Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice

Blossom, Sarah J.; Melnyk, Stepan; Simmen, Frank A.

doi:10.1039/c9em00514e

Cited by 2 publications

(1 citation statement)

References 77 publications

(84 reference statements)

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“…However, these limitations are also opportunities to better translate diet heterogenity into PD risk from the preclinical research stage, as human data already confirms that certain diets may influence PD risk from pesticide exposure, such as paraquat and rotenone [ 94 ]. Likewise, specific diets can potentiate neurotoxicity of environmental contaminants, as was observed in offspring from high fat diet-fed female mice combined with TCE exposure [ 95 ], which caused epigenetic and redox alterations in the cerebellum. More studies are needed to examine the connection between widespread environmental contaminants and diet in mechansims of parkinsonism that carefully controlled basic or laboratory research studies can provide in support of human population data.…”

Section: Pre-clinical and Basic Research: From Molecular Biology To A...mentioning

confidence: 99%

Preventing Parkinson’s Disease: An Environmental Agenda

Miranda

Goldman

Miller

et al. 2022

JPD

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Fueled by aging populations and continued environmental contamination, the global burden of Parkinson’s disease (PD) is increasing. The disease, or more appropriately diseases, have multiple environmental and genetic influences but no approved disease modifying therapy. Additionally, efforts to prevent this debilitating disease have been limited. As numerous environmental contaminants (e.g., pesticides, metals, industrial chemicals) are implicated in PD, disease prevention is possible. To reduce the burden of PD, we have compiled preclinical and clinical research priorities that highlight both disease prediction and primary prevention. Though not exhaustive, the “PD prevention agenda” builds upon many years of research by our colleagues and proposes next steps through the lens of modifiable risk factors. The agenda identifies ten specific areas of further inquiry and considers the funding and policy changes that will be necessary to help prevent the world’s fastest growing brain disease.

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Section: Pre-clinical and Basic Research: From Molecular Biology To A...mentioning

confidence: 99%