Completion Rates of Treatment for Latent Tuberculosis Infection in Quebec, Canada From 2006 to 2010

Rivest, Paul; Street, Maria-Constanza; Allard, R. W.

doi:10.17269/cjph.104.3643

Cited by 11 publications

(16 citation statements)

References 10 publications

(8 reference statements)

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“…Based on prior studies, the type and duration of treatment are likely 2 of the most significant factors in predicting treatment completion for latent tuberculosis. 9,14 In a separate study, we found that the use of DOT was not associated with treatment completion when adjusted for type of treatment.…”

Section: Discussionmentioning

confidence: 78%

Factors That Influence Treatment Completion for Latent Tuberculosis Infection

et al. 2017

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Introduction:The aim of this study is to describe factors associated with noncompletion of latent tuberculosis infection (LTBI) therapy.Methods: We conducted a retrospective cohort study of adults who initiated LTBI treatment with isoniazid, rifampin, or isoniazid-rifapentine at 5 clinics. Demographic, treatment, and monitoring characteristics were abstracted. We estimated descriptive statistics and compared differences between completers and noncompleters using t tests and 2 tests. Results: The rate of completion across LTBI regimens was 66% (n ‫؍‬ 393). A greater proportion of noncompleters were unmarried, used tobacco and/or alcohol, and had more medical problems than completers (all P < .05). A larger proportion of noncompleters received charity care compared with completers (P < .001). The most common reason for treatment discontinuation was loss to follow-up; the majority of these participants were treated with the longest isoniazid-only regimen.Conclusions: Patients at risk of progression to active tuberculosis with factors associated with noncompletion may benefit from interventions that enhance adherence to LTBI therapy. These interventions could include enhanced outreach, incentive programs, or home visits. (J Am Board Fam Med 2017;30: 520 -527.)

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Section: Discussionmentioning

confidence: 78%

Factors That Influence Treatment Completion for Latent Tuberculosis Infection

et al. 2017

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“…Demographic factors were also associated with treatment adherence, although the results were inconsistent. Women were less likely to complete treatment than men, but results were inconsistent for age and place of birth …”

Section: Resultsmentioning

confidence: 97%

“…Women were less likely to complete treatment than men, 18,40,48,49,54 but results were inconsistent for age 31,32,45,53 and place of birth. 18,19,21,27,30,48…”

Section: Initiation and Adherence To Ltbi Treatmentmentioning

confidence: 93%

Barriers to treatment adherence for individuals with latent tuberculosis infection: A systematic search and narrative synthesis of the literature

Liu

Birch

Newbold

et al. 2018

Health Planning & Management

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“…The estimated lifetime risk of reactivation (active TB develop ing in a person with latent TB infection) is 5%-10%. 1 Based on cur rent estimates of treatment completion rates for latent TB infection of 16%-30%, 3,4 this could translate to an annual increase of 4000 cases of active TB. Although this projection may seem improb ably high relative to current rates, the massive data gaps and the ad hoc screening for latent TB infection [3][4][5] create challenges for accurate forecasting.…”

mentioning

confidence: 99%

“…1 Based on cur rent estimates of treatment completion rates for latent TB infection of 16%-30%, 3,4 this could translate to an annual increase of 4000 cases of active TB. Although this projection may seem improb ably high relative to current rates, the massive data gaps and the ad hoc screening for latent TB infection [3][4][5] create challenges for accurate forecasting. However, recent spikes in active TB cases in Ontario 5 and England, 6 which have been driven by reactivation of latent TB infec tion among foreignborn individuals, give cause for concern.…”

mentioning

confidence: 99%