2008
DOI: 10.1590/s1415-47572008000400001
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Complex networks: the key to systems biology

Abstract: Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic complexity and systemic organization of life, complex networks provide a specially promising framework for systems biology investigation. The current article is an up-to-date review of the major developments related to the application of complex networks in biology, with special attention focused … Show more

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Cited by 77 publications
(48 citation statements)
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References 81 publications
(98 reference statements)
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“…Only the alignments passing a threshold of 70% identity for each PSSM were considered as significant matches. We used concepts of graph theory and complex networks [39]. …”
Section: Methodsmentioning
confidence: 99%
“…Only the alignments passing a threshold of 70% identity for each PSSM were considered as significant matches. We used concepts of graph theory and complex networks [39]. …”
Section: Methodsmentioning
confidence: 99%
“…3 In the present work, we study this system for parameter and state estimation along with structure identification with a 5-variable S-system in-lieu of the model Eq. (18) .…”
Section: Circadian Oscillations Of Period Protein In Drosophilamentioning
confidence: 99%
“…Complex behavior observed in biological systems are manifested through interaction networks of biomolecules in the form of gene regulatory networks, metabolic pathways and signaling cascades [1][2][3] . The presence of highly nonlinear interactions makes mathematical modeling of such systems a difficult task.…”
Section: Introductionmentioning
confidence: 99%
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“…Application of the CNT has been increasing since the twentieth century, with extensive studies in social sciences [6], computer science [7], transport [8], and biological sciences [9]. In particular, the CNT has been increasingly accepted in ecological studies over the last 17 years, and its development is fast and consistent [10], being a robust tool for ecosystem stability analysis, with possible applications in biodiversity and conservation [11], and as an indicator of the ecosystem health [1].…”
Section: Introductionmentioning
confidence: 99%