Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress

Serban, Andreea Iren; Stanca, Loredana; Sima, Cornelia; Staicu, Angela; Zarnescu, Otilia; Dinischiotu, Anca

doi:10.1016/j.cbi.2015.06.015

Cited by 6 publications

(8 citation statements)

References 77 publications

(83 reference statements)

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“…The reason could be that the ultradispersive nature of oxide particles may lead to their accumulation in the tissues of fish. It has previously been shown in several studies [24,27,30]. Such a fact was also observed in our experiments, especially in the first weeks, which is well seen on the example of silicon (Fig.…”

Section: The Catalasesupporting

confidence: 92%

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ASSESSMENT OF GENERAL TOXICITY AND PROOXIDANT EFFECTS OF CeO2 AND SiO2 NANOPARTICLES ON Danio rerio

Miroshnikova¹,

Kosyan²,

Arizhanov³

et al. 2016

S-h. biol.

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A b s t r a c tA diversified use of nanomaterials leads to their accumulation in the environment and involvement into remediation. In water biocoenosis, nanomaterials influence fishes. Lipid peroxidation (LPO) in aquatic bioindicators is considered the parameters generally used to assess an impact of man-caused water pollution. It should be taken into account that the level of LPO products can be due not only to anthropogenic pollution, but also to the presence of peroxide substrates in fish tissues. We firstly showed the effect of silica and cerium nanoparticles in water environment with direct assay of the enzyme activity of the bioindiator used. Our purpose was to evaluate the prooxidant effects of CeO 2 (15.8 nm) and SiO 2 (40.9 nm) nanoparticles (NPs) on the Danio rerio model, to study LPO as influenced by the NPs doses, and to find out if there are any adaptive mechanisms in Danio rerio to withstand the NPs in the habitat. Complete death of the test objects occurred on days 80 and 84 when CeO 2 NPs used. The first signs of the CeO 2 NPs toxic effect at a dose of 10 mg/dm 3 in the feed appeared on day 45, on day 56 the test-organism number was 33 % lower, and on day 65 a more than 54 % decline occurred. SiO 2 NPs led to 33 % reduced survival. The presence of the nanoparticles in the habitat depressed the antioxidant system of Danio rerio but the signs of adaptation were manifested by the end of week 2, and a significant increase in catalase (CAT) and superoxide dismutase (SOD) activity proceeded by the end of the test. At 10 and 100 mg/dm 3 of CeO 2 NPs the malonic dialdehyde (MDA) level decreased by 11.0 % and 61.0 %, respectively. For SiO 2 NPs the changes were similar with the MDA level decrease of 50.0 and 41.5 % at 10 and 100 mg/dm 3 dosage, respectively. SOD activity when influenced by CeO 2 NPs (10 mg/dm 3 and 100 mg/dm 3 ) decreased by 75 and 69 %, respectively, and for SiO 2 NPs the indexes were 50 and 26 % lower as compared to control. Similar changes were characteristic of CAT activity. Thus, the investigated nanoparticles possess sufficient toxic properties that necessitates their further study.

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Section: The Catalasesupporting

confidence: 92%

“…In a model of Carassius auratus gibelio (crucian carp), the ability of the Si/SiO 2 nanoparticles to induce an inflammatory response was demonstrated [23]. Similar results were also obtained in other test objects [24][25][26].…”

supporting

confidence: 72%

ASSESSMENT OF GENERAL TOXICITY AND PROOXIDANT EFFECTS OF CeO2 AND SiO2 NANOPARTICLES ON Danio rerio

Miroshnikova¹,

Kosyan²,

Arizhanov³

et al. 2016

S-h. biol.

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“…Meanwhile, the QDs caused an elevation in the ratio of GSH/oxidised glutathione at12 weeks, but significantly reduced at 16 weeks in QD705‐treated animals, which reflected the oxidative stress (Lin et al, ). Other studies have also proven that QDs can lead to a significant increase in the levels of the ROS or ·OH, and changes in the concentration or activity of glutathione peroxidase, CAT and SOD (Serban et al, ; S. Wang et al, ; Y. Yang, T. Zhao et al, ; Yang et al, ; Zhang et al, ).…”

Section: Toxic Effects Of Quantum Dotsmentioning

confidence: 99%

“…However, the levels of IL‐6, lactate dehydrogenase and NADPH oxidase were significantly increased in the liver after 7 days, which indicated that QDs could cause damage to liver cells and induced an inflammatory response, but did not clarify which cells were damaged (Haque et al, ). In addition, studies have shown that Si QDs can induce the cyclooxygenase 2 activity increased by 100%, 165% and 153% after exposed to Si QDs for one, two and three weeks compared to controls (Serban et al, ). Cyclooxygenase‐2 is induced by proinflammatory cytokines, growth factors and tumor promoters, is always present at the site of inflammation and is considered as an indicator of immune response (El Sayed et al, ).…”

Section: Toxic Effects Of Quantum Dotsmentioning

confidence: 99%

“…Cyclooxygenase‐2 is induced by proinflammatory cytokines, growth factors and tumor promoters, is always present at the site of inflammation and is considered as an indicator of immune response (El Sayed et al, ). Simultaneously, Si QDs can lead to a two‐ to threefold increase in the expression levels of matrix metalloproteinases (MMP) 2 and MMP‐9 genes and a 141% increase in the activity of MMP‐2 and MMP‐9 (Serban et al, ). Changes in the levels of MMPs can be considered as an indicator of inflammation (Castillo‐Briceno, Arizcun‐Arizcun, Meseguer, Mulero, & Garcia‐Ayala, ).…”

Section: Toxic Effects Of Quantum Dotsmentioning

confidence: 99%

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Review of toxicological effect of quantum dots on the liver

Tang

Zhang

2018

J of Applied Toxicology

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In recent years, quantum dots (QDs) have potential applications in technology, research and medicine. The small particle size is coupled to their unique chemical and physical properties and their excellent fluorescence characteristics. A growing number of studies have shown that QDs are distributed to secondary organs through multiple pathways, while the liver is the main reservoir of QDs. Here, we review current liver toxicity studies of QDs in vivo and in vitro. Mechanisms of hepatotoxicity are discussed and the problem of extrapolating knowledge gained from cell-based studies into animal studies is highlighted. In this context, there still exists significant discrepancies between in vitro and in vivo results, and the specific toxicity mechanism remains unclear. The hepatotoxicities of QDs are the need for a unifying protocol for reliable and realistic toxicity reports.

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