Complete sequence of a new HLA-B35 allele found in a tribe of Mapuche Indians in the south of Argentina

Theiler, G.; Marcos, Y.; Kolkowski, E.; Lindel, Nancy; Capucchio, M.; Barrionuevo, Paula; Carnese, Francisco R.; Satz, M. L.

doi:10.1007/bf02199810

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…The 5 locus haplotypes appearing at least 3 times include approximately 70% of the A~C~B~DRB1 haplotypes previously observed in individuals from the United States with Spanish or Italian ancestry and a similar percent of the 20 most common 4 locus haplotypes in Mexican Americans . Haplotypes carrying alleles that were originally found in indigenous populations in Argentina or surrounding countries (eg, A*68:17 , B*35:09:01 , B*35:19 , B*48:03:01 ) are also observed. These include: A*68:17 ~ C*08:01:01 ~ B*35:19 ~ DRB1*04:03:01 ~ DQB1*03:02:01 (0.2%), A*68:17 ~ C*08:01:01 ~ B*48:03:01 ~ DRB1*14:06:02 ~ DQB1*03:01:01 (0.1%), and A*31:01:02:01 ~ C*04:01:01:01 ~ B*35:09:01 ~ DRB1*14:02:01 ~ DQB1*03:01:01 (0.2%).…”

Section: Resultsmentioning

confidence: 76%

“…The HLA characteristics of these immigrant communities are comparable to similar immigrants in the United States. 28,29 Furthermore, HLA alleles originally identified in indigenous populations found in Argentina and neighboring countries [11][12][13][14] appear in the registry volunteers: B*35:09 first described in a tribe of Mapuche Indians in the south of Argentina 30 ; A*68:17 identified in Kolla Amerindians of north-west Argentina 31,32 ; A*02:22, B*35:20 and B*35:21 from a population in SW Brazil and B*35:19 and 48:03 from populations in NE Argentina 12,33 ; B*39:05 in Amerindian populations from Mexico to Argentina. 36 The registry population also includes DRB1*08:02 and DRB1*08:07 originally described in indigenous populations.…”

Section: Discussionmentioning

confidence: 99%

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Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population

Hurley

Hou

Lázaro

et al. 2018

HLA

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Next generation DNA sequencing is used to determine the HLA-A, -B, -C, -DRB1, and -DQB1 assignments of 1472 unrelated volunteers for the unrelated donor registry in Argentina. The analysis characterized all HLA exons and introns for class I alleles; at least exons 2, 3 for HLA-DRB1; and exons 2 to 6 for HLA-DQB1. Of the distinct alleles present, there are 330 class I and 98 class II. The majority (~98%) of the cumulative allele frequency at each locus is contributed by alleles that appear at a frequency of at least 1 in 1000. Fourteen (18.2%) of the 77 novel class I and II alleles carry nonsynonymous variation within their exons; 52 (75.4%) class I novel alleles carry only single, apparently random, nucleotide variation within their introns/untranslated regions. Alleles encoding protein variation not usually detected by typing focused only on the exons encoding the antigen recognition domain are 1.0% of the class I assignments and 7.3% of the class II assignments (predominantly DQB1*02:02:01, DQB1*03:19:01, and DRB1*14:54:01). Updates to the common and well documented list of alleles include 10 alleles previously thought to be uncommon but that are found at least 30 times. Five locus haplotypes estimated using the expectation-maximization algorithm as present 3 or more times total 187. While the known HLA diversity continues to increase, the conservation of known allele sequences is remarkable. Overall, the HLA diversity observed in the Argentinian population reflects its European and Native American ancestry.

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Section: Resultsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population

Hurley

Hou

Lázaro

et al. 2018

HLA

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“…B*35092 and B*3518 were previously described by our group in North‐East Argentinean tribes ( 25). B*35091 was described by Theiler et al ( 29) in Mapuche Indians from South‐Argentina. Now, we add B*3519 found in all the Argentinean tribes included in the present study and B*3520 and B*3521 found in Terena Indians in Brazil.…”

Section: Resultsmentioning

confidence: 97%

“…Serological data ( 10, 12–17) and more recently, DNA‐sequence data ( 11, 18–22) suggest that few allelic lineages are present in the Amerindian HLA gene pools. In spite of this, many novel HLA‐class I alleles have been identified in indigenous tribes of North and South America ( 18–33). Some investigators have suggested that the HLA‐B locus is evolving more rapidly than the other loci in South American Indian tribes ( 8, 18, 21, 22).…”

mentioning

confidence: 99%

Novel HLA‐A and HLA‐B alleles in South American Indians

et al. 1999

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The human leukocyte antigen (HLA) complex includes the most polymorphic genes in humans. More than 600 allelic variants have been described in different populations. The HLA-B locus has contributed the largest number of alleles. Although Native American populations display a restricted number of HLA-alleles, many novel HLA class I alleles have been identified in indigenous communities of Central and South America. We have studied 248 unrelated individuals from three tribes of North-East Argentina and one from South-West Brazil, as well as 80 related individuals from the Brazilian tribe. In the course of this work, we found 8 new B-locus alleles and 2 novel A-locus alleles in these populations. Here we report the nucleotide sequences of A*0219, A*0222, B*3519, B*3520, B*3521, B*3912, B*4009 and B*4803 and we show their relationship with similar alleles. The new alleles B*35092 and B*3518 have been described by us in a previous paper. The possible mechanisms that may have produced these alleles over evolutionary time are discussed.

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“…Rather than single or clustered nucleotide differences that can be attributed to either point mutation or small segmental exchange, HLA-B*5110 is the product of a much larger recombination between an HLA-B*51 allele (HLA-B*SIOI, B*5102 or B*5103; Figure 2) and an HLA-B*40 allele (HLA-B*4002, B*4003 or B*4004; Figure 2). Exchange of nucleotides between HLA-B alleles in South American Amerindian populations appears to be a fairly common event and is usually the result of small segmental exchange resulting in the exchange of 1 to 27 nucleotides (1)(2)(3)(4)(5)(6). Only one allele of the previously described new alleles, HLA-B*4802, has a large recombination of 198 nucleotides (1).…”

Section: Resultsmentioning

confidence: 99%

Further diversification of the HLA‐B locus in Central American Amerindians: new B39* and B51* alleles in the Kuna of Panama

et al. 1997

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Several new HLA-B locus alleles have been discovered in South American Amerindians. By contrast, analysis of the MHC class I alleles of North American native populations has revealed few new HLA-B alleles. This suggests that the HLA-B locus is evolving rapidly in South American populations. Here we describe the HLA-B locus alleles present in individuals from a Central American tribe, the Kuna of Panama. Using a sequence-based typing technique that separates alleles by denaturing gradient gel electrophoresis (DGGE) followed by direct sequencing, we determined the HLA-B alleles from eight Kunas. Two of the HLA-B alleles present in the Kuna have been previously described in other South American Amerindian populations; one allele has been characterized in a Mexican-American. We characterized two new HLA-B alleles in the Kuna, HLA-B*3911 and HLA-B*5110. HLA-B*3911 differed from HLA-B*3905 by only a single nucleotide substitution in exon 3. This substitution resulted in an amino acid replacement of leucine by arginine at residue 156 in the alpha 2 domain. Such a change may affect the repertoire of peptides that are bound by this molecule. HLA-B*5110 differed significantly from other HLA-B*51 alleles in that it is the result of an unusually large intra-locus recombination event of minimally 216 nucleotides. This recombination results in an allele that is part HLA-B*51 and part HLA-B*40. Thus, more dramatic recombination events may also play a role in the rapid evolution of the HLA-B locus in Amerindians.

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Complete sequence of a new HLA-B35 allele found in a tribe of Mapuche Indians in the south of Argentina

Cited by 11 publications

References 7 publications

Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population

Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population

Novel HLA‐A and HLA‐B alleles in South American Indians

Further diversification of the HLA‐B locus in Central American Amerindians: new B39* and B51* alleles in the Kuna of Panama

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Complete sequence of a new HLA-B35 allele found in a tribe of Mapuche Indians in the south of Argentina

Cited by 11 publications

References 7 publications

Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population

Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population

Novel HLA‐A and HLA‐B alleles in South American Indians

Further diversification of the HLA‐B locus in Central American Amerindians: new B*39 and B*51 alleles in the Kuna of Panama

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Further diversification of the HLA‐B locus in Central American Amerindians: new B39* and B51* alleles in the Kuna of Panama