Abstract:Scaffolding molecules are increasingly recognized as integral components of many signal transduction cascades. These are proteins without enzymatic function but contain membrane localization sequences, motifs for binding SH3 domains and tyrosine phosphorylation sites for binding SH2 domains. In hematopoietic cells, the Grb2-associated binder (Gab) family of scaffolding molecules couple to a plethora of cytokine receptors and receptor tyrosine kinases. There are three mammalian Gabs: Gab1, Gab2 and Gab3. Gab1 i… Show more
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