Complex permittivities of breast tumor tissues obtained from cancer surgeries

Abstract

The variability in measurements of complex permittivities of tumor tissues between multiple samples could be attributed to the volume fraction of cancer cells in the excised tumor tissue. By the use of a digital photomicrograph image and hematoxylin-eosin staining, it was found that the malignant tumor tissue was not fully occupied by the cancer cells, but the cells were distributed locally in the stroma cells depending on the growth of cancer. The results showed that the volume fraction of cancer cells in the tumor tissue had a correlation to the measured conductivity and dielectric constant in the frequency range from 1 GHz to 6 GHz. It introduces a method to understand and gauge variability in measurements between different tumors.

MARIA M4: clinical evaluation of a prototype ultrawideband radar scanner for breast cancer detection

“…Glandular tissue is distributed whereas malignant and cystic tissue tends at diagnosis to be discrete and, therefore, much easier to image. Similar results were obtained using completely different measurement techniques by Sugitani et al 32 showing overlap of tissue values.…”

“…The various tissue types found in the breast have clearly identifiable dielectric constants in the microwave frequency range, 27,32 which result in incident signals being reflected and attenuated differently at each interface between the tissue types. It is these signals the system collects and accumulates at each point in the estimated tissue space.…”

Investigation of the effect of dehydration on tissue dielectric properties in ex vivo measurements

“…In addition to healthy biological tissue, the dielectric properties of a wide range of cancerous tissue has also been dielectrically characterized. For example, a number of studies, (Chaudhary et al 1984, Surowiec et al 1988, Joines et al 1994, O'Rourke et al 2007, Sugitani et al 2014 characterized the dielectric properties of cancerous tissues that are being used in the development of medical diagnostic and therapeutic applications.…”

Modeling of the dielectric properties of biological tissues within the histology region

“…In order to attribute dielectric properties to heterogeneous tissues, researchers may conduct histological analysis [9]- [11]. Histological analysis provides information on what tissue types are present in a sample, and in what distribution or layout.…”