Complete Heart Block in a Patient with Wegener's Granulomatosis in Remission

Suleymenlar, Gultekin; Sarıkaya, Metin; Sarı, Ramazan; Tuncer, Murat; Sevinç, Alper

doi:10.1177/000331970205300312

Cited by 24 publications

(14 citation statements)

References 12 publications

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“…Forstot et al [7]reported conduction system granulomata in 17% of WG patients, and arteritis of the blood supply to the atrioventricular node in 11% of cases. Several cases of high-grade atrioventricular block, including complete heart block, have been reported in the literature [4, 7, 11, 40, 41, 42, 43, 44]. Notably, the block may be reversible and responsive to intensification of the pharmacological therapy for WG.…”

Section: Conduction Disorders and Arrhythmiasmentioning

confidence: 99%

The Heart in Wegener’s Granulomatosis

2004

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Wegener’s granulomatosis (WG) is a necrotizing vasculitis that mainly affects the respiratory tract and kidneys. Of note, involvement of the heart is being increasingly recognized in these patients. Cardiac manifestations can arise from the coronary arteries, pericardium, myocardium, endocardium, valves, conduction system and great vessels, but in most cases cardiac involvement is clinically silent. Consequently, a regular cardiovascular evaluation, including echocardiography, should be performed in every patient with WG, while patients with WG flare should be closely monitored for cardiac complications even in the absence of specific symptoms.

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Section: Conduction Disorders and Arrhythmiasmentioning

confidence: 99%

The Heart in Wegener’s Granulomatosis

2004

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“…Since then, there have only been 13 cases previously reported in the published literature and all but one case was associated with systemic disease (Table 1) [1,[3][4][5][6][7][8][9][10][11][12][13][14]. Complete AV block was present at disease onset in 50% and in 70% by one year.…”

Section: Discussionmentioning

confidence: 99%

A patient with Wegener's granulomatosis in apparent remission presenting with complete atrioventricular block

Cassidy

Sowden

Brockbank

et al. 2011

Journal of Cardiology Cases

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Wegener's granulomatosis is a systemic necrotizing granulomatous vasculitis of small-to medium-sized vessels typically affecting upper and lower airways, lungs, and kidneys. Cardiac involvement is less common and conducting tissue involvement is extremely rare. Cardiac manifestations are often not clinically apparent, but are associated with increased mortality. We report the case of a 36-year-old female with Wegener's thought to be in remission, presenting in complete atrioventricular (AV) block, with echocardiographic evidence of basal interatrial septum and basal lateral left atrial wall thickening. Despite immunosuppression therapy a permanent pacemaker was required for recurring complete AV block. Although rare, this case emphasizes the need for careful and regular screening for cardiac involvement in this multi-system condition.

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“…Necrotising angiitis and severe granulomatous inflammatory foci affected the common bundle of His and right bundle branch in addition to the myocardium [32]. Suleymenlar et al [33] report a case of patients with completed heart block due to GPA. Inflammation near the atrioventricular (AV) node was seen on computerised tomography (CT) and cardiac MRI, but also was confirmed by a myocardial perfusion scan with gallium [33].…”

Section: Cardiac Manifestation In Granulomatosis With Polyangiitismentioning

confidence: 99%

“…Suleymenlar et al [33] report a case of patients with completed heart block due to GPA. Inflammation near the atrioventricular (AV) node was seen on computerised tomography (CT) and cardiac MRI, but also was confirmed by a myocardial perfusion scan with gallium [33].…”

Section: Cardiac Manifestation In Granulomatosis With Polyangiitismentioning

confidence: 99%