Complex formation studies on copper(II) and zinc(II) with asparagine and aspartic acid in aqueous solution

Lomozik, Lechoslaw; Wojciechowska, Anna; Jaskólski, M.

doi:10.1007/bf00799931

Cited by 29 publications

(28 citation statements)

References 8 publications

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“…The data obtained from the potentiometric titration (150-350 points in each titration) were subjected to computer analysis using the programs SUPERQUAD for the model selection and estimation of the stability constants [34] and HALTAFALL for determination of distribution of particular species [35]. The criteria of model verification were described earlier [36]. The samples for NMR study were prepared by dissolving CDP, CTP, Spm, 3,3,3-tet and Cu(NO 3 ) 2 in D 2 O and adjusting pH with addition of NaOD or DCl.…”

Section: Methodsmentioning

confidence: 99%

“…In both systems analysed, the complexation starts from pH of about 5.5, simultaneously with total deprotonation of the phosphate group of the nucleotide [36] which suggests that this donor group is the main coordination centre. The results of the spectra study indicate formation of the chromophore {N4,O} (e.g.…”

Section: Cu(ii)-cdp-333-tet and Cu(ii)-ctp-333-tetmentioning

confidence: 98%

“…Additional stabilisation in the above two complexes is indicated by lower log K e for the complexes CuHPut and CuSpd (5.00 and 11.70 [47]) in which the coordination is realised through one and three nitrogen atoms of the polyamine, respectively. The spectral parameters in the pH ranges of dominance of Cu(CTP)H 3 (Spm) and Cu(CTP)H(Spm) are k max = 698 and 609 nm, g i = 2.343 and 2.250, respectively (Table 4) which, by comparison with the parameters obtained in analogous systems [31,36,48,[51][52][53][54] indicates the coordination type {N,O} for Cu(CTP)H 3 (Spm) and {N3,O} for Cu(CTP)H(Spm). Therefore, in the complexes Cu(CTP)H 3 (Spm) and Cu(CTP)H(Spm) the phosphate group of the nucleotide and deprotonated nitrogen atoms of the polyamine take part in the coordination.…”

Section: Cucdp þ H 4 Spm Cuðcdpþh 4 ðSpmþmentioning

confidence: 99%

“…The procedure of measurements was described earlier [36,[38][39][40][41]. Table 1 presents the compositions, overall stability constants and equilibrium constants of the reaction of the molecular complex formation in the systems studied.…”

Section: Nucleotide/polyamine Metal Free Systemsmentioning

confidence: 99%

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Interaction centres of pyrimidine nucleotides: Cytidine-5′-diphosphate (CDP) and cytidine-5′-triphosphate (CTP) in their reactions with tetramines and Cu(II) ions

Gasowska

2005

Journal of Inorganic Biochemistry

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Section: Methodsmentioning

confidence: 99%

Section: Cu(ii)-cdp-333-tet and Cu(ii)-ctp-333-tetmentioning

confidence: 98%

Section: Cucdp þ H 4 Spm Cuðcdpþh 4 ðSpmþmentioning

confidence: 99%

Section: Nucleotide/polyamine Metal Free Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Interaction centres of pyrimidine nucleotides: Cytidine-5′-diphosphate (CDP) and cytidine-5′-triphosphate (CTP) in their reactions with tetramines and Cu(II) ions

Gasowska

2005

Journal of Inorganic Biochemistry

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“…Matsui ( 1981) explained the data obtained for the system cadmium(II)-ASG by assuming only the species CdL and CdLz, Walker et al (197 4) involved the species CdL 3 , as well. Also in the case of zinc(II), the presence of two (ZnL and ZnLz, Lomozik, 1983) or three (with ZnL 3 also, Baxter et al,197 4) species was assumed.…”

Section: Discussionmentioning

confidence: 99%

Asparagine as a ligand for cadmium(II), lead(II) and zinc(II)

Bottari

Festa

1996

Chemical Speciation & Bioavailability

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The behaviour of asparagine as ligand (L) towards cadmium(ll), lead(ll) and zinc(ll) has been studied at 25°C with 1.00 mol L _, NaCI as a constant ionic medium. Experimental data obtained by measuring the electromotive force of galvanic cells involving glass and amalgam electrode of cadmium, lead or zinc, respectively, are explained in terms of complex formation. The presence of CdL (log 13 = 3.05 ± 0.03), CdL 2 (log 13 = 5.40 ± 0.05), CdL 3 (log 13 = 6.15 ± 0.1) and ZnL (log 13 = 4.43 ± 0.03), Zn~ (log 13 = 7.95 ± 0.04), ZnL 3 (log 13 = 9.35 ± 0.07) is assumed, respectively. In the case of lead(ll), it is necessary to assume also the existence of complexes formed by assumption of protons: PbL (log 13 = 3.60 ± 0.03), PbL 2 (log 13 = 5.29 ± 0.05), PbHL (log 13 = 8.50 ± 0.1 ), PbH 2 L 2 (log 13 = 18.70 ± 0.1 ). The results are discussed and compared with those obtained for other amino acids.

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Asparagin‐ und Glutaminsäure als Liganden für Alkali‐ und Erdalkalimetalle: Strukturchemische Beiträge zum Fragenkomplex der Magnesiumtherapie

Schmidbaur

Classen

Helbig³

1990

Angewandte Chemie

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Professor Max Schmidt zurn 65. Geburtstag gewidmetMagnesium und andere Erdalkali-und Alkalimetalle spielen in der Biochemie praktisch aller lebenden Organismen eine bedeutende Rolle. Im Gegensatz zu den ,,Spurenelementen" sind diese ,,Mengenmetalle" in fast allen Zellen und Geweben (teilweise in erheblichen Konzentrationen) verbreitet, so daD eine regelmaBige Zufuhr unerlaDlich ist, wenn biologische Funktionen uneingeschrankt gewahrleistet sein sollen. In der modernen Medizin werden verschiedene Formen der Magnesiumtherapie empfohlen, um Magnesiummangel sowie erhohten Verlust rechtzeitig zu kompensieren, der entweder durch krankhafte Fehlfunktionen oder aber z. B. durch Transpiration auftreten kann. Dam kommen zahlreiche Formen der Prophylaxe. Derzeit wird Magnesium oral in Form von ,,Komplexen" mit unbedenklichen (wed ,,naturlichen") Liganden wie L-Aspartat, L-Glutamat, L-Pyroglutamat (Pidolat), Citrat und Orotat verabreicht. Analytische, elektrochemische und spektroskopische Untersuchungen waDriger Losungen dieser Praparate sowie Rontgenbeugungsuntersuchungen an kristailinen Proben verschafften eine detailliertere Kenntnis von der Natur dieser Koordinationsverbindungen. Es konnte gezeigt werden, daD nur bestimmte Kombinationen wirklich Magnesiumkomplexe sind, wahrend andere sowohl in Losung als auch im festen Zustand lediglich als Aquokomplexe vorliegen. Offenbar besteht in den jeweiligen Systemen (Metall, Anion, Wasser) eine empfindliche Balance zwischen den Energien aus Metallkomplexierung und Wasserstoffbriickenbindungen, die gerade auch fur die Carrier-Funktion des Liganden entscheidend ist. Im Vergleich mit Ca, Sr, Ba, Mn", Zn, Li, Na, und K, fur die Koordinationszahlen zwischen 4 und 9 gefunden werden, eiweist sich Mg als stereoselektives Metall, bei dem die oktaedrische Hexakoordination strikt eingehalten wird.

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Complex formation studies on copper(II) and zinc(II) with asparagine and aspartic acid in aqueous solution

Cited by 29 publications

References 8 publications

Interaction centres of pyrimidine nucleotides: Cytidine-5′-diphosphate (CDP) and cytidine-5′-triphosphate (CTP) in their reactions with tetramines and Cu(II) ions

Interaction centres of pyrimidine nucleotides: Cytidine-5′-diphosphate (CDP) and cytidine-5′-triphosphate (CTP) in their reactions with tetramines and Cu(II) ions

Asparagine as a ligand for cadmium(II), lead(II) and zinc(II)

Asparagin‐ und Glutaminsäure als Liganden für Alkali‐ und Erdalkalimetalle: Strukturchemische Beiträge zum Fragenkomplex der Magnesiumtherapie

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