“…Because of the rarity of GSD, the diagnosis of this syndrome is challenging for clinicians and requires the exclusion of other osteolysis-associated disorders such as inflammatory, metabolic, infectious (e.g., osteomyelitis), malignant neoplasm (e.g., squamous cell carcinoma), other hereditary, traumatic, and endocrine diseases. Extensive metastatic bone disease due to breast cancer, and osteosarcoma as well as aneurysmal bone cyst, is some of the conditions that resemble vanishing bone disease and can be distinguished by a biopsy [20,21]. Moreover, there is no definitive treatment to treat this disorder has been established yet and most patients have been treated with surgery and or radiation therapy [22,23].…”