Complex karyotypic evolution in B-cell chronic lymphocytic leukemia

Crossen, Peter E.; Tully, Sandra M.; Morrison, Mary J.; Heaton, D. C.; Benjes, Suzanne M.

doi:10.1016/0165-4608(91)90151-j

Cited by 7 publications

(1 citation statement)

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“…The majority of cases of clonal evolution involve the gain of chromosomes, although complex evolutions have also been reported (Crossen et al, 1991). T h e evolution in our case involved the acquisition of two abnormalities, a t(15;15) and a t(4; 13), in the cell line with the t(14;17).…”

Section: Add(8)(p23)der(14)t(l417)(pl I:ql L)-l7mentioning

confidence: 84%

Oligoclonal B‐cell leukemia characterized by spontaneous cell division and telomere association

Crossen

Tully

Benjes

et al. 1993

Genes Chromosomes & Cancer

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Cytogenetic analysis of unstimulated cultures from a female patient with chronic B-cell leukemia (CLL) revealed three cytogenetically distinct clones, suggesting that the patient's leukemia was oligoclonal. Immunoglobulin heavy chain gene rearrangement studies revealed 1 germline and 4 rearranged bands, indicative of an oligoclonal leukemic population. Further evidence of oligoclonality was provided by X-linked RFLP studies. This is the first report of oligoclonality in CLL demonstrated by cytogenetic, immunoglobulin gene rearrangement, and X-chromosome inactivation studies. In addition to oligoclonality, the patient's leukemic cells exhibited telomere association, a Robertsonian translocation, and clonal evolution, suggesting an underlying genomic instability.

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Section: Add(8)(p23)der(14)t(l417)(pl I:ql L)-l7mentioning

confidence: 84%