Complex Lymphatic Anomalies: Report on a Patient Registry Using the Latest Diagnostic Guidelines

Complex lymphatic anomalies: Challenging diagnostic considerations

“…Although it is difficult to clearly ascertain which of the CLAs this patient had, the elevated angiopoietin‐2 and the hemorrhagic effusions make KLA more likely with possible contribution from GSD due to the cortical osteolysis found on imaging. This case emphasizes the difficulty of accurately classifying a CLA as the most commonly known distinctions may not be clearly evident and considerable overlap exists in findings; interestingly, a case series by Andreoti et al also described a patient with similar findings of both KLA and GSD 7 …”

“…This case emphasizes the difficulty of accurately classifying a CLA as the most commonly known distinctions may not be clearly evident and considerable overlap exists in findings; interestingly, a case series by Andreoti et al also described a patient with similar findings of both KLA and GSD. 7 This case report is one of few that describe the post-biopsy decompensation of a patient with a CLA. This patient's underlying lymphatic disease may have been naturally progressing, but the biopsies likely exacerbated the condition.…”

“…TTE was notable for a 20 mm × 13 mm mobile echodensity in the pericardial space adjacent to the mid lateral wall of the left T A B L E 1 Characteristics and management of the different complex lymphatic anomalies 1. [1][2][3][4]6,7 Type of CLA On postoperative day 2 of her sternotomy, the patient had to be intubated due to declining respiratory status secondary to mucus plugging. She remained intubated and 1 week later, she suffered a PEA cardiac arrest due to hypoxic respiratory failure.…”

Interdisziplinäres Management vaskulärer Anomalien im Kopf-Hals-Bereich

“…Zu den komplexen lymphatischen Malformationen gehören die generalisierte lymphatische Anomalie, (GLA), die lymphatischen Malformationen bei Gorham-Stout Syndrome (GSD), die kaposiforme Lymphangiomatosis (KLA), und die lymphatische Anomalie der zentralen sammelnden lymphatischen Gefäße (Central Conducting Lymphatic Anomaly-CCLA), auch "channel type" lymphatische Malformation genannt [69]. Komplexe lymphatische Malformationen sind selten und lassen sich anhand ihrer klinischen Ausprägung nicht immer sicher voneinander unterscheiden.…”

“…Complex lymphatic malformations include the generalized lymphatic anomaly (GLA), lymphatic malformations in Gorham-Stout syndrome (GSD), kaposiform lymphangiomatosis (KLA), and the lymphatic anomaly of the central collecting lymphatic vessels (central conducting lymphatic anomaly-CCLA), also known as "channel type" lymphatic malformation 69 . Complex lymphatic malformations are rare and cannot always be reliably distinguished from one another on the basis of their clinical manifestations.…”