Complete pathological response of multiple huge liver metastases of colon cancer: a case report

Hakoda, Keishi; Yoshimitsu, Masanori; Emi, Manabu; Omori, Ichiro; Kohashi, Toshihiko; Kaneko, Mayumi; Ohdan, Hideki; Hirabayashi, Naoki

doi:10.1093/omcr/omx016

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…This resistance is an important obstacle to treatment that can result in chemotherapy failure in many cancers, including colon cancer ( 3 ). Therefore, the identification of safe and effective agents that specifically target drug-resistant cancers, is vital for the future treatment of colon cancer ( 4 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

Suppression of YAP by DDP disrupts colon tumor progression

Guo

et al. 2018

Oncol Rep

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Colon cancer is a commonly diagnosed cancer that often has a poor prognosis. Combined with the development of drug resistance to cancer treatment agents the treatment efficacy of colon cancer can be limited. Activation of the oncogene YAP has been shown to be related to colon cancer progression and is associated with poor prognosis, drug resistance and metastasis, even under treatment. Cisplatin (DDP) is a commonly used drug that can control carcinoma progression, although its mechanisms are poorly understood. In the present study, we examined whether DDP specifically suppressed YAP in order to inhibit colon carcinoma progression. Our data revealed that Mst/Yap signaling was unusually activated in colon cancers, promoting cell proliferation and invasion. DDP treatment decreased the expression of YAP at both the transcriptional and post-translational levels, leading to cell cycle arrest, apoptosis and senescence in cancer cells, in addition to decreasing epithelial-to-mesenchymal transition, cell motility and in vitro cell invasion and migration. Ultimately, DDP increased the expression of E-cadherin and decreased the expression of vimentin. The present study also revealed that post-translational regulation of YAP phosphorylation controlled the subcellular distribution between the nucleus and the cytoplasm. In conclusion, the findings of the present study revealed that DDP was a suitable therapeutic candidate for colon cancer that specifically targets the Mst/Yap signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Suppression of YAP by DDP disrupts colon tumor progression

Guo

et al. 2018

Oncol Rep

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“…Preparation of neoplasm nuclear macromolecule Extracts: for estimation of total protein content and HDAC activity by employing a membrane, nuclear and protoplasm macromolecule extraction kit equipped by Biobasic INC. Canada [27].…”

Section: Tissue Samplingmentioning

confidence: 99%

Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

El-Keey¹,

Ibrahim²,

El-Ghonamy³

et al. 2020

JBM

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Histone acylation is one in every of the posttranslational modification that incorporates a role within the regulation of sequence expression. This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). In this study, sulforaphane was extracted from cabbage leaves and evaluated victimization GC-MS and ultraviolet illumination spectrophotometry. 60 white male rats were divided into six equal groups. Group I: management ordinarily. The remaining mice were subjected to Ehrlich neoplasm cells. Group II: Tumor-bearing group. Group III: immune suppressant drug "MTX" treated group. Group IV, V treated with SFN before and when Paul Ehrlich cells implantation group VI (Methotrexate and sulforaphane-treated group). This result showed that sulforaphane was extracted from cabbage (Brassica oleracea) in concentration of 833 µg/g leave. HDAC was attenuated when treatment with sulforaphane after treatment with methotrexate or sulforaphane alone. The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis.

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“…With the development of preoperative chemotherapy, new clinicopathological factors have emerged. Pathologic complete response (PCR), which is defined as the absence of any residual cancer cells, has been proven to confer an extremely favorable response to chemotherapy and can serve as an indicator of good prognosis [21][22][23][24][25][26][27]. However, its applicability to CRLM is limited because only approximately 5% of these patients achieve all-lesion PCR, with the vast majority achieving only partial-lesion PCR [23,28].…”

Section: Introductionmentioning

confidence: 99%

The Pathologic Complete Response Ratio of Liver Metastases Represents a Valuable Prognostic Indicator

et al. 2022

Pathol. Oncol. Res.

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Background and Objectives: The aim of this study was to evaluate the role of the pathologic complete response ratio of liver metastases (PCRRLM) in predicting the prognosis and recurrence of colorectal cancer liver metastases (CRLM).Methods: A total of 305 CRLM patients who underwent preoperative chemotherapy followed by hepatectomy were included. PCRRLM was defined as the number of liver metastases exhibiting pathologic complete response (PCR) divided by the number of total resected liver metastases. The Kaplan–Meier method was used to calculate survival, and differences were examined by the log-rank test. Univariate and multivariate analyses were performed to identify the predictors of PCRRLM, recurrence-free survival (RFS) and overall survival (OS).Results: Among the 305 included patients, 44 (14.4%) achieved a PCRRLM ≥0.50 (including PCRRLM = 1), and 261 (85.6%) achieved a PCRRLM <0.50 (including PCRRLM = 0). Patients of an older age (≥55 years old) and those with higher carcinoembryonic antigen (CEA) levels (≥5 ng/ml) were less likely to achieve a PCRRLM ≥0.50. In the multivariate analysis, PCRRLM≥ 0.50 (vs. < 0.50, HR [95% CI]: 0.67 [0.46–0.99], p = 0.043) was associated with better RFS. Positive lymph node status (vs. negative, HR [95% CI]: 1.46 [1.04–2.05], p = 0.028) and TBS ≥5 (vs. < 5, HR [95% CI]: 1.44 [1.02–2.04], p = 0.038) were associated with worse RFS.Conclusion: PCRRLM was significantly associated with long-term RFS after preoperative chemotherapy and CRLM resection. Thus, it may be a valuable indicator of recurrence in CRLM patients.

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Complete pathological response of multiple huge liver metastases of colon cancer: a case report

Cited by 4 publications

References 9 publications

Suppression of YAP by DDP disrupts colon tumor progression

Suppression of YAP by DDP disrupts colon tumor progression

Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

The Pathologic Complete Response Ratio of Liver Metastases Represents a Valuable Prognostic Indicator

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