Complete resolution of Zoon balanitis with photodynamic therapy – a new therapeutic option?

Pinto-Almeida, Teresa; Vilaça, Susana; Amorim, Isabel R.; Costa, Virgílio; Alves, Rosário; Selores, Manuela

doi:10.1684/ejd.2012.1779

Cited by 8 publications

(3 citation statements)

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“…More recently, other therapeutic modalities have been used, including photodynamic and laser therapy [3, 18–20]. Photodynamic therapy, which has been used in refractory lesions, involves the application of topical porphyrin precursors (5-aminolaevulinic acid or methyl aminolevulinate) and subsequent exposure to a light source whose wavelength is appropriate for exciting the photosensitizing chemical substance [20].…”

Section: Discussionmentioning

confidence: 99%

Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris

Bari

Cohen

2017

Dermatol Ther (Heidelb)

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IntroductionZoon’s balanitis, also referred to as balanitis circumscripta plasmacellularis (BCP), is an idiopathic, benign inflammatory condition of the glans penis and foreskin most often seen in elderly uncircumcised men. A patient with a biopsy-confirmed diagnosis of BCP who was successfully treated with topical mupirocin ointment is described.MethodsThe PubMed database was searched with the key words: bactroban, balanitis, cell, circumscripta, mupirocin, plasma, plasmacellularis, tacrolimus, Zoon. The papers generated by the search and their references were reviewed.ResultsTreatments for BCP have previously included circumcision and topical calcineurin inhibitors. Our patient with BCP rapidly resolved after initiating treatment with mupirocin 2% ointment.ConclusionBCP is a benign dermatosis affecting the glans penis and foreskin. We confirm an earlier observation demonstrating successful management of this condition with topical mupirocin 2% ointment. Previously reported therapies include circumcision, topical calcineurin inhibitors, phototherapy, and laser therapy. However, based on our observations, topical mupirocin 2% ointment therapy may be considered for the initial management of patients with suspected BCP. Prompt response to mupirocin 2% ointment is highly suggestive of the diagnosis of BCP since morphologically similar skin conditions do not respond to this treatment.

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Section: Discussionmentioning

confidence: 99%

Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris

Bari

Cohen

2017

Dermatol Ther (Heidelb)

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“…Sie führen langfristig zu guten Erfolgen, wie anhand einer Studie mit 20 Patienten gezeigt werden konnte [16]. Eine andere Option ist die PDT, die gut toleriert wurde und wirksam war mit wenigen Nebenwirkungen [17]. Der Mechanismus der PDT könnte auf der Inaktivierung der B-Zellen beruhen, deren Zytokine dann keine weiteren Plasmazellen mehr anziehen würden.…”

Section: Diskussionunclassified

Balanitis circumscripta plasmacellularis Zoon

Moll

2021

Aktuelle Dermatologie

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ZusammenfassungDie Balanitis plasmacellularis Zoon (BPZ), zuerst beschrieben von J. J. Zoon, ist eine chronische entzündliche Dermatose, die histologisch definiert ist anhand eines subepithelialen, lymphohistiozytären Infiltrates mit vielen Plasmazellen. Dabei wurden ein Spektrum epithelialer Veränderungen und eine variable Zusammensetzung des Infiltrates beschrieben. Dadurch unterscheidet sie sich von der Erythroplasie Queyrat, obwohl beide klinisch sehr ähnlich sind. An der BPZ erkranken vorwiegend ältere, nicht zirkumzidierte, heterosexuelle Männer. Klinisch typisch sind scharf umschriebene, rötlich-glänzende Rundherde an der Dorsalseite der Glans mit Übergang auf den Sulcus und das innere Präputialblatt. Erosionen und flache Infiltrate können hinzukommen. Der Verlauf ist chronisch mit sehr geringen Beschwerden, etwas erhöhte Empfindlichkeit wird oft genannt. Die Pathogenese ist unklar. Barrierestörung und Infektionen, unterhalten durch Feuchtigkeit, Mangel an Hygiene, Traumata und Irritationen, werden diskutiert. Dafür spricht auch das spontane Abheilen nach Zirkumzision oder lokalen Therapien mit Mucipirocin oder Fusidinsäure. Lokale Steroide sind ebenfalls – wie in unserem Fall – effektiv. Eine proaktive Therapie mit Tacrolimus-Salbe scheint eine Option. Die plasmazelluläre Entzündung ist nicht auf das männliche Genitale beschränkt, auch eine Vulvitis plasmacellularis ist beschrieben sowie der Befall nahezu aller weiteren Schleimhäute.

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“…[484952] Till now, its precise mechanism of action is unknown, but it is proposed that the particular sensitivity of activated T-lymphocytes to PDT might induce immunosuppression with subsequent inhibition of cytokines attracting the plasma cells, thus inhibiting the colonization of plasma cells in the dermis. On analyzing the limited data in the literature, ALA-PDT seems to be slightly better than MAL-PDT.…”

Section: Diagnosismentioning

confidence: 99%

Zoon balanitis: A comprehensive review

Dayal

Sahu

2016

Indian J Sex Transm Dis

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The diagnosis and management of nonvenereal diseases are always a tough challenge for the dermatologist due to lack of studies on its diagnostic criteria and standard treatment guidelines. Zoon balanitis (ZB) is one of the benign nonvenereal dermatoses, which presents as a solitary, persistent erythematous plaque usually on the glans penis primarily in the uncircumcised, middle-aged to old-aged men. Although it was described by Zoon in 1952, its etiopathogenesis still remains hypothetical. This article provides an overview of the epidemiology, clinical presentation, histopathological features, and diagnostic criteria and diagnostic methods of ZB. In addition to this, it is rather very important to differentiate this lesion from its clinical equivocal lesions such as erythroplasia of Queyrat, infective and other inflammatory penile dermatoses, which has been discussed in this review. The treatment modalities have also been reviewed in details, and the importance of circumcision as the treatment of choice has been emphasized.

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Complete resolution of Zoon balanitis with photodynamic therapy – a new therapeutic option?

Cited by 8 publications

References 0 publications

Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris

Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris

Balanitis circumscripta plasmacellularis Zoon

Zoon balanitis: A comprehensive review

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