Complex interplay between RAS GTPases and RASSF effectors regulates subcellular localization of YAP
Swati Singh,
Gabriela Bernal Astrain,
Ana Maria Hincapie
et al.
Abstract:RAS GTPases bind effectors to convert upstream cues to changes in cellular function. Effectors of classical H/K/NRAS are defined by RBD/RA domains which recognize the GTP-bound conformation of these GTPases, yet the specificity of RBD/RAs for over 160 RAS superfamily proteins remains poorly explored. We have systematically mapped interactions between BRAF and four RASSF effectors, the largest family of RA-containing proteins, with all RAS, RHO and ARF small GTPases. 39 validated complexes reveal plasticity in … Show more
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