Complete Ophthalmoplegia Secondary to Amyloidosis Associated with Multiple Myeloma

Raflo, Gary T; Farrell, Thomas A.; Sioussat, Robert S.

doi:10.1016/0002-9394(81)90775-3

Cited by 29 publications

(4 citation statements)

References 16 publications

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“…A review of the literature revealed 21 cases of localized EOM amyloidosis and 9 cases of systemic amyloidosis with EOM infiltration (Table 1). 2–29 The most common clinical findings were ophthalmoplegia (63.3%), diplopia (56.7%), and proptosis (30.0%). Patients with systemic amyloidosis were more likely to have multiple muscles affected (55.6% multiple muscles cf 11.1% single muscle involvement).…”

Section: Resultsmentioning

confidence: 99%

Clinical and Radiological Features of Intramuscular Orbital Amyloidosis: A Case Series and Literature Review

Tong

Juniat

McKelvie

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Orbital amyloidosis of the extraocular muscles (EOMs) is a rare condition, and its clinicoradiological features are not well elucidated. This study describes the characteristic clinical signs, MRI features, and potential treatment options. Methods: Retrospective multicenter case series and literature review of EOM amyloidosis. Results: Five cases were identified for inclusion. Common clinical findings were diplopia, ophthalmoplegia, and proptosis. Systemic amyloidosis was more likely to present with multiple muscle involvement, but no particular pattern was observed with localized disease. On MRI, amyloid deposition was characterized as a heterogeneous intramuscular mass with T2 hypointensity and post contrast enhancement. Management is dependent on the extent of disease and functional impairment; options include surgical debulking and radiation therapy. Conclusion: EOM amyloidosis is uncommon. The combination of clinical and radiologic findings described in this study should lead to its clinical suspicion.

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Section: Resultsmentioning

confidence: 99%

Clinical and Radiological Features of Intramuscular Orbital Amyloidosis: A Case Series and Literature Review

Tong

Juniat

McKelvie

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Others have reported ptosis as a presenting sign in 50% of patients with periorbital amyloid 1. Eyelid amyloidosis can be part of a systemic disorder or localized to the eye and adnexa 131415161718. In this series all patients had localized eyelid or adnexal amyloid infiltration without conjunctival involvement, eyelid amyloidosis is more frequently reported as an extension of conjunctival amyloid into the eyelid19202122 whereas, amyloid primarily localized to the eyelid as seen in three cases in this series is uncommon.…”

Section: Discussionmentioning

confidence: 99%

Anterior orbit and adnexal amyloidosis

Hussain

Edward

2013

Middle East Afr J Ophthalmol

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Purpose:To describe six cases of anterior orbital and adnexal amyloidosis and to report on proteomic analysis to characterize the nature of amyloid in archived biopsies in two cases.Materials and Methods:The clinical features, radiological findings, pathology, and outcome of six patients with anterior orbit and adnexal amyloidosis were retrieved from the medical records. The biochemical nature of the amyloid was determined using liquid chromatography/mass spectroscopy archived paraffin-embedded tissue in two cases.Results:Of the six cases, three had unilateral localized anterior orbit and lacrimal gland involvement. Four of the six patients were female with an average duration of 12.8 years from the time of onset to presentation eyelid infiltration by amyloid caused ptosis in five cases. CT scan in patients with lacrimal gland involvement (n = 3) demonstrated calcified deformable anterior orbital masses and on pathological exmaintionamyloid and calcific deposits replaced the lacrimal gland acini. Ptosis repair was performed in three patients with good outcomes. One patient required repeated debulking of the mass and one patient had recurrenct disease. Proteomic analysis revealed polyclonal IgG-associated amyloid deposition in one patient and AL kappa amyloid in the second patient.Conclusion:Amyloidosis of the anterior orbit and lacrimal gland can present with a wide spectrum of findings with good outcomes after surgical excision. The nature of amyloid material can be precisely determined in archival pathology blocks using diagnostic proteomic analysis.

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“…To our knowledge, this is the first report of AM presenting external ophthalmoparesis involving the extraocular muscles, although ophthalmologists have reported a few cases of external ophthalmoparesis with systemic amyloidosis [4][5][6]9].…”

Section: Akihiko Hoshi Masahiro Ebitani Gaku Tanaka Kouichirou Nakamumentioning

confidence: 99%

Amyloid myopathy with external ophthalmoparesis

et al. 2009

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Complete Ophthalmoplegia Secondary to Amyloidosis Associated with Multiple Myeloma

Cited by 29 publications

References 16 publications

Clinical and Radiological Features of Intramuscular Orbital Amyloidosis: A Case Series and Literature Review

Clinical and Radiological Features of Intramuscular Orbital Amyloidosis: A Case Series and Literature Review

Anterior orbit and adnexal amyloidosis

Amyloid myopathy with external ophthalmoparesis

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