Complex Renal Traits

Fung, Maple M.; O’Connor, Daniel T.

doi:10.1681/asn.2009040395

Cited by 1 publication

(1 citation statement)

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“…Surgery-associated acute kidney injury (AKI) is a common and serious complication after cardiac surgery, which increases the risk of mortality, morbidity as well as length of the hospital stay. [1][2][3][4][5][6] The incidence of AKI associated with cardiac surgery may reach 50%, 3,7-10 depending on the definition. The diagnosis of AKI is suggested by the Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group as an increase in serum creatinine (SCr) and/or a decrease in urine production.…”

Section: Introductionmentioning

confidence: 99%

<p>HO-1 concentrations 24 hours after cardiac surgery are associated with the incidence of acute kidney injury: a prospective cohort study</p>

Magyar

Wagner

Thomas

et al. 2019

IJNRD

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BackgroundAcute kidney injury (AKI) is a serious complication after cardiac surgery that is associated with increased mortality and morbidity. Heme oxygenase-1 (HO-1) is an enzyme synthesized in renal tubular cells as one of the most intense responses to oxidant stress linked with protective, anti-inflammatory properties. Yet, it is unknown if serum HO-1 induction following cardiac surgical procedure involving cardiopulmonary bypass (CPB) is associated with incidence and severity of AKI.Patients and methodsIn the present study, we used data from a prospective cohort study of 150 adult cardiac surgical patients. HO-1 measurements were performed before, immediately after and 24 hours post-CPB. In univariate and multivariate analyses, the association between HO-1 and AKI was investigated.ResultsAKI with an incidence of 23.3% (35 patients) was not associated with an early elevation of HO-1 after CPB in all patients (P=0.88), whereas patients suffering from AKI developed a second burst of HO-1 24 hours after CBP. In patients without AKI, the HO-1 concentrations dropped to baseline values (P=0.031). Furthermore, early HO-1 induction was associated with CPB time (P=0.046), while the ones 24 hours later lost this association (P=0.219).ConclusionThe association of the second HO-1 burst 24 hours after CBP might help to distinguish between the causality of AKI in patients undergoing CBP, thus helping to adapt patient stratification and management.

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