Complex tone stimulation may induce binaural diplacusis with low-tone hearing loss

Ichimiya, Issei; Ichimiya, Hiroko

doi:10.1371/journal.pone.0210939

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Since morphological changes such as the collapse of stereocilia of outer hair cells ( Albers et al, 1987 ) or losing synapses in inner hair cells ( Valenzuela et al, 2020 ) fail to explain the correlation of EH and hearing loss, potential explanations have mainly focused on the mechanical impact caused by high endolymphatic pressure on endolymph components ( Oberman et al, 2017 ) and the function of the lymphatic sac ( Swinburne et al, 2018 ). Among those theories, the mechanical mechanism of high pressure in the endolymphatic duct explains the clinical hearing symptoms in early and mid-stage Méniere’s disease ( Ichimiya and Ichimiya, 2019 ), prompting the dehydration therapy for patients with MD. The effectiveness of dehydration therapy has not been strictly evaluated ( Quaranta et al, 2019 ), and a recent meta-analysis further concluded that it was unclear whether diuretics were effective ( Nevoux et al, 2018 ), even though patients have stated subjective perception improvements ( Ward et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

Wang

et al. 2022

Front. Cell. Neurosci.

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BackgroundEndolymphatic hydrops (EH) is considered as the pathological correlate of Menière’s disease (MD) and cause of hearing loss. The mechanism of EH, remaining unrevealed, poses challenges for formalized clinical trials.ObjectiveThis study aims to investigate the development of hearing loss, as well as the effect of dehydration treatment on EH animal models.MethodsIn this study, different severity EH animal models were created. The laser Doppler vibrometer (LDV) and auditory brainstem responses (ABR) were used to study the effects of EH and the dehydration effects of mannitol. The LDV was used to measure the vibration of the round window membrane (RWM) reflecting the changes in inner ear impedance. ABR was used to evaluate the hearing changes. Furthermore, tissue section and scanning electron microscopy (SEM) observations were used to analyze the anatomical change to the cochlea and outer hair cells.ResultsThe RWM vibrations decreased with the severity of EH, indicating an increase in the cochlear impedance. The dehydration therapy lowered the impedance to restore acoustic transduction in EH 10- and 20-day animal models. Simultaneously, the ABR thresholds increased in EH models and were restored after dehydration. Moreover, a difference in the hearing was found between ABR and LDV results in severe EH animal models, and the dehydration therapy was less effective, indicating a sensorineural hearing loss (SNHL).ConclusionEndolymphatic hydrops causes hearing loss by increasing the cochlear impedance in all tested groups, and mannitol dehydration is an effective therapy to restore hearing. However, SNHL occurs for the EH 30-day animal models, limiting the effectiveness of dehydration. Our results suggest the use of dehydrating agents in the early stage of EH.

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Section: Introductionmentioning

confidence: 99%

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

Wang

et al. 2022

Front. Cell. Neurosci.

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“…Diplacusis is not included in MDs diagnostic criteria, and it has not been properly described or studied in clinical practice. While Ichimiya and Ichimiya [41] recently reported that complex tone stimulation may induce binaural diplacusis when low-tone hearing is impaired, they could not suggest a specific condition or mechanism for the results. The simulation data show that a patient suffering diplacusis can perceive a low-frequency sound as a somewhat higher sound if it is caused by the EH.…”

Section: Discussionmentioning

confidence: 88%

Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

Lim

Cho

et al. 2021

ORL

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Hypothesis: The endolymphatic hydrops (EH) does not affect hearing loss significantly at low frequencies, whereas the hydrops affects the diplacusis. Background: There have been many arguments whether the EH cause the Meniere disease. Despite a lot of experimental studies to investigate the Meniere disease, there have been little modeling studies, which are helpful to understand the mechanism. Methods: A 3D finite element model of the human cochlea and the middle ear was used for investigation of the relationship between EH and hearing loss at low frequencies and diplacusis (2 specific symptoms of Meniere disease). While the cochlear geometry was simplified as a tapered box shape, the middle ear was based on the real geometry obtained from μCT images. EH is implemented by prestress on the basilar membrane surface in the simulation. Results: The EH did not cause significant hearing loss at low frequencies in both air- and bone-conducted hearing. Rather, this disorder caused a shift in best frequency (BF) position to the base at low frequencies below about 250 Hz. The BF shift can explain the diplacusis because a low-frequency sound can be perceived as a slightly higher frequency so that Meniere patients can perceive 2 different frequency sounds corresponding to a given single-frequency sound. Conclusion: The EH cannot be a sufficient condition for Meniere disease, whereas the hydrops can cause the diplacusis.

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“…Our previous study ( Ichimiya & Ichimiya, 2019 ) presented participants with harmonic complex tones that lacked low-tone components. Their perception of these tones revealed a pitch shift compared with the tone that was expected.…”

Section: Discussionmentioning

confidence: 99%

“…The experiments were performed as described in our previous studies ( Ichimiya & Ichimiya, 2019 ; Ichimiya & Ichimiya, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Simulation of hearing loss can induce pitch shifts for complex tones

Ichimiya,

Ichimiya

2023

PeerJ

Self Cite

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Background Most studies on pitch shift provoked by hearing loss have been conducted using pure tones. However, many sounds encountered in everyday life are harmonic complex tones. In the present study, psychoacoustic experiments using complex tones were performed on healthy participants, and the possible mechanisms that cause pitch shift due to hearing loss are discussed. Methods Two experiments were performed in this study. In experiment 1, two tones were presented, and the participants were asked to select the tone that was higher in pitch. Partials with frequencies less than 250, 500, 750, or 1,000 Hz were eliminated from the harmonic complex tones and used as test tones to simulate low-tone hearing loss. Each tone pair was constructed such that the tone with a lower fundamental frequency (F0) was higher in terms of the frequency of the lowest partial. Furthermore, partials whose frequencies were greater than 1,300 or 1,600 Hz were also eliminated from these test tones to simulate high-tone hearing loss or modified sounds that patients may hear in everyday life. When a tone with a lower F0 was perceived as higher in pitch, it was considered a pitch shift from the expected tone. In experiment 2, tonal sequences were constructed to create a passage of the song “Lightly Row.” Similar to experiment 1, partials of harmonic complex tones were eliminated from the tones. After listening to these tonal sequences, the participants were asked if the sequences sounded correct based on the melody or off-key. Results The results showed that pitch shifts and the melody sound off-key when lower partials are eliminated from complex tones, especially when a greater number of high-frequency components are eliminated. Conclusion Considering that these experiments were performed on healthy participants, the results suggest that the pitch shifts from the expected tone when patients with hearing loss hear certain complex tones, regardless of the underlying etiology of the hearing loss.

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Complex tone stimulation may induce binaural diplacusis with low-tone hearing loss

Cited by 5 publications

References 13 publications

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

Simulation of hearing loss can induce pitch shifts for complex tones

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