Complex single step skull reconstruction in Gorham’s disease - a technical report and review of the literature

Abstract

BackgroundGorham’s disease is a rare osteolytic disorder characterized by progressive resorption of bone and replacement of osseous matrix by a proliferative non-neoplastic vascular or lymphatic tissue. A standardized treatment protocol has not yet been defined due to the unpredictable natural history of the disease and variable clinical presentations. No single treatment has proven to be superior in arresting the course of the disease. Trials have included surgery, radiation and medical therapies using drugs such as calcium salts, vitamin D supplements and hormones. We report on our advantageous experience in the management of this osteolyic disorder in a case when it affected only the skull vault. A brief review of pertinent literature about Gorham’s disease with skull involvement is provided.Case presentationA 25-year-old Caucasian male presented with a skull depression over the left fronto-temporal region. He noticed progressive enlargement of the skull defect associated with local pain and mild headache. Physical examination revealed a tender palpable depression of the fronto-temporal convexity. Conventional X-ray of the skull showed widespread loss of bone substance. Subsequent CT scans showed features of patchy erosions indicative of an underlying osteolysis. MRI also revealed marginal enhancement at the site of the defect. The patient was in need of a pathological diagnosis as well as complex reconstruction of the afflicted area. A density graded CT scan was done to determine the variable degrees of osteolysis and a custom made allograft was designed for cranioplasty preoperatively to allow for a single step excisional craniectomy with synchronous skull repair. Gorham’s disease was diagnosed based on histopathological examination. No neurological deficit or wound complications were reported postoperatively. Over a two-year follow up period, the patient had no evidence of local recurrence or other systemic involvement.ConclusionsA single step excisional craniectomy and cranioplasty can be an effective treatment for patients with Gorham’s disease affecting the skull vault only. Preoperative planning by a density graded CT aids to design a synthetic bone flap and is beneficial in skull reconstruction. Systemic involvement is variable in this patient’s population.

Massive Axial and Appendicular Skeletal Deformities in Connection with Gorham-Stout Syndrome

“…Because of the rarity of GSD, the diagnosis of this syndrome is challenging for clinicians and requires the exclusion of other osteolysis-associated disorders such as inflammatory, metabolic, infectious (e.g., osteomyelitis), malignant neoplasm (e.g., squamous cell carcinoma), other hereditary, traumatic, and endocrine diseases. Extensive metastatic bone disease due to breast cancer, and osteosarcoma as well as aneurysmal bone cyst, is some of the conditions that resemble vanishing bone disease and can be distinguished by a biopsy [20,21]. Moreover, there is no definitive treatment to treat this disorder has been established yet and most patients have been treated with surgery and or radiation therapy [22,23].…”

“…Moreover, there is no definitive treatment to treat this disorder has been established yet and most patients have been treated with surgery and or radiation therapy [22,23]. Other conventional therapies have also been tried using drugs such as interferon-α2b, which was found to effective chylothorax treatment [23] in addition to RANK-ligand inhibitor (Denosumab), anti-VEGF-A antibody (Bevacizumab), steroids, vitamin D, and calcitonin to control of progressive osteolytic activity and to slow mandibular resorption [21,24,25,26].…”