Complete response to nivolumab for metastatic renal cell carcinoma on hemodialysis patient; a case report

Abstract

A 73-year-old-male patient with hypertension and grade 3B chronic kidney disease underwent radical nephrectomy in the year 2000. As the renal function gradually worsened, the patient was started on hemodialysis in 2003. Eleven years after nephrectomy, the metastases were pointed out. The patient received sunitinib as first-line therapy. Thereafter, as the metastatic lesions became larger, we initiated nivolumab therapy (3 mg/m2 every 2 weeks). After 52 weeks, the metastatic lesions continued showing complete response (CR). No adverse effects were observed during nivolumab treatment.

Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature

“…Ansari et al reported one patient on dialysis with metastatic RCC who experienced over 22 months of progression-free survival from immunotherapy with nivolumab [25]. Similarly, Ito and his colleagues confirmed a complete clinical response to nivolumab in an elderly patient with metastatic renal cell carcinoma and end-stage renal disease [26]. Moreover, proteolytic enzymes metabolize nivolumab and ipilimumab into polypeptides and amino acids.…”

Nephrotoxicity of combination drug therapy in metastatic renal cancer

“…На настоящий момент однозначно сложно делать выводы о прогнозе для пациентов с терминальной стадией ХБП на фоне иммунотерапии злокачественного новообразования. Необходимо проводить дальнейшие исследования в данной группе для получения более репрезентативных выборок и оценки прогноза в зависимости от гистологического типа опухоли [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”