Complex role of peroxisome proliferator activator receptors (PPARs) in nociception

Giniatullin, Rashid; Bart, Geneviève; Tavi, Pasi

doi:10.1016/j.sjpain.2015.08.006

Cited by 2 publications

(2 citation statements)

References 15 publications

(19 reference statements)

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“…Recently, activation of various transcriptional factors was linked also with fast non-genomic effects within the nociceptive system30. This is likely applicable also to signalling initiated by the vitamin D25.…”

Section: Discussionmentioning

confidence: 93%

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Virtanen

Giniatullin

Mäntyselkä

et al. 2017

Sci Rep

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Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42–60 years in 1984–1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8–136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men.

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Section: Discussionmentioning

confidence: 93%

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Virtanen

Giniatullin

Mäntyselkä

et al. 2017

Sci Rep

Self Cite

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“…39 In the peripheral sensory neurons, the activated PPARα diminishes pain by desensitizing the TRPV1 ion channels. 40 Development of analgesics involving these receptors seem to be the safer anti-nociceptive treatment strategies compared to the conventional opiates and NSAIDS. Hence, in this study, we have investigated the role of CB1, CB2, PPARα and TRPV1 receptors in Viphyllin-mediated analgesic effects.…”

mentioning

confidence: 99%

ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

Venkatakrishna¹,

K²,

HV³

et al. 2022

JPR

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Plant-based natural products as anti-nociceptors have enormous potential as safer alternatives to conventional opiates and NSAIDS. Piper nigrum (black pepper) is one of the major culinary spices with medicinal attributes. Methods: In the present study, the antinociceptive activity of a standardized black pepper seed extract (Viphyllin) containing not less than 30% β-caryophyllene (BCP) was evaluated using pain models in mice, namely acetic acid-induced writhing test, formalin-induced paw licking test, hot plate test and tail flick test. Further, the antagonists SR141716A (0.1 mg/kg i.p.), AM630 (5 mg/kg i.p.), capsazepine (0.1 mg/kg body weight i.p.), and GW6471 (1 mg/kg i.p.) were used to evaluate the involvement of cannabinoid receptors CB1 and CB2, TRPV1 ion channel and PPARα receptor, respectively. Molecular docking (AutoDock 4.2) was used to study the interaction of BCP with the agonist-binding sites of the selected pain receptors. Results: Viphyllin at 10 mg, 25 mg and 50 mg/kg (i.p.) significantly inhibited the writhings in mice as compared to untreated control group (p < 0.001). Further, Viphyllin at 50 mg/kg showed strong antinociceptive effect in formalin-induced paw licking test (p < 0.05). Pretreatment of mice with AM630 significantly reversed the antinociceptive activity of Viphyllin in both early and late phases of formalin test (p < 0.05). Administration of Viphyllin markedly increased the latency time of mice in hot plate test (p < 0.001). Further, Viphyllin markedly increased the latency time of tail flick compared to control group from 30 min to 90 min after treatment. AM630, Capsazepine, and GW6471 abolished the analgesic effect of Viphyllin. These findings clearly suggest the involvement of CB2 receptor, TRPV1 ion channel and PPARα receptor activation in Viphyllin-mediated antinociceptive activity. Docking score predictions further supported the possible involvement of BCP in the antinociceptive mechanism of Viphyllin. Conclusion:In conclusion, Viphyllin could be a natural pain-relieving agent involving safer pain signaling mechanisms, unlike conventional opiates and NSAIDs.

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Complex role of peroxisome proliferator activator receptors (PPARs) in nociception

Cited by 2 publications

References 15 publications

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men

ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

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