Complete Penoscrotal Transposition with Other Extragenital Anomalies in a Neonate Delivered at Term

Ali, Mahamudu Ayamba; Maalman, Raymond Saa-Eru; Donkor, Yaw Otchere; Anyorigiya, John Noah

doi:10.1155/2021/6676301

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Complete major PST is a rare heterogeneous condition that result from abnormal genital tubercle development around the 6th week of gestation. 7,23 In this study, the lower incidence of complete major PST reflects the small number of hypospadias patients who might have abnormal penile development starting at nonhormonal phase when the development of genital tubercle occurred. Severe form of BS was also found in the majority of severe hypospadias cases in this study.…”

Section: Discussionmentioning

confidence: 75%

“…Although rare, scrotal anomalies are often found together with hypospadias. 5,[7][8][9] Currently, studies discussing scrotal anomalies in hypospadias are limited and mostly reported through case reports. A study by Fahmi et al discusses scrotal position disorders in children comprehensively but not specifically for children with hypospadias.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of associated scrotal anomalies in boys with hypospadias

Indriasari,

Felicia,

Diposarosa

et al. 2024

F1000Res

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Background Hypospadias is a common congenital anomaly of the penis characterized by ventral opening of urethra. This abnormality is often accompanied by scrotal abnormalities, where both penile and scrotal development occur at the same time during the fetal period. This study aims to analyze associated scrotal anomalies in children with hypospadias. Methods This is a retrospective cross-sectional study of boys diagnosed with hypospadias during a 6 years period. The age of patients, severity of hypospadias, and associated scrotal anomalies such as penoscrotal transposition (PST), bifid scrotum (BS), and scrotal hypoplasia were assessed. Scrotoplasty procedure was also recorded. The association between the severity of hypospadias, incidence of scrotal anomalies, severity of both PST and BF were analyzed using Chi-square test and alternatively Fisher exact test, p<0,05 considered significant. Results During the study period, there were 240 hypospadias patients, with a median age of 5,6 years. Most patients had severe hypospadias. Associated scrotal anomalies were found in 63,3% of patients. Incidence of scrotal anomaly was higher in patients with severe hypospadias (75%) compared to mild cases (75% vs 36.1%; p<0.001; PR= 2.08 (95% CI: 1.51 – 2.86)). Patients with severe hypospadias had a more severe PST, especially in bilateral minor and major forms compared to patients with mild cases (p<0.001); and was significantly associated with severe and partial type of SB (p<0.001). Patients with a more severe PST tend to have a more severe SB, on contrary, patients with minor PST tend to have a milder or even no BS (p<0.001). Scrotoplasty was performed in 35,4% of cases. Conclusion Most hypospadias patients had associated scrotal anomaly, in which severe hypospadias was associated with the more severe type of PST and BS.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Analysis of associated scrotal anomalies in boys with hypospadias

Indriasari,

Felicia,

Diposarosa

et al. 2024

F1000Res

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“…PST has been shown to frequently present with associated genitourinary defects, including hypospadias, chordee, and cryptorchidism (Arena et al, 2005; Fahmy et al, 2014; Parida et al, 1996; Pinke et al, 2001; Sexton et al, 2015). PST also co‐occurs with other congenital defects outside of the genitourinary system (e.g., gastrointestinal and cardiac abnormalities) (Ayamba et al, 2021; Parida et al, 1996; Pinke et al, 2001) though the largest study to date describing birth defects co‐occurring with PST included only 53 patients (Pinke et al, 2001). An analysis of these co‐occurring defects in a large population‐based sample is warranted.…”

Section: Introductionmentioning

confidence: 99%

An epidemiologic study of penoscrotal transposition by maternal characteristics using data from the Texas birth defects registry

Allred,

Nguyen,

Agopian

et al. 2023

Birth Defects Research

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BackgroundPenoscrotal transposition (PST) is an uncommon urogenital malformation in which the penis is mal‐positioned to be inferior to the scrotum. The purpose of this study was to explore PST risk by maternal characteristics and to describe co‐occurring congenital abnormalities in the Texas Birth Defects Registry (TBDR).MethodsWe conducted a population‐based descriptive study examining occurrence of PST in the TBDR between 1999 and 2019. The primary outcome variable was PST diagnosis during infancy. Descriptive variables included maternal age, education, and race/ethnicity. Prevalence ratios (PRs) were calculated within each maternal variable category using Poisson regression. Counts and percentages of cases with select co‐occurring congenital abnormalities were also calculated.ResultsOverall, 251 infants had PST, providing a prevalence of 0.61/10,000 live male births (95% CI: 0.53–0.68). PST prevalence was significantly lower among infants of mothers who had lower educational attainment (<high school vs. >high school), who were younger (<25 vs. 25–34), and who were Hispanic (vs. non‐Hispanic White) and was significantly higher among older mothers (35+ vs. 25–39). Hypospadias was the most common co‐occurring genitourinary anomaly, affecting close to 70% of cases.ConclusionsTo our knowledge, this is the first investigation exploring the prevalence of PST in a population‐based birth defects registry. Our findings help to understand the risk for PST among select maternal demographic characteristics and may assist in generating hypotheses about the underlying etiology of this condition for future work.

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