Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome

Kim, J.J.; Hwang, Kr R.; Choi, Yu Hyeon; Chae, S.J.; Park, C.W.; Choi, Doo Seok

doi:10.1016/j.fertnstert.2013.07.841

Cited by 9 publications

(16 citation statements)

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“…In our previous study, the prevalence (31.3%) of the IM/PCO subgroup, that is, PCOS without HA, was relatively higher than those in other ethnicities (6.9–18.2%) . Our subsequent multicenter study also found that 38.0% of 865 Korean women with PCOS showed the IM/PCO phenotype . Additionally, in large Chinese studies, 52.2% of 719 patients and 36.5% of 1731 patients had the IM/PCO phenotype .…”

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 58%

“…PCO is defined as either a 12 or more antral follicle count (AFC) measuring 2–9 mm in diameter or an increased ovarian volume >10 cm 3 . With these criteria, PCO was observed in 96.5% of patients, and the mean AFC ranged from 15 to 16 in our previous multicenter study . However, a Chinese study reported that the best threshold to diagnose PCOS was <6.3 cm 3 for volume and AFC > 10 .…”

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 78%

“…We reported the complete metabolic and phenotypic features of 865 untreated, consecutively recruited Korean women with PCOS . In this study, 99.3% of patients had IM.…”

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 99%

“…Thus, women with PCOS have an increased risk of metabolic syndrome (MetS), prediabetes, type 2 diabetes and potentially cardiovascular disease. Although the prevalence is diverse (20–70%) across background populations, obesity is also prevalent in women with PCOS . Early recognition and intervention might prevent metabolic morbidity in PCOS patients.…”

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 99%

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Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences

Kim

Choi

2019

J of Obstet and Gynaecol

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-aged women, and ethnic diversity has been reported in its manifestation. This review addressed phenotype and genetic studies in Asian women with PCOS. Generally, East Asians are less hirsute, and the hirsutism score cutoff is lower than the Caucasian counterpart. It is not clear whether there are any significant differences in the prevalence or severity of irregular menstruation (IM) or characteristics of polycystic ovary (PCO) across ethnicities. Interestingly, the IM/PCO subgroup is a relatively common phenotype in East Asian patients but not in Caucasian patients. The prevalence of insulin resistance in PCOS patients varies depending on the index used and the cutoff, but women with PCOS showed a higher degree of insulin resistance than those of controls across ethnicities. Lower body mass index (BMI) and lower prevalence of metabolic syndrome were reported in East Asian patients, but despite lower BMI, a comparative study reported that Asian women with PCOS were more likely to have diabetes compared with Caucasian patients, suggesting they also have metabolic complications. Unlike East Asian patients, South Asian patients showed an increased degree of hirsutism, early onset of symptoms, and severe insulin resistance and metabolic risks compared with Caucasians. Genetic components play important roles in the pathogenesis of PCOS, and genome-wide association studies of PCOS suggest that similar genetic risk factors exist between Asian and Caucasian patients. Continuous comparative studies are needed to standardize the diagnosis and management of PCOS across different ethnicities.

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Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 58%

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 78%

“…We reported the complete metabolic and phenotypic features of 865 untreated, consecutively recruited Korean women with PCOS . In this study, 99.3% of patients had IM.…”

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 99%

Section: Asian Characteristics Of the Clinical Presentation Of Pcosmentioning

confidence: 99%

See 2 more Smart Citations

Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences

Kim

Choi

2019

J of Obstet and Gynaecol

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“…Data derived from clinical populations suggest that women with ''classic'' PCOS (phenotypes A and B) are associated with more pronounced menstrual dysfunction (73,79); increased insulin levels (80), higher rates of insulin resistance (79,81,82), and risk for metabolic syndrome (72,83); body mass index (80) and prevalence of obesity (82); and more severe forms of atherogenic dyslipidemia (29,79), as compared with women diagnosed with nonclassic or nonhyperandrogenic PCOS phenotypes (phenotypes C and D). There is also some evidence that women with the PCOS phenotypes A and B have an increased risk of hepatic steatosis as compared with women with PCOS with the nonhyperandrogenic phenotype and compared with healthy controls (83,84).…”

Section: ''Classic'' Pcos (Phenotypes a And B)mentioning

confidence: 99%

Criteria, prevalence, and phenotypes of polycystic ovary syndrome

Lizneva

Suturina

Walker

et al. 2016

Fertility and Sterility

884

557

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Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive-aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitations of the current criteria used to diagnosis, particularly when studying adolescents and women in the peri- and postmenopause; and describes significant strides made in understanding the epidemiology of PCOS. This review recognizes that although there is a high prevalence of PCOS, there is increased variability when using Rotterdam 2003 criteria, owing to limitations in population sampling and approaches used to define PCOS phenotypes. Last, we discuss the distribution of PCOS phenotypes, their morbidity, and the role that referral bias plays in the epidemiology of this syndrome.

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Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention

Loos

Jiskoot

Timman

et al. 2021

Reproductive BioMedicine Online

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Research questionWhat is the effect of weight loss through different interventions (three-component lifestyle intervention with short message service (SMS+) vs three-component lifestyle intervention without SMS (SMS-) vs care as usual (CAU)) on PCOS characteristics (ovulatory dysfunction (OD), hyperandrogenism (HA), polycystic ovarian morphology (PCOM)) and phenotype distribution? DesignAnalysis of secondary outcome measures of a randomized controlled trial. Women (n=183) diagnosed with PCOS, a wish to become pregnant and a BMI >25 kg/m² were either assigned to a one-year three-component (cognitive behavioural therapy, diet, exercise) lifestyle intervention group, with or without SMS, or to CAU (advice to lose weight). ResultsThe prevalence of biochemical HA was 30.9% less in the SMS-group when compared to CAU after one year (p=0.027). Within-group analyses revealed significant improvements in OD (SMS+: -39.8% p=0.001, SMS-: -30.5% p=0.001, CAU: -32.1% p<0.001), biochemical HA (SMS-: -27.8% p=0.007) and PCOM (SMS-: -14.0% p=0.034). Finally, weight loss per se had a significant favourable effect on OD and HA. ConclusionsAll groups demonstrated improvements regarding PCOS characteristics, although these were more profound within the lifestyle intervention groups. Weight loss per se led to an amelioration of both the diagnostic characteristics as well as in the phenotype of PCOS.Hence, a three-component lifestyle intervention aiming at a 5-10% weight loss should be recommended for all women with PCOS before they get pregnant.

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Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome

Cited by 9 publications

References 0 publications

Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences

Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences

Criteria, prevalence, and phenotypes of polycystic ovary syndrome

Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention

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