Complex Sphingolipid Profiling and Identification of an Inositol Phosphorylceramide Synthase inDictyostelium discoideum
Stevanus A. Listian,
Matthijs Kol,
Edwin Ufelmann
et al.
Abstract:Dictyostelium discoideumis a professional phagocyte frequently used as experimental model to study cellular processes underlying the recognition, engulfment and infection course of microbial pathogens. Sphingolipids are abundant components of the plasma membrane that bind cholesterol, control vital membrane properties, participate in signal transmission and serve as adhesion molecules in recognition processes relevant to immunity and infection. While the pathway of sphingolipid biosynthesis has been well chara… Show more
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