysteresis loss of gelatin hydrogels cross-linked with PRXs after repeated stretching and relaxation cycles in a hydrated state was remarkably improved in comparison with that of conventional cross-linked hydrogels. It is considered that the freely mobile cross-linking points of gelatin hydrogels cross-linked with PRXs attenuates the stress concentration. Accordingly, gelatin hydrogels cross-linked with PRXs would provide excellent mechanical properties as biocompatible tissue substitutes exposed to a continuous external physical force.

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Complex Tuning of Physical Properties of Hyperbranched Polyglycerol‐Based Bioink for Microfabrication of Cell‐Laden Hydrogels

Cited by 31 publications

References 53 publications

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Advanced Polymer-Based Bioink Technology for Printing Soft Biomaterials

Mechanically Reinforced Gelatin Hydrogels by Introducing Slidable Supramolecular Cross-Linkers

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