Complete response to therapy: why do primary central nervous system lymphoma patients not return to work?

Wiemann, Greta; Pertz, Milena; Kowalski, Thomas E.; Seidel, Sabine; Schlegel, Uwe; Thoma, Patrizia

doi:10.1007/s11060-020-03587-5

Cited by 4 publications

(10 citation statements)

References 36 publications

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“…Moreover, standardized measures of QoL and resilience should be included in further studies to support the understanding of associations between social cognition and everyday functioning in brain tumor patients. Furthermore, further research on sociocognitive abilities should additionally address patients' level of functioning in society (e.g., return to work [42]) and should specifically capture other relevant aspects of patients' social functioning (e.g., hobbies, sporting activities, gathering with friends and family) in a prospective manner.…”

Section: Discussionmentioning

confidence: 99%

“…Our results highlight that PCNSL patients differ from healthy controls in their social abilities even in the absence of (residual) disease itself. These problems may potentially account for difficulties in reintegration as observed in PCNSL survivors [42] and should be considered therapeutically. Successful interventions, which help patients to develop adequate strategies for the solution of social problems, have already been positively evaluated for patients with acquired brain injuries or psychiatric symptoms [62] as well as for pediatric brain tumor survivors [63].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, our study provides a fine-grained analysis of how PCNSL patients interpreted and dealt with difficult interpersonal situations by focusing both on the quality of freely generated problem-solving strategies and on the ability to identify optimal solutions when presented, among others. Based on previous reports of psychological burden (i.e., depression and anxiety) [9] and of difficulties in reintegration into work and everyday life after successful therapy of PCNSL [42], one may assume that sociocognitive impairment partly accounts for those difficulties. Therefore, we hypothesized that PCNSL patients might be impaired in understanding the emotional experiences of interaction partners and in providing appropriate solutions for interpersonal problems preventing them from interacting adequately with their social environment.…”

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confidence: 99%

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What Is on Your Mind? Impaired Social Cognition in Primary Central Nervous System Lymphoma Patients Despite Ongoing Complete Remission

Pertz

Kowalski

Thoma

et al. 2021

Cancers

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Within the past decades, long-term survival was achieved in a substantial fraction of primary central nervous system lymphoma (PCNSL) patients, expanding the focus of research to their quality of life (QoL). Social relationships crucially contribute to well-being in the context of adversity. Therefore, abilities that facilitate social interactions essentially determine QoL. The present study specifically targeted those sociocognitive abilities. Forty-three PCNSL patients with ongoing complete remission to therapy for at least one year and 43 healthy controls matched for age, gender and education were examined with standardized self-report and behavioral measures of social cognition. An impaired ability to comprehend others´ feelings was found in patients for both positive and negative mental states. Patients had difficulties in identifying the awkward element in challenging social situations, whereas the degree of discomfort experienced in those situations was comparable between groups. Both the production of optimal solutions for social situations and the mere recognition of these among less optimal strategies were impaired in patients. Clinicians should be aware of possible sociocognitive impairment and ought to address this in additional supportive interventions. Impaired sociocognitive abilities may entail social conflicts at a time when patients rely on social support. This, in turn, could detrimentally affect QoL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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What Is on Your Mind? Impaired Social Cognition in Primary Central Nervous System Lymphoma Patients Despite Ongoing Complete Remission

Pertz

Kowalski

Thoma

et al. 2021

Cancers

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“…8 However, for patients treated with more toxic treatments, the return-to-work rates are lower. 9,10 The risk of disability pension has been found to be higher than the general population in selected subgroups of lymphoma. 11,12 Patients with lymphoma have experienced improved survival rates in recent years.…”

Section: Introductionmentioning

confidence: 99%

Work Disability and Return to Work After Lymphoma: A Danish Nationwide Cohort Study

Maksten¹,

Jakobsen²,

Kragholm³

et al. 2023

CLEP

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Many patients diagnosed with lymphoma are of working age. Cancer patients are known to have a higher risk of sick leave and disability pension, but this has only been delineated for certain subtypes of lymphoma. Therefore, this study aimed at investigating the overall risk of disability pension for all lymphoma subtypes and at quantifying return to work for patients with lymphoma in work before diagnosis. Patients and Methods: Patients aged 18-60 years with lymphoma in complete remission (CR) diagnosed between 2000 and 2019 were included in the study. Using national registers, each patient was matched with five comparators from the general population with same sex, birth year, and level of Charlson Comorbidity Index. Risk of disability pension was calculated from 90 days after CR or end of treatment with competing events (death, retirement pension, early retirement pension, relapse for patients, or lymphoma diagnosis for comparators). Return to work for patients was calculated annually until 5 years after diagnosis for patients employed before diagnosis. Results: In total, 4072 patients and 20,360 comparators were included. There was a significant increased risk of disability pension for patients with all types of lymphoma compared to the general population (5-year risk difference: 5.3 (95% confidence interval (CI): 4.4;6.2)). Patients with non-Hodgkin lymphoma were more likely to get disability pension than patients with Hodgkin lymphoma (sexand age-adjusted 10-year risk difference: 2.9 (95% CI: 0.3;5.5)). One year after diagnosis, 24.5% of the relapse-free patients were on sick leave. Return to work was highest 2 years after diagnosis (82.1%). Conclusion:Patients with lymphoma across all subtypes have a significantly higher risk of disability pension. Return to work peaks at 2 years after diagnosis.

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“…Additionally, psychological changes in PCNSL should be carefully considered in clinical practice. Studies have shown that experiencing illness in life may lead PCNSL patients to reexamine their priorities and have a more positive view of life (Pertz et al, 2021), and patients who resumed work experienced fewer symptoms impacting their quality of life (Wiemann et al, 2020). Cognitive function and mental health are closely linked (Bai et al, 2023; Gehring et al, 2015), and cognitive training can significantly improve psychological health (Poggi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Cognitive Function, Anxiety, and Depression in Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

Liu

Hou

et al. 2023

Biological Research For Nursing

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Objective To retrospectively analyze the effects of different treatments on cognitive functioning, anxiety, and depression in patients with primary central nervous system lymphoma (PCNSL). Methods A comprehensive literature search was conducted in multiple databases including the Cochrane Library, CINAHL, PubMed, Web of Science, EMBASE, Sino Med, Wei Pu, Wan Fang, CNKI, and Google Scholar. The search included studies published through June 20, 2023, focusing on cognitive function, anxiety, and depression in adult patients newly diagnosed with PCNSL. Various measurement tools and scales were used to assess the primary outcomes. Descriptive systematic reviews were conducted to integrate the literature and summarize the effects of different treatment modalities on cognitive functioning, anxiety, and depression in PCNSL patients. This review was registered with PROSPERO (CRD42022370250). Results A total of 43 studies were included. Induction chemotherapy was associated with improved cognitive function and reduced anxiety and depression in the majority of patients. Whole-brain radiotherapy (WBRT) was found to lead to cognitive impairment, particularly in executive, attention, memory, and motor function. Low-dose WBRT, autologous stem cell transplantation (ASCT), and blood-brain barrier disruption (BBBD) treatments did not result in significant cognitive impairment. Anxiety and depression were observed to decrease over the long term. Conclusions Overall, the cognitive functioning, anxiety, and depression of patients with PCNSL can be improved with appropriate treatments. However, patients treated with WBRT are at a higher risk of cognitive decline compared to those receiving other treatment modalities. Therefore, special attention should be given to patients undergoing WBRT, and a comprehensive analysis should be conducted to reduce neurotoxicity and address early cognitive problems in these patients.

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Complete response to therapy: why do primary central nervous system lymphoma patients not return to work?

Cited by 4 publications

References 36 publications

What Is on Your Mind? Impaired Social Cognition in Primary Central Nervous System Lymphoma Patients Despite Ongoing Complete Remission

What Is on Your Mind? Impaired Social Cognition in Primary Central Nervous System Lymphoma Patients Despite Ongoing Complete Remission

Work Disability and Return to Work After Lymphoma: A Danish Nationwide Cohort Study

A Systematic Review of Cognitive Function, Anxiety, and Depression in Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

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