Complex coacervation: Principles, mechanisms and applications in microencapsulation

Timilsena, Yakindra Prasad; Akanbi, Taiwo O.; Khalid, Nauman; Adhikari, Benu; Barrow, Colin J.

doi:10.1016/j.ijbiomac.2018.10.144

Cited by 356 publications

(199 citation statements)

References 110 publications

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“…For example, mononuclear droplets tend to form at low stirring rate, whereas multinuclear droplets tend to form at high stirring rate. [ 105,106 ]…”

Section: Potential Applications Of Coacervatementioning

confidence: 99%

Recent Advances in Complex Coacervation Design from Macromolecular Assemblies and Emerging Applications

Zhou

Shi

Liu

et al. 2020

Macromol. Rapid Commun.

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Coacervation is a process during which a homogeneous aqueous solution undergoes liquid–liquid phase separation, giving rise to two immiscible liquid phases composed of a colloid‐rich coacervate phase in equilibrium with a colloid‐poor phase simultaneously. Recent attempts to develop complex coacervation from macromolecular self‐assemblies have diversified a large group of novel coacervate‐related materials with sophisticated properties and emerging applications. In this review, the most recent progress in the design strategies of macromolecular complex coacervation is discussed with respect to different key parameters, including macromolecular structure, mixing ratio, ionic strength, pH, and temperature, etc. Furthermore, the applications of these multiple‐functional coacervate materials, oriented toward advanced encapsulation, are further summarized into several active domains in wastewater treatment, protein purification, food formulation, underwater adhesives, drug delivery, and cellular mimics. Finally, perspectives and future challenges related to the further advancement of macromolecular complex coacervates are proposed.

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“…For example, mononuclear droplets tend to form at low stirring rate, whereas multinuclear droplets tend to form at high stirring rate. [ 105,106 ]…”

Section: Potential Applications Of Coacervatementioning

confidence: 99%

Recent Advances in Complex Coacervation Design from Macromolecular Assemblies and Emerging Applications

Zhou

Shi

Liu

et al. 2020

Macromol. Rapid Commun.

View full text Add to dashboard Cite

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“…The conventional complex coacervates are formed by oppositely charged polyelectrolytes due to electrostatic interaction . Complex coacervation‐based adhesives have been reported by several groups.…”

Section: Protein‐based Adhesivesmentioning

confidence: 99%

Fabrication and Mechanical Properties of Engineered Protein‐Based Adhesives and Fibers

Sun

et al. 2019

Advanced Materials

107

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Protein-based structural biomaterials are of great interest for various applications because the sequence flexibility within the proteins may result in their improved mechanical and structural integrity and tunability. As the two representative examples, protein-based adhesives and fibers have attracted tremendous attention. The typical protein adhesives, which are secreted by mussels, sandcastle worms, barnacles, and caddisfly larvae, exhibit robust underwater adhesion performance. In order to mimic the adhesion performance of these marine organisms, two main biological adhesives are presented, including genetically engineered protein-based adhesives and biomimetic chemically synthetized adhesives. Moreover, various protein-based fibers inspired by spider and silkworm proteins, collagen, elastin, and resilin are studied extensively. The achievements in synthesis and fabrication of structural biomaterials by DNA recombinant technology and chemical regeneration certainly will accelerate the explorations and applications of protein-based adhesives and fibers in wound healing, tissue regeneration, drug delivery, biosensors, and other high-tech applications. However, the mechanical properties of the biological structural materials still do not match those of natural systems. More efforts need to be devoted to the study of the interplay of the protein structure, cohesion and adhesion effects, fiber processing, and mechanical performance.

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“…Most of the proteins associated with these compartments contain low complexity domains (LCDs) or low complexity sequences (LCSs), which are intrinsically disordered domains enriched in specific amino acids . In contrast to complex coacervates, which largely rely on electrostatic interactions, these sequences tune a variety of weak, attractive intermolecular interactions that compete with the entropic cost associated with de‐mixing . These interactions, which include electrostatic, pi–cation, aromatic, and hydrogen‐bonding interactions, enable cells to quickly react to changes in the environment and control not only the process of phase separation but also the properties of the resulting compartments .…”

Section: Figurementioning

confidence: 99%

Adaptive Chemoenzymatic Microreactors Composed of Inorganic Nanoparticles and Bioinspired Intrinsically Disordered Proteins

et al. 2020

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The assembly of protein and inorganic nanoparticles represents an attractive approach to generate composite materials with multiple functions. Herein, we functionalize inorganic nanoparticles with intrinsically disordered protein domains associated with the formation of membraneless compartments in cells. These protein sequences, defined as low complexity domains (LCDs), encode intermolecular interactions that drive highly controlled, dynamic self‐assembly in response to environmental changes. We show that the properties of the LCDs can be transferred to inorganic nanoparticles, inducing controlled phase separation that is dynamic and responsive to ionic strength and pH. Specifically, we hybridize magnetic nanoparticles with multi‐domain proteins consisting of LCD domains and a globular enzyme, generating dynamic protein‐composite compartments that locally confine hybrid chemoenzymatic reactions and respond to external magnetic fields and changes in solution conditions.

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Complex coacervation: Principles, mechanisms and applications in microencapsulation

Cited by 356 publications

References 110 publications

Recent Advances in Complex Coacervation Design from Macromolecular Assemblies and Emerging Applications

Recent Advances in Complex Coacervation Design from Macromolecular Assemblies and Emerging Applications

Fabrication and Mechanical Properties of Engineered Protein‐Based Adhesives and Fibers

Adaptive Chemoenzymatic Microreactors Composed of Inorganic Nanoparticles and Bioinspired Intrinsically Disordered Proteins

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