Complete Heart Block in Children: Report of Three Cases Possibly Attributable to Measles

Clark, Norman S.

doi:10.1136/adc.23.115.156

Cited by 18 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cases of complete heart block following infectious hepatitis have been published (8) and myocarditis following viral infection can lead to complete heart block (9,10) . Complete heart block secondary to amoebic hepatitis and measles are also reported in the literature (11,12) but we have not found any case report of complete heart block secondary to hepatitis A in the literature.…”

Section: After Recovery It Provides a Lifelong Immunitymentioning

confidence: 64%

Complete heart block associated with hepatitis A infection in a female child with fatal outcome

Ahmed

Naseer

Rehman

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Section: After Recovery It Provides a Lifelong Immunitymentioning

confidence: 64%

Complete heart block associated with hepatitis A infection in a female child with fatal outcome

Ahmed

Naseer

Rehman

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Keratoconjunctivitis, while rare post‐vaccination and with vitamin A supplementation, can lead to blindness 62 . Severe complications in adult and pediatric SOT recipients include hepatitis leading to liver graft rejection, myocarditis, heart block, and agranulocytosis 63–67 . In addition, ongoing perturbations in naïve and memory B cells caused by the measles virus result in “immune amnesia,” rendering patients susceptible to other infections, weeks to years after their acute measles infection 68,69 …”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…62 Severe complications in adult and pediatric SOT recipients include hepatitis leading to liver graft rejection, myocarditis, heart block, and agranulocytosis. [63][64][65][66][67] In addition, ongoing perturbations in naïve and memory B cells caused by the measles virus result in "immune amnesia," rendering patients susceptible to other infections, weeks to years after their acute measles infection. 68,69 Death from measles results from respiratory or neurologic complications in 1-3 of every 1000 cases.…”

Section: Clinic Al Manife S Tationsmentioning

confidence: 99%

Spotting a potential threat: Measles among pediatric solid organ transplantation recipients

Statler

Fox

Ardura

2023

Pediatric Transplantation

View full text Add to dashboard Cite

Background Low‐vaccination rates worldwide have led to the re‐emergence of vaccine‐preventable infections, including measles. Immunocompromised patients, including pediatric solid organ transplant (SOT) recipients, are at risk for measles because of suboptimal vaccination, reduced or waning vaccine immunity, lifelong immunosuppression, and global re‐emergence of measles. Objectives To review published cases of measles in pediatric SOT recipients to heighten awareness of its clinical manifestations, summarize diagnostic and treatment strategies, and identify opportunities to optimize prevention. Methods We conducted a literature review of published natural measles infections in SOT recipients ≤21 years of age, summarizing management and outcomes. We describe measles epidemiology, recommended diagnostics, treatment, and highlight prevention strategies. Results There are seven published reports of measles infection in 12 pediatric SOT recipients, the majority of whom were unvaccinated or incompletely vaccinated. Subjects had atypical or severe clinical presentations, including lack of rash and complications, most frequently with encephalitis and pneumonitis, resulting in 33% mortality. Updated recommendations on testing and vaccination are provided. Treatment options beyond supportive care and vitamin A are limited, with no approved antivirals. Conclusion While measles is infrequently reported in pediatric SOT recipients, morbidity and mortality remain significant. A high index of suspicion is warranted in susceptible SOT recipients with clinically compatible illness or exposure. Providers must recognize this risk, educate families, and be aware of both classic and atypical presentations of measles to rapidly identify, isolate, and diagnose measles in pediatric SOT recipients. Continued efforts to optimize measles vaccination both pre‐ and post‐SOT are warranted.

show abstract

Myocarditis Following Measles

Giustra¹,

Nilsson²

1950

Am J Dis Child

View full text Add to dashboard Cite

Complete Heart Block in Children: Report of Three Cases Possibly Attributable to Measles

Cited by 18 publications

References 8 publications

Complete heart block associated with hepatitis A infection in a female child with fatal outcome

Complete heart block associated with hepatitis A infection in a female child with fatal outcome

Spotting a potential threat: Measles among pediatric solid organ transplantation recipients

Myocarditis Following Measles

Contact Info

Product

Resources

About