Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin

Verhoeyen, Martine; Rompuy, Ludo Van; Jou, Willy Min; Huylebroeck, Danny; Fiers, Walter

doi:10.1093/nar/11.14.4703

Cited by 49 publications

(33 citation statements)

References 37 publications

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“…1 shows the chronological surveillance of influenza viruses isolated by municipal and prefectural public health laboratories throughout Japan during 1985-91 [12]. In the 7 influenza seasons in this period, there were 6 epidemics [14] strains are also included. Only the nucleotide sequences of the HAI region are shown.…”

Section: And Discussionmentioning

confidence: 99%

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Comparison of the HA genes of type B influenza viruses in herald waves and later epidemic seasons

et al. 1992

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SUMMARYFrom January 1985 to May 1991, herald strains of influenza B virus were isolated in 1987 and 1989 in Japan. In both cases, influenza epidemics caused by the same type followed in the next winter season. The HA gene sequences of the influenza B viruses isolated in Japan from 1987–91, which covers two herald waves of influenza B viruses, were analysed and located on the phylogenetic tree for influenza B viruses after the B/Singapore/64 strain. Co-circulation of at least two evolutionary lineages of the HA genes existed for influenza B viruses in Japan during the period of this study. The herald viruses in one wave (1987) were genetically close to the winter isolates and were considered to be the parental viruses for the following influenza season, while in the other wave (1989) winter isolates belonged to another lineage on which one of the herald viruses was located, but they were genetically and antigenically different from the herald viruses.

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Section: And Discussionmentioning

confidence: 99%

“…4 In this study, we showed that the influenza B viruses belonging to two evolutionary lineages independently caused epidemics until 1991. Herald viruses SI/64 [4], HK/73 [13], SI/79 [14], IK/85 [5], NS1/87 [5], YG16/88 [5], and AI5/88 [6] HA gene sequences were reported previously. The mark in the amino-acid column indicates a deletion.…”

Section: And Discussionmentioning

confidence: 99%

Comparison of the HA genes of type B influenza viruses in herald waves and later epidemic seasons

et al. 1992

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“…Alignments of influenza type A and B HA gene sequences (Krystal et al, 1982;Verhoeyen et al, 1983) have indicated that this region of the influenza B HA is located near the receptorbinding pocket at the distal tip of the HA molecule in an area of the molecule that is analogous to antigenic site B of the influenza type A (H3N2) HA (Wiley et al, 1981). Sequence analysis of the HAs from different strains of influenza B virus have confirmed that multiple amino acid changes are common at this site (Krystal et al, 1982;Verhoeyen et al, 1983 ;Yamashita et aL, 1988) which may represent a major antigenic region on the influenza B HA (Berton et al, 1984;Berton & Webster, 1985).…”

Section: Cross-protection Against Microvariants Of Influenza Virusmentioning

confidence: 99%

Cross-protection against Microvariants of Influenza Virus Type B by Vaccinia Viruses Expressing Haemagglutinins from Egg- or MDCK Cell-derived Subpopulations of Influenza Virus Type B/England/222/82

Rota

Shaw

Kendal

1989

Journal of General Virology

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SUMMARYB/Singapore/222/79-1ike influenza viruses isolated from three patients during the winter of 1981 to 1982 and cultured in either embryonated hens' eggs or MDCK cells were studied. Sequence analysis indicated that the haemagglutinin (HA) genes of the six virus preparations contained at least four distinct HA1 sequences which differed by up to six amino acids. Only one pair of viruses had amino acid differences between the egg-and MDCK cell-derived viral subpopulations and this change did not affect a glycosylation site. Mice infected with previously described recombinant vaccinia viruses expressing either the egg-or MDCK cell-derived HA of B/England/222/82 developed neutralizing antibodies against all of the 1982 type B viruses and were protected against intranasal challenge with these viruses. Therefore, in this model system, the minor sequence variation between the HAs of egg-and MDCK cell-derived influenza B/England/222/82 virus had no detectable effect on the induction of crossprotection.In order to compare the immune response induced by influenza virus haemagglutinins (HAs) differing by a single amino acid, we cloned the genes for a pair of such HA variants and expressed them in vaccinia virus (Rota et al., 1987). These variant HA genes were previously described as being present in either egg-derived or MDCK cell-derived subpopulations of a single isolate of influenza B/England/222/82 virus (B/Eng) (Schild et al., 1983). The single amino acid difference between the HAs was found at residue 198, which is near the receptor-binding site on the distal tip of the HA1 portion of the molecule. This change resulted in the loss of a specific N-linked glycosylation site that was present on the HA of virus from the MDCK cellderived subpopulation (Robertson et al., 1985). Our previous work has shown that mice vaccinated with the recombinant vaccinia viruses expressing either of the variant HAs were equivalently protected from infection after challenge by each of the B/Eng virus subpopulations (Rota et al

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“…The cocirculation of multiple sublineages of B/Yamagata/ 16/88-like viruses has recently been described [15]. In this study, these [15] and the root virus B/Singapore/222/79 [9].…”

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confidence: 76%

“…Antigenic drift of influenza type B virus is thought to occur in a manner similar to that of type A virus, by the accumulation of point mutations in the HAl domain of the HA gene as a result of immune pressure [7][8][9][10][11][12]. Here The antigenic characteristics of these viruses were determined using a previously described microneutralization assay with post-infection ferret serum [13].…”

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confidence: 99%

Antigenic and genetic analyses of influenza type B viruses isolated in Russia, 1987–91

et al. 1993

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SUMMARYFour influenza type B viruses isolated in Russia during periods of relatively low or high (1990-1) influenza B activity were characterized antigenically using a microneutralization assay. These isolates were antigenically similar to contemporary reference strains from either of two separate lineages represented by B/Victoria/2/87 and B/Yamagata/16/88. The evolutionary relationships of the variable portion of the haemagglutinin (HA1) genes of these viruses were determined by comparison with influenza B HAI sequences previously obtained.The Isolate B/USSR/2/87, collected during the 1987-8 influenza season, was found to be closely related to viruses on the B/Victoria/2/87 lineage that circulated during the 1988-9 influenza season in the United States. Sequence analysis of the isolates from the 1990-1 influenza season demonstrated cocirculation of viruses from both the B/Victoria/2/87 and B/Yamagata/16/88 lineages in Russia, confirming the antigenic analysis.

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Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin

Cited by 49 publications

References 37 publications

Comparison of the HA genes of type B influenza viruses in herald waves and later epidemic seasons

Comparison of the HA genes of type B influenza viruses in herald waves and later epidemic seasons

Cross-protection against Microvariants of Influenza Virus Type B by Vaccinia Viruses Expressing Haemagglutinins from Egg- or MDCK Cell-derived Subpopulations of Influenza Virus Type B/England/222/82

Antigenic and genetic analyses of influenza type B viruses isolated in Russia, 1987–91

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