Complex Hemodynamic Insult in Combination with Wall Degeneration at the Apex of an Arterial Bifurcation Contributes to Generation of Nascent Aneurysms in a Canine Model

Wang, J.; Tan, Hua-Qiao; Zhang, Donghui; Li, M.-H.; Li, Z.-Z.; Yan, Lei; Cheng, Ying-Sheng

doi:10.3174/ajnr.a3926

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…In canine models, disruption of internal elastic lamina, loss of medial smooth-muscle cells, reduced proliferation of smooth-muscle cells, and loss of fibronectin were observed at the regions with higher WSS than at the normal physiological levels [ 27 ]. Other studies also claimed that WSS higher than the normal physiologic level may disrupt the normal function of endothelial cells [ 28 29 ]. Therefore, increased WSS may impede neointimal formation which is induced by coil placement.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Characteristics Regarding Recanalization of Completely Coiled Aneurysms: Computational Fluid Dynamic Analysis Using Virtual Models Comparison

et al. 2016

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PurposeHemodynamic factors are considered to play an important role in initiation and progression of the recurrence after endosaccular coiling of the intracranial aneurysms. We made paired virtual models of completely coiled aneurysms which were subsequently recanalized and compared to identify hemodynamic characteristics related to the recurred aneurysmal sac.Materials and MethodsWe created paired virtual models of computational fluid dynamics (CFD) in five aneurysms which were initially regarded as having achieved complete occlusion and then recurred during follow-up. Paired virtual models consisted of the CFD model of 3D rotational angiography obtained in the recurred aneurysm and the control model of the initial, parent artery after artificial removal of the coiled and recanalized aneurysm. Using the CFD analysis of the virtual model, we analyzed the hemodynamic characteristics on the neck of each aneurysm before and after its recurrence.ResultsHigh wall shear stress (WSS) was identified at the cross-sectionally identified aneurysm neck at which recurrence developed in all cases. A small vortex formation with relatively low velocity in front of the neck was also identified in four cases. The aneurysm recurrence locations corresponded to the location of high WSS and/or small vortex formation.ConclusionRecanalized aneurysms revealed increased WSS and small vortex formation at the cross-sectional neck of the aneurysm. This observation may partially explain the hemodynamic causes of future recanalization after coil embolization.

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Section: Discussionmentioning

confidence: 99%

Hemodynamic Characteristics Regarding Recanalization of Completely Coiled Aneurysms: Computational Fluid Dynamic Analysis Using Virtual Models Comparison

et al. 2016

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“…When blood flow enters an arterial bifurcation, it exhibits complex hemodynamic features, some of which may correlate with aneurysm formation. 2,5,15,16 In this study, we analyzed a series of MCA bifurcations with and without aneurysms and explored the hemodynamic factors involved in aneurysm development. We found that MCA aneurysms were commonly located on the inclined MCA bifurcations, consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

A Hemodynamic Mechanism Correlating with the Initiation of MCA Bifurcation Aneurysms

Huang¹,

Zeng²,

Tao³

et al. 2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Previous studies have reported that MCA bifurcation aneurysms usually emerge on inclined bifurcations; however, the reason is unclear. We designed this study to explore hemodynamic mechanisms that correlate with the initiation of MCA bifurcation aneurysms. MATERIALS AND METHODS: Fifty-four patients with unilateral MCA bifurcation aneurysms and 54 control patients were enrolled in this study after propensity score matching, and their clinical and CTA data were collected. We extracted the morphologic features of aneurysmal MCA bifurcations to build a simplified MCA bifurcation model and performed a computational fluid dynamics analysis. RESULTS: The presence of MCA aneurysms correlated with smaller parent-daughter angles of MCA bifurcations (P , .001). Aneurysmal MCA bifurcations usually presented with inclined shapes. The computational fluid dynamics analysis demonstrated that when arterial bifurcations became inclined, the high-pressure regions and low wall shear stress regions shifted from the apexes of the arterial bifurcations to the inclined daughter arteries, while the initial sites of MCA bifurcation aneurysms often overlapped with the shifted high-pressure regions and low wall shear stress regions. CONCLUSIONS: Our results suggest that the initiation of MCA bifurcation aneurysms may correlate with shifts of high-pressure regions and low wall shear stress regions that occur on inclined MCA bifurcations. ABBREVIATIONS: CFD ¼ computational fluid dynamics; HPR ¼ high-pressure region; LWSS ¼ low wall shear stress; LWSSR ¼ low wall shear stress region; PSM ¼ propensity score matching; RD ¼ ratio of diameter; ROC ¼ receiver operating characteristic T he occurrence of intracranial aneurysms is generally thought to be due to arterial wall weakening and/or the influence of hemodynamics. 1-4 Most studies on aneurysm etiology have focused on hemodynamics. Because the geometric shapes of intracranial arteries are diverse, their hemodynamics are also complex. Arterial bifurcations are common sites for intracranial aneurysms. The bifurcations are generally exposed to extreme hemodynamic stress; those with special morphologic features that significantly divert blood flow from the direction of flow of the parent vessels are a risk factor for aneurysm formation. 1,5,6 Previous studies have reported that the inclined MCA bifurcations with a widening angle are likely to harbor aneurysms, 7,8 but mechanisms by which the aneurysms develop on MCA bifurcations are controversial and need to be elucidated. 8-11 The present study was designed to extract the morphologic features of aneurysmal MCA bifurcations from clinical data, build a simplified MCA bifurcation model based on these extracted features, perform computational fluid dynamics (CFD) analysis on the aneurysmal MCA bifurcations and simplified models, and finally, to explore the hemodynamic mechanisms that could trigger aneurysm initiation. MATERIALS AND METHODS Case Selection and Matching Patients with unilateral MCA bifurcation aneurysms confirmed ...

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“…[ 128 ] 2014 X Surgical Rabbits Saccular and fusiform X Donzelli R. [ 129 ] 2014 X Surgical Rabbits Saccular X Erhardt S. [ 130 ] 2014 X Surgical Rabbits Saccular X Cebral J.R. [ 131 ] 2014 X Surgical Rabbits Saccular X X Wang J. [ 132 ] 2014 X Endogenous Dogs Saccular X ...…”

Section: Methodsmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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Complex Hemodynamic Insult in Combination with Wall Degeneration at the Apex of an Arterial Bifurcation Contributes to Generation of Nascent Aneurysms in a Canine Model

Abstract: BACKGROUND AND PURPOSE:The detailed mechanisms of cerebral aneurysm generation remain unclear. Our aim was to investigate whether specific hemodynamic insult in combination with arterial wall degeneration leads to the development of aneurysms in a canine model.

Cited by 14 publications

References 24 publications

Hemodynamic Characteristics Regarding Recanalization of Completely Coiled Aneurysms: Computational Fluid Dynamic Analysis Using Virtual Models Comparison

Hemodynamic Characteristics Regarding Recanalization of Completely Coiled Aneurysms: Computational Fluid Dynamic Analysis Using Virtual Models Comparison

A Hemodynamic Mechanism Correlating with the Initiation of MCA Bifurcation Aneurysms

Imaging of intracranial aneurysms in animals: a systematic review of modalities

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