Complex stereotypies after right putaminal infarction: A case report

Maraganore, Demetrius M.; Lees, A. J.; Marsden, C. D.

doi:10.1002/mds.870060418

Cited by 53 publications

(25 citation statements)

References 4 publications

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“…Specifically, it is unlikely that isolated striatal loss results in the presence of sterotypies in FTLD, but it is the imbalance between cortical and striatal loss that is important. A single patient with stereotypies and an isolated right putamen infarct has also been reported, highlighting the fact that striatal damage is associated with stereotypies [12]. Although there was varying degree of cortical and striatal atrophy in those with and without stereotypies, the overlapping regions of grey matter atrophy is evidence against FTLD with and without stereotypies being separate diseases, but more akin to the fact that FTLD is not a homogeneous clinical syndrome.…”

Section: Discussionmentioning

confidence: 95%

Anatomic correlates of stereotypies in frontotemporal lobar degeneration

Josephs

Whitwell

Jack

2008

Neurobiology of Aging

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Stereotypies are common in frontotemporal lobar degeneration (FTLD) however the anatomical correlates of stereotypies are unknown. We therefore set out to compare patterns of grey matter volume loss in FTLD subjects with and without stereotypies. Subjects with a diagnosis of FTLD that met international consensus criteria were prospectively recruited and separated into those with and without stereotypies. MRI and cognitive measures were obtained and voxel-based morphometry was used to assess the patterns of grey matter volume loss in those with and without stereotypies, compared to a group of age-and gender-matched controls. Demographic and clinical features were similar between subjects with and without stereotypies. FTLD subjects with stereotypies had greater volume loss in the striatum compared to those without stereotypies. Those without stereotypies showed a more widespread and typical pattern of cortical frontotemporal loss. Stereotypies in FTLD are therefore associated with a greater proportion of striatal to cortical volume loss than those without stereotypies.

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Section: Discussionmentioning

confidence: 95%

Anatomic correlates of stereotypies in frontotemporal lobar degeneration

Josephs

Whitwell

Jack

2008

Neurobiology of Aging

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“…Children may report feeling satisfied and happy when exhibiting stereotypies, while others may be unaware of their own stereotypies and do not consider them to be disruptive or anxiety-provoking (Singer, 2013). However, in many cases, motor stereotypies can be self-injurious, socially offensive, or disruptive to desired activities (Maraganore et al, 1991; Symons et al, 2005). …”

Section: Introductionmentioning

confidence: 99%

Motor Stereotypies: A Pathophysiological Review

2017

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Motor stereotypies are common, repetitive, rhythmic movements with typical onset in early childhood. While most often described in children with autism spectrum disorder (ASD) and intellectual disability (ID), stereotypies can also present without developmental delay and persist into adulthood. Stereotypies are often disruptive and harmful, both physically and socially, and effective evidence-based treatments are lacking. This can be attributed, in part, to our incomplete knowledge of the underlying biological and environmental risk. Several studies implicate various neurotransmitters, brain circuits, anatomical loci, and pre- and post-natal environmental influences in stereotypy onset and symptom severity. However, there are few points of convergence among a relatively small number of studies, indicating that more research is needed to confirm the underlying bases of risk. Of particular note is the lack of published genetic studies of stereotypies, despite evidence for Mendelian inheritance patterns in some families. Focusing future studies on typically-developing children with primary motor stereotypies may be a useful approach to minimize potential biological, environmental, and genetic heterogeneity that could theoretically hinder consistent findings. Ultimately, a deeper understanding of the underlying biology and risk factors for motor stereotypies will lead us closer to more effective targeted therapies that will alleviate suffering in affected children.

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“…Thus, a caudate nucleus lesion may induce circling behavior. A caudate putamen lesion due to a malignant tumor can reportedly induce circling behavior in humans [27] . Intrastriatal 6-OHDA injection into the caudate putamen produced circling behavior in response to dopamine uptake depletion and decreased dopamine receptors [28] .…”

Section: Accuracy In Targeting and Behavioral Analysismentioning

confidence: 99%

Gamma Knife Radiosurgery Targeting Protocols for the Experiments with Small Animals

Tokumaru

Hayashi²,

Katayama³

et al. 2007

Stereotact Funct Neurosurg

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Background/Aims: Manipulation of brain functions via Gamma Knife (GK) irradiation would have numerous applications in clinical and experimental neurology. Methods: Alteration of brain functions in the unilaterally irradiated striatum was indexed through monitoring freely moving rat behaviors. Spontaneous activity and rotations on the apomorphine test, which can detect dopaminergic function imbalance, were indexed employing our behavior tracking system. The spatial distribution of necrotic lesions was explored using serial sections, and was assumed to represent the real foci of the GK target. Results: Distinct behavioral alterations corresponded to the precise locations of the lesions in various areas of the basal ganglia. Displacement of the irradiation sites in the anteromedial direction increased spontaneous activity, and posterolateral shift provoked circling behavior on the apomorphine test. Conclusion: Accurate positioning of the target is crucial for experimental GK irradiation locally focused on domains of a small brain such as that of the rat. Here, we propose a protocol for converting the ‘intended’ focus, based on brain map coordinates, to a ‘planned’ focus on the MR imaging coordinate system with the Régis-Valliccioni stereotactic frame.

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Complex stereotypies after right putaminal infarction: A case report

Cited by 53 publications

References 4 publications

Anatomic correlates of stereotypies in frontotemporal lobar degeneration

Anatomic correlates of stereotypies in frontotemporal lobar degeneration

Motor Stereotypies: A Pathophysiological Review

Gamma Knife Radiosurgery Targeting Protocols for the Experiments with Small Animals

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