Complex Molecule Synthesis, a Personal View

Hoffmann, Reinhard W.

doi:10.1002/ijch.201700086

Cited by 6 publications

(1 citation statement)

References 33 publications

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“…Over almost two centuries, starting with Friedrich Wöhler, , researchers have developed synthetic methods to prepare various natural products and derivatives thereof as well as completely new molecules . Consequently, organic synthesis has become a highly powerful art providing versatile protocols to prepare molecules of and for our life. − Thus organic synthesis provides access to chemical compounds that cover our daily needs with respect to virtually every aspect of modern life, including clothing, hygiene, nutrition, transport, housing, and health.…”

Section: Need For a Broad Toolbox Of (Chiral) Catalysts For Organic S...mentioning

confidence: 99%

Power of Biocatalysis for Organic Synthesis

2021

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Biocatalysis, using defined enzymes for organic transformations, has become a common tool in organic synthesis, which is also frequently applied in industry. The generally high activity and outstanding stereo-, regio-, and chemoselectivity observed in many biotransformations are the result of a precise control of the reaction in the active site of the biocatalyst. This control is achieved by exact positioning of the reagents relative to each other in a fine-tuned 3D environment, by specific activating interactions between reagents and the protein, and by subtle movements of the catalyst. Enzyme engineering enables one to adapt the catalyst to the desired reaction and process. A well-filled biocatalytic toolbox is ready to be used for various reactions. Providing nonnatural reagents and conditions and evolving biocatalysts enables one to play with the myriad of options for creating novel transformations and thereby opening new, short pathways to desired target molecules. Combining several biocatalysts in one pot to perform several reactions concurrently increases the efficiency of biocatalysis even further.

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Section: Need For a Broad Toolbox Of (Chiral) Catalysts For Organic S...mentioning

confidence: 99%

Power of Biocatalysis for Organic Synthesis

2021

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Manganese Catalyzed Acceptorless Dehydrogenative Coupling Reactions

Waiba

Maji

2020

ChemCatChem

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Acceptorless dehydrogenative coupling (ADC) has emerged as a powerful tool in the chemists’ arsenal for the construction of various carbon‐carbon and carbon‐heteroatom bonds. These protocols are highly atom economical and environmentally benign as they do not require pre‐functionalized starting material and produce only dihydrogen (and water) as the by‐product. This technique, coupled with Earths’ abundant and less toxic manganese catalysis, can prove to be a vital strategy for the generation of molecular complexity from simple starting materials. Manganese catalyzed DHC has been of growing interest, and various low‐ and high‐valent manganese catalysts have been developed. These catalysts were demonstrated to show excellent catalytic activity for the formation of carbon‐carbon, carbon‐heteroatom bonds, and cascade reactions. In this mini‐review, we would like to highlight the recent progress that has been made in manganese catalyzed ADC reactions.

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Organic Electrosynthesis: Applications in Complex Molecule Synthesis

2019

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Organic electrosynthesis is an enabling and sustainable technology, which constitutes a rapidly expanding field of research. Electrochemical approaches serve as convenient and green alternatives to stoichiometric and toxic chemical redox agents. Electrosynthesis constitutes a promising platform for harnessing the unique reactivity profiles of radical intermediates, expediting the development of new reaction manifolds. This Review highlights both anodic and cathodic methods for the construction of various kinds of complex molecules.

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Complex Molecule Synthesis, a Personal View

Cited by 6 publications

References 33 publications

Power of Biocatalysis for Organic Synthesis

Power of Biocatalysis for Organic Synthesis

Manganese Catalyzed Acceptorless Dehydrogenative Coupling Reactions

Organic Electrosynthesis: Applications in Complex Molecule Synthesis

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