Complete regression of primary gastric plasmacytoma following Helicobacter pylori eradication

Papadaki, Helen Α.; Skordilis, Panagiotis; Minadakis, Georgios; Roussomoustakaki, Maria; Katrinakis, G; Psyllaki, Maria; Tzardi, Maria; Eliopoulos, George D.

doi:10.1007/s00277-003-0701-6

Cited by 26 publications

(14 citation statements)

References 18 publications

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“…It is still controversial whether or not H. pylori eradication is truly beneficial in the treatment of gastric plasmacytoma. 6,[9][10][11][12][13] In contrast to other cases, eradication therapy for H. pylori was not performed here.…”

Section: Discussionmentioning

confidence: 99%

Complete Endoscopic Resection of Very Early Stage Gastric Plasmacytoma

Kim¹,

Kim²,

Lee³

et al. 2010

Gut Liver

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Gastric plasmacytomas are very rare, and most are not detected until the disease has progressed to an advanced stage. However, there have been recent reports of cases of early-stage gastric plasmacytoma, in which neoplastic cells are confined to the mucosa or submucosa. Here we report a case of a very early stage gastric plasmacytoma that was confined to the lamina propria of the gastric mucosa. The lesion was successfully and completely removed by endoscopic submucosal dissection, and the surveillance endoscopy showed no recurrence during the follow-up of 40 months. This report appears to be the first documented case of complete endoscopic removal of a primary gastric plasmacytoma. (Gut Liver 2010;4: 547-550)

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Section: Discussionmentioning

confidence: 99%

Complete Endoscopic Resection of Very Early Stage Gastric Plasmacytoma

Kim¹,

Kim²,

Lee³

et al. 2010

Gut Liver

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“…These patients have splenomegaly, attributed to Hp -I [37]. Finally, complete regression of a primary gastric plasmacytoma [38] and of a primary extragastric thyroid mucosa-associated lymphoid tissue lymphoma [39] after eradication of Hp -I have been described.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

Diamantidis

Ioannidou-Papagiannaki²,

Kountouras³

et al. 2010

Acta Haematol

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Background/Aims/Methods: To determine the frequency of Helicobacter pylori infection (Hp-I) in 73 patients with myelodysplastic syndromes (MDS) and 40 controls, serologic analyses of Hp and ¹³C-urease breath tests (INFAI) were performed. Gastric mucosal biopsy specimens were obtained to determine the presence of Hp-I using a rapid urease test, i.e. the Campylobacter-like organism (CLO) test, and cresyl violet staining. Peripheral blood (PB) flow cytometry for CD3, CD4, CD8, CD14, CD19 and CD34 was conducted in 35 patients and in controls. Results:Hp-I was detected by: (a) serology in 75.34% of patients (p = 0.000), (b) INFAI in 57.69% of patients, (c) CLO in 60.71% of patients and (d) histological confirmation in 80.36% of patients (p = 0.001). No correlation between Hp-I and CD3, CD4, CD8, CD14, CD19 expression, leukemic transformation or death was observed. However, in 20 cases, significant variation in the PB lymphocytic proportion possibly attributable to Hp-I was ascertained, in contrast to the expected MDS ratio. Conclusion: Although there is no evidence for a causal relationship between Hp-I and MDS, the increased prevalence of Hp-I among the MDS patients is an interesting finding that deserves further investigation as it may indicate a common factor causing susceptibilities to both MDS and Hp-I or that Hp might influence the pathophysiology of MDS.

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“…Perhaps, the most important evidence of the association of H. pylori infection with plasma cell dyscrasias is that some plasmacytomas disappear after the eradication of H. pylori. The authors who have analyzed this facet of infection by H. pylori have agreed to recommending that in all patients with these manifestations be offered the opportunity of evaluated and eradicate the infection if present [243][244][245]. Other associations described include a clear interaction between MALT lymphoma of the stomach and MGUS [246] as well as Waldenström's disease and MALT [247].…”

Section: Plasma Cell Dyscrasiasmentioning

confidence: 99%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Helicobacter pylori infection is the most common infection of the human species, with developing countries displaying a marked disadvantage in contrast to developing countries. While H. pylori infection is asymptomatic in most infected individuals, it is intimately related to malignant diseases of the stomach, such as gastric cancer and gastric MALT lymphoma, as well as benign diseases, for example chronic gastritis and duodenal and gastric peptic ulcers. Since the discovery that gastric mucosa could be colonized by bacteria, evidence of greater than 50 extragastric manifestations has been reported, linking H. pylori infection and the development of diseases associated with cardiology, dermatology, endocrinology, obstetrics and gynecology, hematology, pneumology, neurology, odontology, ophthalmology, otorhinolaryngology, and pediatrics. This chapter presents the extragastric manifestations of H. pylori infection expressed through hematologic diseases; particularly those included in the international consensus, and discusses guidelines for the management of H. pylori infection, such as iron deficiency, vitamin B 12 (cobalamin) deficiency, and immune thrombocytopenia. Other manifestations reviewed include immune neutropenia, antiphospholipid syndrome, and plasma cell dyscrasias, such us monoclonal gammopathy of undetermined significance, multiple myeloma, and Henoch-Schönlein purpura.

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Complete regression of primary gastric plasmacytoma following Helicobacter pylori eradication

Cited by 26 publications

References 18 publications

Complete Endoscopic Resection of Very Early Stage Gastric Plasmacytoma

Complete Endoscopic Resection of Very Early Stage Gastric Plasmacytoma

High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

Helicobacter pylori and Hematologic Diseases

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