Complex Formation with Tetraazacycloalkane‐N,N′,N″,N‴‐tetraacetic Acids as a Function of Ring Size

Study of Copper(II) Polyazamacrocyclic Complexes by Electronic Absorption Spectrophotometry and EPR Spectroscopy

“…[25,28,29] Although the formation of binuclear complexes (M 2 L) has been observed in some cases in the solid state, [23] it appears to be negligible in solution. [20][21][22] Most of the Cu II tri-and tetraazamacrocyclic complexes present in aqueous solution are thus mononuclear and fiveor six-coordinate, with the metal ion probably bound to all the nitrogen atoms of the macrocyclic ring and to two or three carboxylate oxygens of its pendant arms. These Cu II complexes often display strong tetragonal distortions that normally result in a lengthening of the axial metal-ligand bonds and an associated compression of the four equatorial ones.…”

“…The stability constants in aqueous solution (at 298 K) of copper(II) complexes with polyaza ligands have been determined by several authors: NOTA, logK ML ϭ 21.63 (1  NaClO 4 ); [21] DOTA, logK ML ϭ 22.25 [0.1  (CH 3 ) 4 NNO 3 ], [22][23][24] 22.72 (0.1  KCl); [25] NOTP, logK ML ϭ 21.3 (1  KNO 3 ); [26] DOTP, logK ML ϭ25.4 (1  KNO 3 ). [27] The presence of protonated species in aqueous solution (MH n L, n is typically 1 or 2), along with the more stable nonprotonated form (ML), has been detected for some Cu II macrocyclic chelates.…”

Nanoscale detection of metal-labeled copolymers in patchy polymersomes

“…11 In the present study, the In DOTA PMPC macro CTA was mixed with a poly(ethylene oxide) (PEO) macro CTA 12 (1:1 molar ratio) and the mixture was chain ex tended targetting the formation of 1:1 In DOTA PMPC PHPMA/PEO PHPMA polymersomes (Figure 3a). Again, the indium labeling allows visualization of the PMPC domains with single chain resolution.…”

“…This is a well established complexing agent for many metal ions and already used in several medical applications. 12 In our first approach we synthesized a DOTA labeled poly(2 (methacryloyloxy)ethyl phosphorylcholine) poly(2 (diisopropylamino)ethyl methacry late) (DOTA PMPC PDPA) block copolymer. The polymer was achieved using atom transfer radical polymerization (ATRP, see SI), yielding an AB SS BA tetrablock as previously published by our group.…”

Copper-catalyzed amination in the synthesis of polyoxadiamine derivatives of aza- and diazacrown ethers

“…It has been widely used in the coordination studies with various metal cations including rare earth metals and lanthanides. [1][2][3][4] Well-studied are other tetrasubstituted tetraazamacrocycles like cyclen and cyclam (1,4,8,11-tetraazacyclotetradecane) with phosphonate, [5][6][7][8][9][10] amide, [11] nitrile, [12] primary and tertiary amino groups. [13,14] In many cases additional donor atoms are present in C-substituted macrocycles like cyclam [15,16] or crown ethers.…”