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BACKGROUND. The relevance of the study is due to limited information on the impact of various forms of rhinosinusitis that have arisen against the background of acute respiratory infection on the quality of life of children and effective treatment methods. AIMS: To conduct a clinical assessment of the effect on the recovery time and quality of life in children with acute rhinosinusitis and exacerbation of chronic polypous rhinosinusitis that occurred against the background of a respiratory infection, including antiviral drugs in complex treatment in the early stages. MATERIALS AND METHODS: A simple controlled randomized comparative clinical trial was conducted, involving 74 children aged 15 to 18 years. The clinical efficacy and safety of the use of antiviral drugs in complex therapy, which are neuraminidase inhibitors on the 5th, 7th and 10th days of treatment, were evaluated in comparison with groups receiving pentanedioic acid imidazolylethanamide. The inclusion criterion was acute rhinosinusitis and exacerbation of chronic polypous rhinosinusitis against the background of acute respiratory infection. To establish the diagnosis, an examination of ENT organs, computed tomography of the nose and paranasal sinuses were performed, patients subjectively assessed clinical complaints and quality of life in the Russian version of the standard form of the SF-36 questionnaire. RESULTS: Positive dynamics was noted in the early stages in the 2nd subgroup of the 1st group who took neuraminidase inhibitors in addition to complex therapy. manifested by a decrease in the average score for VAS to 80%, difficulty in nasal breathing to 1.7 points on the 10th day of treatment, relative to those taking imidazolylethanamide pentanedioic acid, where there was a decrease in the average score for VAS by 22.4%, difficulty in nasal breathing to 2.54 points. A similar pattern was observed with nasal congestion, rhinorrhea, and quality of life indicators according to the SF – 36 questionnaires. CONCLUSIONS: Improvement of clinical symptoms and quality of life indicators at an earlier date in children with chronic polypous rhinosinusitis and acute rhinosinusitis against the background of a previous respiratory infection with the inclusion of neuraminidase inhibitors in complex therapy confirmed higher efficacy.
BACKGROUND. The relevance of the study is due to limited information on the impact of various forms of rhinosinusitis that have arisen against the background of acute respiratory infection on the quality of life of children and effective treatment methods. AIMS: To conduct a clinical assessment of the effect on the recovery time and quality of life in children with acute rhinosinusitis and exacerbation of chronic polypous rhinosinusitis that occurred against the background of a respiratory infection, including antiviral drugs in complex treatment in the early stages. MATERIALS AND METHODS: A simple controlled randomized comparative clinical trial was conducted, involving 74 children aged 15 to 18 years. The clinical efficacy and safety of the use of antiviral drugs in complex therapy, which are neuraminidase inhibitors on the 5th, 7th and 10th days of treatment, were evaluated in comparison with groups receiving pentanedioic acid imidazolylethanamide. The inclusion criterion was acute rhinosinusitis and exacerbation of chronic polypous rhinosinusitis against the background of acute respiratory infection. To establish the diagnosis, an examination of ENT organs, computed tomography of the nose and paranasal sinuses were performed, patients subjectively assessed clinical complaints and quality of life in the Russian version of the standard form of the SF-36 questionnaire. RESULTS: Positive dynamics was noted in the early stages in the 2nd subgroup of the 1st group who took neuraminidase inhibitors in addition to complex therapy. manifested by a decrease in the average score for VAS to 80%, difficulty in nasal breathing to 1.7 points on the 10th day of treatment, relative to those taking imidazolylethanamide pentanedioic acid, where there was a decrease in the average score for VAS by 22.4%, difficulty in nasal breathing to 2.54 points. A similar pattern was observed with nasal congestion, rhinorrhea, and quality of life indicators according to the SF – 36 questionnaires. CONCLUSIONS: Improvement of clinical symptoms and quality of life indicators at an earlier date in children with chronic polypous rhinosinusitis and acute rhinosinusitis against the background of a previous respiratory infection with the inclusion of neuraminidase inhibitors in complex therapy confirmed higher efficacy.
Introduction. There is a clear need to discuss separate issues related to acute rhinosinusitis. The rationale is that prevalence rates of the disease remain high. At the same time, the incidence rates are growing globally, including Russia, Europe, the USA and Asia. Apart from that, acute rhinosinusitis significantly deteriorates the patients’ quality of life, causing physical, emotional and professional malaise. Moreover, the complications of acute rhinosinusitis may have serious consequences, and the economic costs to society are significant, including both explicit and implicit costs.Aim. To raise the level of awareness of otolaryngologists about current issues of acute rhinosinusitis based on the analysis and synthesis of literary sources.Materials and methods. An analysis of the published literature on the cause-and-effect relationship between the development and features of acute rhinosinusitis in the specialized academic research databases RSCI, eLibrary.Ru, Scopus, Web of Science, Medline over the last ten-year period was carried out.Results and discussion. We presented a brief overview of the etiology, epidemiology, risk factors, and diagnostic methods of acute rhinosinusitis based on the results of scientific literature review. The issues of treatment and prevention strategies, problems of antibiotic resistance are considered. The article brings to the fore the issues related to risk factors, among which it highlights an increasing incidence of acute respiratory viral infections, environmental and lifestyle influences. Modern diagnostic methods are addressed. We also emphasized the issues of improvement of clinical guidelines with a focus on recent research, stressed the importance of an individual approach to each patient, taking into account the severity and features of the course of the disease in individual patients.Conclusions. The paper considers a conceptual solution for providing medical care to patients with acute rhinosinusitis, which is based on the principles of evidence-based medicine and is regulated by legitimate clinical guidelines, both issued before and currently in force, including international ones.
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