Complete Surgical Resection of a 40-cm Leiomyosarcoma of the Large Bowel Mesentery

Nagarsheth, Nimesh P.; Nicastri, Daniel G.; Kashani, Massoud; Fried, Kenneth

doi:10.1016/j.jsurg.2006.11.007

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…1 Therefore, a mesenteric tumor tends to be large when it is found. 14 In this case, the laboratory studies were not diagnostic for LMS, but the imaging study was the key that made us suspect LMS. 15 CT usually shows an enhanced, predominantly solid mass with poorly enhanced irregular cystic regions that represent necrotic F I G U R E 3 Intraoperative findings and procedure.…”

Section: Discussionmentioning

confidence: 84%

“…A mesenteric tumor may present with palpable abdominal mass, distention, or discomfort, but it rarely causes symptoms, because of its mobility in the peritoneal space or fixation in the retroperitoneum 1 . Therefore, a mesenteric tumor tends to be large when it is found 14 . In this case, the laboratory studies were not diagnostic for LMS, but the imaging study was the key that made us suspect LMS 15 .…”

Section: Discussionmentioning

confidence: 84%

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A case of laparoscopic resection of leiomyosarcoma arising in the mesentery of descending colon: a case report and review of the literature

Koyama

Maeda

Minagawa

et al. 2020

Clinical Case Reports

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

A case of laparoscopic resection of leiomyosarcoma arising in the mesentery of descending colon: a case report and review of the literature

Koyama

Maeda

Minagawa

et al. 2020

Clinical Case Reports

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“…However, complete resection is often difficult due to large tumor size at presentation and recent studies have shown that resection margins may be the only significant predictor of local recurrence [ 4 , 15 ]. Moreover, complete primary surgical resection is critical for achieving the best overall outcome [ 16 ]. Other factors include tumor depth, histological grade, and metastasis at presentation [ 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature

et al. 2016

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BackgroundAbdominal leiomyosarcoma arising from the mesentery is a rare malignancy. It is an aggressive entity with an overall 5 year survival rate between 20 and 30 %. Surgical resection is the cornerstone of primary treatment and may be curative for localized disease. However, patients often develop intra-abdominal relapse and/or metastatic disease. If surgical resection is not feasible, palliative chemotherapy is the treatment of choice. However, there are no clear guidelines regarding chemotherapy; neither in the adjuvant nor advanced setting.Case presentationWe present a 40 year-old woman, with a mesenteric leiomyosarcoma, who underwent radical tumor resection and did not receive adjuvant oncological therapy. Three months postoperatively, she developed metastatic disease to the lungs and liver. After multidisciplinary assessment she received an unconventional histological-subtype-tailored chemotherapy comprising 3–4 regimens. Initially, there was a decrease both in number and size of metastases. Ultimately, an almost complete radiological response was seen. Subsequent surgical resection and radiofrequency ablation of residual metastatic foci in the liver and lung brought her into complete clinical remission. She is presently tumor free, 36 months following diagnosis of metastatic disease.ConclusionsTo our knowledge, this is the first report of a patient with metastatic mesenteric leiomyosarcoma who is in complete clinical and radiological long-term remission following very aggressive multimodal treatment; including intense poly-drug chemotherapy and without any demonstrable long-term side effects. Given the rarity of mesenteric leiomyosarcoma and lack of guidelines regarding oncological therapy, we suggest that multimodal therapy including aggressive chemotherapy, guided by a multidisciplinary team, is essential to achieve an optimal outcome.

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“…Patients with leiomyosarcoma of the bowel mesentery generally display a poor prognosis. The overall 5-year survival rate for this tumor is only 20% to 30% [8], and complete primary surgical resection is critical for achieving the best overall outcome [9]. Conversely, recurrence can occur after a delay of up to 5 years, so that close and longterm follow-up observation of such patients for 5 years or more, with particular attention to the gastrointestinal tract, liver, and lung, is necessary.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric leiomyosarcoma in a 13-year-old boy

Iwasaki

Kitaguchi

Kobayashi

2010

Journal of Pediatric Surgery

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Complete Surgical Resection of a 40-cm Leiomyosarcoma of the Large Bowel Mesentery

Cited by 4 publications

References 2 publications

A case of laparoscopic resection of leiomyosarcoma arising in the mesentery of descending colon: a case report and review of the literature

A case of laparoscopic resection of leiomyosarcoma arising in the mesentery of descending colon: a case report and review of the literature

Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature

Mesenteric leiomyosarcoma in a 13-year-old boy

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