Complete Sequence and Annotation of the Mycoplasma phocirhinis Strain 852
            <sup>T</sup>
            Genome

Frasca, Salvatore; Gell, Jessy Castellanos; Kutish, G. F.; Michaels, Dina L.; Brown, Daniel R.

doi:10.1128/mra.00131-19

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Novel Mycoplasma spp. have been isolated recently from marine mammals and reptiles [51,[59][60][61][126][127][128][129][130], many of which are threatened and/or endangered groups and intractable for experimental infections needed to establish pathogenicity. Thus, there is a critical need for the development of alternative models to address the potential role of new Mycoplasma spp.…”

Section: Discussionmentioning

confidence: 99%

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Burne,

Richey,

Schoeb

et al. 2024

Transboundary and Emerging Diseases

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Most mycoplasmal infections result in chronic, clinically silent disease. In direct contrast, Mycoplasma alligatoris elicits a fulminant, multisystem disease in the natural host, Alligator mississippiensis (American alligator). The goals of the study were to better understand the disease in the natural host and to determine if the invertebrate model G. mellonella could serve as a surrogate alternate host. The survival of alligators infected intratracheally was dose dependent (p=0.0003), ranging from no mortality (102 CFU) to 100% mortality (108 CFU), with 60% mortality at the 104 and 105 CFU infectious dose. Microbial load in blood, joints, and brain was dose dependent, regardless of whether alligators were infected intratracheally or intravenously (p <0.002). Weight loss was similarly impacted (p <0.001). Experimental infection of the invertebrate Galleria mellonella mirrored the result in the natural host. In a dose response infection study, both larval survival curves and successful pupation curves were significantly different (p≤0.0001) and dose dependent. Infected insects did not emerge as moths (p <0.0001). Here, we describe the first study investigating G. mellonella as a surrogate model to assess the pathogenic potential of M. alligatoris. G. mellonella survival was dose dependent and impacted life stage outcome.

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Section: Discussionmentioning

confidence: 99%

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Burne,

Richey,

Schoeb

et al. 2024

Transboundary and Emerging Diseases

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“…M. phocicerebrale encodes one protein (DMC14_000785) with about 60% amino acid sequence similarity to the three orthologs of mycoplasmal protein M of Mycoplasma phocirhinis and about 40% similarity to the four orthologs of mycoplasmal protein M of Mycoplasma phocidae (11, 12). Protein M binds host IgG to block antigen-specific binding (13).…”

Section: Announcementmentioning

confidence: 99%

Complete Sequence and Annotation of the Mycoplasma phocicerebrale Strain 1049 ^T Genome

Frasca

Gell

Kutish

et al. 2019

Microbiol Resour Announc

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Complete Sequence and Annotation of the Mycoplasma phocirhinis Strain 852 ^T Genome

Abstract: The genome of Mycoplasma phocirhinis strain 852T was examined for determinants of tropism or virulence. It encodes multiple orthologs of an immunosuppressor that may predispose susceptibility to infection or influence outcomes of intercurrent diseases in marine mammals.

Cited by 2 publications

References 14 publications

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Complete Sequence and Annotation of the Mycoplasma phocicerebrale Strain 1049 ^T Genome

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Complete Sequence and Annotation of the Mycoplasma phocirhinis Strain 852 T Genome

Abstract: The genome of Mycoplasma phocirhinis strain 852T was examined for determinants of tropism or virulence. It encodes multiple orthologs of an immunosuppressor that may predispose susceptibility to infection or influence outcomes of intercurrent diseases in marine mammals.

Cited by 2 publications

References 14 publications

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Complete Sequence and Annotation of the Mycoplasma phocicerebrale Strain 1049 T Genome

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Product

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Complete Sequence and Annotation of the Mycoplasma phocirhinis Strain 852 ^T Genome

Complete Sequence and Annotation of the Mycoplasma phocicerebrale Strain 1049 ^T Genome