Complex regional pain syndrome type 1 predictors — Epidemiological perspective from a national database analysis

Elsharydah, Ahmad; Loo, Nathaniel; Minhajuddin, Abu; Kandil, Enas

doi:10.1016/j.jclinane.2017.03.027

Cited by 39 publications

(31 citation statements)

References 9 publications

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“…In a more recent study from the US, the diagnosis of CRPS emerged at a rate of 70 per 100,000 hospital discharges over a 4-year period. 10 The most likely causes for those variations ( Table 3) are differences in the type of source data and the methods of case ascertainment. Indeed, in a literature search aiming to assess the use of the IASP criteria, only 38% of the publications mentioned the application of the criteria and only 15% of the referenced publications satisfied them.…”

Section: Epidemiologymentioning

confidence: 99%

“…Various comorbidities also seem to affect the occurrence of CRPS, including depression, headache and drug abuse. 10 In a prospective study by Bean et al investigating how psychological factors influence the recovery of patients with CRPS, it was concluded that anxiety, pain-related fear and disability have a negative effect, thus implicating psychological parameters for poorer recovery. 12 In contrast, some diseases do not appear to associate with the syndrome, such as diabetes, anemia, obesity and hypothyroidism.…”

Section: Epidemiologymentioning

confidence: 99%

“…12 In contrast, some diseases do not appear to associate with the syndrome, such as diabetes, anemia, obesity and hypothyroidism. 10…”

Section: Epidemiologymentioning

confidence: 99%

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Complex Regional Pain Syndrome: An update

Misidou¹,

Papagoras²

2019

MJR

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Complex regional pain syndrome (CRPS) is a perplexing painful syndrome of the extremities usually following a harmful event. It is distinguished in two types, mainly depending on the presence of nerve injury. Although its prevalence may vary depending on social and ethnic factors, middle-aged women seem to suffer most often and the upper limb is the most commonly affected extremity. Apart from pain, which is the dominating feature, the clinical picture unfolds across several domains: sensory, motor, autonomic and trophic. This syndrome develops in two phases, the acute (warm) phase, with the classic symptoms of inflammation, and the chronic (cold) phase, often characterized by trophic changes of the soft tissues and even bones. Although the syndrome has been studied for over two decades, no imaging or laboratory test has been established for the diagnosis and recently proposed diagnostic criteria have not yet been validated and are only occasionally applied. Its pathophysiology is still quite obscure, although the most likely mechanisms involve the classic and neurogenic paths of inflammation mediated by cytokines and neuropeptides, intertwined with changes of the autonomic and central nervous system, psychological mechanisms and, perhaps, autoimmunity. Although plenty of treatment modalities have been tried, none has been proven unequivocally efficacious. Apart from information and education, which should be offered to all patients, the most effective pharmacological treatments seem to be bisphosphonates, glucocorticoids and vasoactive mediators, while physical therapy and rehabilitation therapy also make part of the treatment.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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Complex Regional Pain Syndrome: An update

Misidou¹,

Papagoras²

2019

MJR

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“…Among population and cohort studies, evidence existed on the impact of sociodemographic characteristics, with females [26][27][28][29][30][31][32][33] and older people [6,27,28,31,32,34] reporting higher pain rates or severity. Also, people with lower education level and those unemployed had higher pain rates [35,36], but contrasting results were found with reference to socioeconomic position: in fact, Chen and colleagues found that people with a lower socioeconomic class had a more severe trajectory with regard to low back pain severity and persistence [37], whereas Elsharydah and colleagues found that higher median household income was associated with higher rate of complex regional pain syndrome type 1 [30]. Evidence was also found on the impact of some mental health problems and symptoms on pain rates and severity, including sleep problems [6,27,34,38,39], depressed mood or anxiety [26, 28-30, 34, 35, 39, 40], cognitive complaints [34] and fatigue or lack of energy [38].…”

Section: Introductionmentioning

confidence: 99%

“…Evidence was also found on the impact of some mental health problems and symptoms on pain rates and severity, including sleep problems [6,27,34,38,39], depressed mood or anxiety [26, 28-30, 34, 35, 39, 40], cognitive complaints [34] and fatigue or lack of energy [38]. Other health status variables that were found to be associated with higher pain rates and severity included the presence of comorbidities and multimorbidity status [6,26,30,35,39,41] and, among single heath conditions, diabetes and stroke [30,42,43]: of course, presence of conditions whose cardinal symptom is pain, such as headaches, musculoskeletal conditions or angina, is clearly acknowledged to impact on pain. Finally, a set of risk and protective lifestyle factors were also identified.…”

Section: Introductionmentioning

confidence: 99%

Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database

et al. 2020

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Background: Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people, and with increasing trends in general populations. Different risk factors for pain have been identified, but generally from studies with limited samples and a limited number of candidate predictors. The aim of this study is to evaluate the predictors of pain from a large set of variables and respondents. Methods: We used part of the harmonized dataset of ATHLOS project, selecting studies and waves with a longitudinal course, and in which pain was absent at baseline and with no missing at follow-up. Predictors were selected based on missing distribution and univariable association with pain, and were selected from the following domains: Sociodemographic and economic characteristics, Lifestyle and health behaviours, Health status and functional limitations, Diseases, Physical measures, Cognition, personality and other psychological measures, and Social environment. Hierarchical logistic regression models were then applied to identify significant predictors. Results: A total of 13,545 subjects were included of whom 5348 (39.5%) developed pain between baseline and the average 5.2 years' follow-up. Baseline risk factors for pain were female gender (OR 1.34), engaging in vigorous exercise (OR 2.51), being obese (OR 1.36) and suffering from the loss of a close person (OR 1.88) whereas follow-up risk factors were low energy levels/fatigue (1.93), difficulties with walking (1.69), self-rated health referred as poor (OR 2.20) or average to moderate (OR 1.57) and presence of sleep problems (1.80).

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Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II

Smart

Ferraro

Wand

et al. 2022

Cochrane Database of Systematic Reviews

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BackgroundComplex regional pain syndrome (CRPS) is a painful and disabling condition that usually manifests in response to trauma or surgery. When it occurs, it is associated with significant pain and disability. It is thought to arise and persist as a consequence of a maladaptive pro-inflammatory response and disturbances in sympathetically-mediated vasomotor control, together with maladaptive peripheral and central neuronal plasticity. CRPS can be classified into two types: type I (CRPS I) in which a specific nerve lesion has not been identified, and type II (CRPS II) where there is an identifiable nerve lesion. Guidelines recommend the inclusion of a variety of physiotherapy interventions as part of the multimodal treatment of people with CRPS, although their effectiveness is not known.Physiotherapy for pain and disability in adults with complex regional pain syndrome... 26-Feb-2016 Review Manager 5.2 4 associated with CRPS I after traumatic events or surgery or a stroke. From the limited evidence available it appears that some types of electrotherapy, such as ultrasound and pulsed electromagnetic field therapy, as well as a type of massage therapy known as manual lymphatic drainage, are not effective. Most studies did not report on adverse events and so we do not know if these treatments have any harmful side-effects.On the whole, because of the limited number and low quality of available trials for the various physiotherapy treatments, we cannot be sure if any of the physiotherapy treatments we evaluated are effective for treating the pain and disability of CRPS I in adults. It is possible that some treatments, such as GMI or mirror therapy, might be effective. Further high quality clinical trials of physiotherapy are needed in order to find out if any of the different types of physiotherapy treatment are effective at improving pain and disability in people with CRPS.Physiotherapy for pain and disability in adults with complex regional pain syndrome... 26-Feb-2016Review Manager 5.2 9'Risk of bias' summary: review authors' judgements about each 'Risk of bias' item for each included trial. Sources of support Internal sourcesNo sources of support provided

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Complex regional pain syndrome type 1 predictors — Epidemiological perspective from a national database analysis

Cited by 39 publications

References 9 publications

Complex Regional Pain Syndrome: An update

Complex Regional Pain Syndrome: An update

Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database

Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II

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