Complex regional pain syndrome

Stanton‐Hicks, Michael

doi:10.1002/9781119701170.ch37

Cited by 3 publications

(5 citation statements)

References 96 publications

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“…As the limb perspires, the indicator changes color. It has been demonstrated that quantitative sweat testing corresponds with CRPS clinical symptoms [26]. Two useful procedures that assess the sweat productivity of the afflicted and unaffected limbs are the quantitative sudomotor axon reflex test and the resting sweat output test [27].…”

Section: Resultsmentioning

confidence: 99%

“…The test for resting sweat output is used to measure the amount of perspiration produced by the limbs when they are at rest, as its name suggests. A provocative test called the measurements of the quantified sudomotor axon reflex the amount of sweat produced while encountering a cholinergic iontophoresis challenge, such as acetylcholine or methacholine [26]. Radiographic Testing: As early as two weeks following the beginning of CRPS, plain radiographs might reveal patchy osteoporosis [25].…”

Section: Resultsmentioning

confidence: 99%

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Physical Medicine and Rehabilitation for Complex Regional Pain Syndromes

Youssef Elias,

Mohammed Almoulem

2023

SMHJ

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A common clinical constellation of pain, sensory, autonomic, motor, or trophic symptoms that can no longer be attributed to the initial trauma characterizes Complex Regional Pain Syndrome (CRPS). These signs and symptoms are not localized to the areas of innervation. Most of the diagnosis is clinical. Following that, mobility difficulties, fluctuating skin temperature, sensory loss and changes in body perception are the prominent symptoms. In acute phases, pharmaceutical treatment may be very beneficial. Empirically, common anti-neuropathic pain medications can be suggested. Physical and occupational therapy, as well as behavioral therapy, are crucial parts of the treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Physical Medicine and Rehabilitation for Complex Regional Pain Syndromes

Youssef Elias,

Mohammed Almoulem

2023

SMHJ

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“…Complex regional pain syndrome (CRPS) is a rare neuropathic pain disorder causing extreme discomfort, muscle weakness, limb edema, and hyperhidrosis, with potential risk factors including fracture, surgery, stroke, and spinal cord damage [ 1 ]. Underlying causes include a variety of processes, including sensory, motor, inflammatory, immune/auto-immune, autonomic, and genetic impacts [ 2 ]. The main characteristics of CRPS include spontaneous pain, hyperalgesia, allodynia, and abnormal vasomotor and sudomotor activity [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Complex Regional Pain Syndrome in a Non-traumatic Case: A Case Report

Abuzied,

Jaber,

Hafiz

et al. 2024

Cureus

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Complex regional pain syndrome (CRPS) is an uncommon neuropathic pain illness characterized by extreme discomfort, muscular weakness, limb edema, and hyperhidrosis. Fracture, surgery, stroke, and spinal cord damage are all potential risk factors. This case report study provides a detailed description of no-traumatic CRPS, a complex pain illness characterized by sensory, vasomotor, sudomotor, motor, trophic, and edematous changes and persistent discomfort. We reported a case of a 39-year-old male with a seven-year history of severe right shoulder-hand pain. He presented with recurrent hand and shoulder pain characterized by burning sensations and weakness, despite not having experienced this before, and he denied any history of trauma or fracture. Surgical procedure and pharmaceutical therapy were provided, but there was no outcome, as evidenced by the patient's clinical condition and the medical records. Despite extensive investigation, no imaging or laboratory tests have been developed for diagnosis, necessitating further research for a comprehensive understanding and diagnosis.

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“…Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain and is characterized by intractable pain, multiple system dysfunction, and motor and autonomic dysfunction [ 1 ]. CRPS can be classified into two subtypes based on the presence (type II) or absence (type I) of direct nerve injuries [ 2 , 3 , 4 ]. There are several medical treatments available for CRPS, such as prophylactic vitamin C, narcotics, anticonvulsants, such as gabapentin or pregabalin, tricyclic antidepressants, and ketamine.…”

Section: Introductionmentioning

confidence: 99%

“…However, in many cases these medications do not often have high efficacy. These therapeutic limitations are partly attributed to the insufficient evidence on the pathogenesis of CRPS [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srIκBs) in Chronic Post-Ischemia Pain (CPIP) Models

Chae

Park

Ahn³

et al. 2023

Pharmaceutics

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Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain that causes significant impairment of daily activities and functioning. Nuclear factor kappa B (NFκB) is thought to play an important role in the mechanism of CRPS. Recently, exosomes loaded with super-repressor inhibitory kappa B (Exo-srIκB, IκB; inhibitor of NFκB) have been shown to have potential anti-inflammatory effects in various inflammatory disease models. We investigated the therapeutic effect of Exo-srIκB on a rodent model with chronic post-ischemia pain (CPIP), a representative animal model of Type I CRPS. After intraperitoneal injection of a vehicle, Exo-srIκB, and pregabalin, the paw withdrawal threshold (PWT) was evaluated up to 48 h. Administration of Exo-srIκB increased PWT compared to the vehicle and pregabalin, and the relative densities of p-IκB and IκB showed significant changes compared to the vehicle 24 h after Exo-srIκB injection. The levels of several cytokines and chemokines were reduced by the administration of Exo-srIκB in mice with CPIP. In conclusion, our results showed more specifically the role of NFκB in the pathogenesis of CRPS and provided a theoretical background for novel treatment options for CRPS.

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Complex regional pain syndrome

Cited by 3 publications

References 96 publications

Physical Medicine and Rehabilitation for Complex Regional Pain Syndromes

Physical Medicine and Rehabilitation for Complex Regional Pain Syndromes

Complex Regional Pain Syndrome in a Non-traumatic Case: A Case Report

The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srIκBs) in Chronic Post-Ischemia Pain (CPIP) Models

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