Complex outflow anatomy in left lateral lobe graft and modified venous reconstruction in pediatric living donor liver transplantation

Benetatos, Nikolaos; Scalera, Irene; Isaac, John; Mirza, Darius F.; Muiesan, Paolo

doi:10.1111/tri.12388

Cited by 3 publications

(3 citation statements)

References 13 publications

(41 reference statements)

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“…5,9 In the event of metastatic disease limited to the liver, transplantation has been described as a possible strategy for first-line or second-line treatment after the primary tumor has been resected. 14,19,20 The only reported case of a child with PB receiving a liver transplant after a hepatic recurrence subsequently had a second relapse in the lungs, however. 14 Our review suggests that long-term survival is still possible for patients with relapsed PB, and those with local recurrences seem to have a substantial second chance of cure.…”

Section: Discussionmentioning

confidence: 99%

“…In the event of metastatic disease limited to the liver, transplantation has been described as a possible strategy for first-line or second-line treatment after the primary tumor has been resected 14,19,20. The only reported case of a child with PB receiving a liver transplant after a hepatic recurrence subsequently had a second relapse in the lungs, however 14…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review

Reggiani¹,

Affinita²,

Dall’Igna

et al. 2020

Journal of Pediatric Hematology/Oncology

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Pancreatoblastoma (PB) is a tumor typically seen in childhood. Despite its rarity, there are some internationally agreed recommendations for its first-line treatment, but very little is known about the management of relapse. We reviewed the literature on the treatment and outcome of children with progressing/recurrent PB, and the role of high-dose chemotherapy (HD-CT) or liver transplantation in difficult cases. A first analysis concerned 15 patients: liver metastases were the most frequent cause of first-line treatment failure. Eight patients underwent surgery, only 3 were irradiated. Various second-line chemotherapy regimens were adopted, with evidence of response in 8 children. The most often-used combinations included etoposide, cyclophosphamide/ifosfamide, and cisplatin/carboplatin. Overall, 7 patients are alive with a median follow-up of 24 months (range, 3 to 88 mo). In a separate analysis, considering patients in first-line or second-line treatment, we found 5 of 6 patients alive after HD-CT and 3 of 3 after liver transplantation. Our review shows that the outcome for patients with recurrent PB is not always dismal, especially when surgery is possible. Different chemotherapy combinations can be used, and HD-CT or liver transplantation may be considered in selected cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review

Reggiani¹,

Affinita²,

Dall’Igna

et al. 2020

Journal of Pediatric Hematology/Oncology

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show abstract

“…A large longitudinal opening in the vena cava is used in other transplant groups for graft implantation . The described alternative reconstruction involves situations where there is a complex left HV anatomy, such as described by Benetatos et al : two major vein branches (left HV and superficial left HV) and two accessories (accessory left HV) converging at the graft's cutline. A U‐shaped vein patch was fashioned and the authors were able to include all the veins in one wide orifice and obtained sufficient length for an end‐to‐side anastomosis to the IVC.…”

Section: Discussionmentioning

confidence: 99%

Alternatives for vascular reconstruction in pediatric living donor liver transplantation

Neto

Fonseca

Cândido

et al. 2016

Pediatric Transplantation

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Many publications discuss the various strategies for vascular reconstruction (VR) in pediatric LDLT. Having knowledge of alternative techniques is helpful in planning transplants. This article presents three case reports that illustrate some of the alternative techniques for HV, PV, and HA reconstruction in pediatric LDLT. It also reviews the available alternative strategies reported for VR in pediatric LDLT. In the first case, a 13-month-old girl presented a PRETEXT III HB with invasion of the retrohepatic vena cava. An LLS graft HV was anastomosed to a DD iliac vein graft and subsequently implanted in a "standard" fashion in the recipient. In the second case, a 44-month-old boy presented with multifocal HB and portomesenteric thrombosis and the portal inflow was done through a renoportal anastomosis. In the third case, a 22-month-old child with a failed Kasai procedure had extensive HA thrombosis. The HA reconstruction was performed with an interposition of the recipient's IMV graft. The use of alternative techniques for VR in pediatric LDLT is paramount to the success of such a complex procedure. Imaging studies can help transplant surgeons outline surgical strategies and define the best technique to be used in each case.

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Pancreatoblastoma: A rare indication for liver transplantation in children

Mercadal-Hally

Vaidya

Vilca‐Melendez

et al. 2020

Hepatobiliary & Pancreatic Diseases International

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Complex outflow anatomy in left lateral lobe graft and modified venous reconstruction in pediatric living donor liver transplantation

Abstract: Keywords graft outflow obstruction, hepatic vein anatomy of the left lateral liver, left hepatic vein, segmental pediatric liver transplantation, venous patch.

Cited by 3 publications

References 13 publications

Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review

Treatment Strategies for Children With Relapsed Pancreatoblastoma: A Literature Review

Alternatives for vascular reconstruction in pediatric living donor liver transplantation

Pancreatoblastoma: A rare indication for liver transplantation in children

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