Complete Healing of a Laboratory-Confirmed Buruli Ulcer Lesion after Receiving Only Herbal Household Remedies

Andreoli, Arianna; Mou, Ferdinand; Minyem, Jacques C.; Wantong, Fidèle G.; Noumen, Djeunga; Awah, Paschal Kum; Pluschke, Gerd; Boock, Alphonse Um; Bratschi, Martin W.

doi:10.1371/journal.pntd.0004102

Cited by 5 publications

(9 citation statements)

References 16 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Herbal medicinal products have been utilized as treatment options for BU in many African countries [ 89 ]. A previous study by [ 92 ] reported that, the administration of an herbal formulation comprising of Erythropheleum suaveolens and Stemonocoleus micrantus completely healed BU wounds. A great reservoir of herbal medicinal resources for treating BU has also been discovered by an ethnobotanical survey in the West Africa, particularly in Ivory Coast, Ghana, and Benin [ 22 ].…”

Section: Health Systems In Africa and Implications For Bu Managementmentioning

confidence: 99%

See 1 more Smart Citation

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Osei-Owusu,

Aidoo,

Eshun

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Health Systems In Africa and Implications For Bu Managementmentioning

confidence: 99%

“…& Perr. ], Brenan), and Stemonocoleus micranthus (Harms) were used to completely heal a patient with BU ( Table 4 , [ 91 ].…”

Section: Health Systems In Africa and Implications For Bu Managementmentioning

confidence: 99%

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Osei-Owusu,

Aidoo,

Eshun

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Due to side effects and one targetspecific action of allopathic drugs, medicinal herbs or plant natural products work in a way that depends on an orchestral approach. ere are multitudes of different molecules in a plant that work coactively on targeted components of the complex cellular pathway [5,7]. For many centuries, a wide variety of biologically active compounds have been sourced from medicinal plants and utilized magnificently either as pure compounds or as crude material for treating various human and animal disease conditions [6].…”

Section: Introductionmentioning

confidence: 99%

“…e stem bark decoction of this plant is most widely used traditionally as remedies for various diseases [9]. Although this plant has not been well investigated, there are reports on its analgesic, narrow-spectrum antibacterial, central nervous system (CNS) depressant, local anesthetic [10], antiulcer [11], antioxidant and hepatoprotective [12], hypolipidemic [13], antimicrobial [14], and antimalarial [15] activities including its use for the treatment of Buruli ulcer lesion in Cameroon [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Methanol‐Dichloromethane Extract of Stemonocoleus micranthus Harms (Fabaceae) Stem Bark for Anti‐Inflammatory and Immunomodulatory Activities

Mbaoji

Onwuka

Onu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. The stem bark decoction of Stemonocoleus micranthus Harms (Fabaceae) is most widely used traditionally as a remedy for various diseases such as malaria and boil. In this study, the anti-inflammatory and immunomodulatory activities of the methanol-dichloromethane extract (MDE) from the stem bark of the plant in rodents were evaluated. Methods. The carrageenan-induced rat paw oedema, cotton pellet-induced granuloma in rat, and xylene-induced ear oedema in mice were used to study the anti-inflammatory activity of methanol-dichloromethane extract of Stemonocoleus micranthus (MDESm) (100, 200, and 400 mg/kg). The effects of MDESm (100, 200, and 400 mg/kg) on cyclophosphamide-induced immunosuppression, neutrophil adhesion, carbon clearance, and haematological and biochemical parameters were carried out to study its immunomodulatory activity in mice. Result. MDESm (100 mg/kg, p.o.) significantly (p<0.05) inhibited carrageenan-induced oedema by 57.1% at 5th h posttreatment compared with control. At 100 mg/kg, p.o., MDESm significantly (p<0.05) reduced cotton pellet-induced granuloma by 39.28% and nonsignificantly reduced xylene-induced ear oedema by 34.1%. Treatment with MDESm (100 and 400 mg/kg) nonsignificantly abolished the neutropenia caused by cyclophosphamide with a percentage neutrophil reduction of 0 and −14.86%, respectively, while MDESm (200 mg/kg) and levamisole (50 mg/kg) had a nonsignificant reduction in neutrophil count (10.16 and 31.40%), respectively, all compared to the distilled water-treated group with a neutrophil count of −9.82%. MDESm at doses of 100 and 200 mg/kg increased phagocytic index by 0.0447 ± 0.00762 and 0.0466 ± 0.00703, respectively, although not significantly when compared to the control group with a value of 0.0226 ± 0.02117. There was a decrease in WBC and lymphocyte counts in MDESm- (200 mg/kg) treated group, suggesting immunosuppressive potential at this dose. MDESm caused a dose-dependent decrease in ALT and core liver enzymes, suggesting a hepatoprotective effect. The acute toxicity test revealed that MDESm is safe in mice with an oral lethal dose (LD50) of >5 g/kg. Conclusion. The methanol-dichloromethane extract of Stemonocoleus micranthus Harms possesses mild anti-inflammatory and immunomodulatory activities which may be more pronounced upon fractionation and purification. Therefore, more investigations are needed to explore these activities further.

show abstract

“…Ses foyers sont géographiquement presque toujours circonscrits autour d'un écosystème aquatique, notamment les fleuves, lacs artificiels ou naturels, zones marécageuses, systèmes d'irrigation (Yemoa et al, 2008;Aubry et Gaüzère, 2015). D'après Aubry et Gaüzère (2015), environ 5000 nouveaux cas sont répertoriés chaque année, mais beaucoup de cas ne sont pas diagnostiqués, car la maladie reste mal connue et les personnes touchées proviennent principalement des communautés pauvres et (Pouillot et al, 2007;Bratschi et al, 2013;Andreoli et al, 2015). Cette infection, n'entraînant que peu de décès, est cependant à l'origine d'importantes incapacités fonctionnelles car, elle conduit souvent à une destruction étendue de la peau et des tissus mous, avec formation d'ulcérations importantes généralement sur les membres.…”

Section: Introductionunclassified

Approche ethnobotanique et ethnopharmacologique des plantes utilisées dans le traitement traditionnel de l’ulcère de Buruli à Akonolinga (Cameroun)

Herve¹,

Guedje²,

Biye³

2017

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

Ethnopharmacological and ethnobotanical approach of medicinal plants used in the traditional treatment of Buruli ulcer in Akonolinga (Cameroon) ABSTRACTFew data are available concerning plants used in the traditional treatment of Buruli ulcer in Cameroon. This study aimed to identify species and characterize anti-Buruli ulcer recipes in the Akonolinga district. The H. N. BAYAGA et al. / Int. J. Biol. Chem. Sci. 11(4): 1523-1541, 2017 1524 ethnopharmacological survey has enabled to identify 25 plant species used against Buruli ulcer. The plant parts mostly used were stem bark (41.1%), stem (26.8%) and leaves (25%). Decoction (64.3%) and pounding (23.2%), the most dominant preparing method, were administrated externally, mostly by massage and disinfection (64.3%) and by local poultice application (14.3%). The analysis of relative frequency of citation, as well as the search of similarity and convergence of use, have shown that Musa parasidiaca, Mitracarpus villosus, Aframomum melegueta, Elaeis guineensis and Spathodea campanulata were among species exhibiting remarkable convergence of use between different geographical regions; while seven others, Petersianthus macrocarpus, Momordica cabraei, Cassia spectabilis, Citrus medica, Terminalia superba, Ceiba pentandra and Ipomoea aquatica, formed another most significant species group. In highlighting those 12 species of interest, this study has direct bearing in drug design and innovation by the ethnopharmacological reasoning, thereby contributing to species selection and direction for prior chemical, pharmacological and clinical assessments leading to plant-based drug development that Africa needed for its pandemic pathologies.

show abstract

Complete Healing of a Laboratory-Confirmed Buruli Ulcer Lesion after Receiving Only Herbal Household Remedies

Cited by 5 publications

References 16 publications

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Evaluation of Methanol‐Dichloromethane Extract of Stemonocoleus micranthus Harms (Fabaceae) Stem Bark for Anti‐Inflammatory and Immunomodulatory Activities

Approche ethnobotanique et ethnopharmacologique des plantes utilisées dans le traitement traditionnel de l’ulcère de Buruli à Akonolinga (Cameroun)

Contact Info

Product

Resources

About