Complex interaction of circadian and non-circadian effects of light on mood: Shedding new light on an old story

Stephenson, Kathryn M.; Schröder, Carmen; Bertschy, Gilles; Bourgin, Patrice

doi:10.1016/j.smrv.2011.09.002

Cited by 107 publications

(100 citation statements)

References 129 publications

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“…In marked contrast, however, C3 mice actually consumed more ethanol under LD 18:6 than LD 6:18, opposite to the photoperiodic effect found in B6 mice in the present study [45]. While strain-dependent effects of photoperiod on ethanol intake have not been explored previously, numerous studies have reported lower levels of anxiety-and depression-like behavior under long photoperiods, or higher levels under short photoperiods, in diverse nocturnal and diurnal rodent species [52,56,57]. Nevertheless, affective responses to photoperiod appear to be far less consistent in mice [19,31], and indeed, C3 mice apparently display increased anxiety and depression under long photoperiods [3,31].…”

Section: Discussioncontrasting

confidence: 99%

Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice

Rosenwasser

Fixaris

McCulley

2015

Physiology & Behavior

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Section: Discussioncontrasting

confidence: 99%

Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice

Rosenwasser

Fixaris

McCulley

2015

Physiology & Behavior

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“…The nature of the circadian-homeostatic interaction is such that moderate changes in the timing of the sleep-wake cycle may have profound effects on subsequent mood. In addition, light, with its effects on circadian and non-circadian systems, seems to play a primordial role in mood regulation (Stephenson et al 2012).…”

Section: Sleep Disturbance Causes Waking Emotional Dysfunctionsmentioning

confidence: 99%

Sleep and Emotional Functions

Perogamvros

Schwartz

2013

Sleep, Neuronal Plasticity and Brain Function

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In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.

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“…The comparatively recent (past 100 yrs) experience of chronic exposure to light at night may therefore influence physiology and behavior through disruption of the parallel circadian and sleep systems (Navara & Nelson, 2007). Accumulating evidence has linked the circadian system with the immune (for review, see Scheiermann et al, 2013) and metabolic (Cho et al, 2012;Fonken et al, 2010;Yang et al, 2006) systems, as well as alterations in affective behavior (Bedrosian et al, 2011a(Bedrosian et al, , 2012LeGates et al, 2012;McClung, 2007;Stephenson et al, 2012). Understanding these connections is important for elucidating complex disease etiology and progression.…”

Section: Introductionmentioning

confidence: 99%

Dim Light at Night Does Not Disrupt Timing or Quality of Sleep in Mice

Borniger

Weil

Zhang

et al. 2013

Chronobiology International

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Artificial nighttime illumination has recently become commonplace throughout the world; however, in common with other animals, humans have not evolved in the ecological context of chronic light at night. With prevailing evidence linking the circadian, endocrine, immune, and metabolic systems, understanding these relationships is important to understanding the etiology and progression of several diseases. To eliminate the covariate of sleep disruption in light at night studies, researchers often use nocturnal animals. However, the assumption that light at night does not affect sleep in nocturnal animals remains unspecified. To test the effects of light at night on sleep, we maintained Swiss-Webster mice in standard light/dark (LD) or dim light at night (DLAN) conditions for 8-10 wks and then measured electroencephalogram (EEG) and electromyogram (EMG) biopotentials via wireless telemetry over the course of two consecutive days to determine differences in sleep timing and homeostasis. Results show no statistical differences in total percent time, number of episodes, maximum or average episode durations in wake, slow-wave sleep (SWS), or rapid eye movement (REM) sleep. No differences were evident in SWS delta power, an index of sleep drive, between groups. Mice kept in DLAN conditions showed a relative increase in REM sleep during the first few hours after the dark/light transition. Both groups displayed normal 24-h circadian rhythms as measured by voluntary running wheel activity. Groups did not differ in body mass, but a marked negative correlation of body mass with percent time spent awake and a positive correlation of body mass with time spent in SWS was evident. Elevated body mass was also associated with shorter maximum wake episode durations, indicating heavier animals had more trouble remaining in the wake vigilance state for extended periods of time. Body mass did not correlate with activity levels, nor did activity levels correlate with time spent in different sleep states. These data indicate that heavier animals tend to sleep more, potentially contributing to further weight gain. We conclude that chronic DLAN exposure does not significantly affect sleep timing or homeostasis in mice, supporting the use of dim light with nocturnal rodents in chronobiology research to eliminate the possible covariate of sleep disruption.

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Complex interaction of circadian and non-circadian effects of light on mood: Shedding new light on an old story

Cited by 107 publications

References 129 publications

Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice

Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice

Sleep and Emotional Functions

Dim Light at Night Does Not Disrupt Timing or Quality of Sleep in Mice

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